The feasibility study of the transmission mode photoacoustic measurement of human calcaneus bone in vivo
The photoacoustic (PA) technique is uniquely positioned for biomedical applications primarily due to its ability to visualize optical absorption contrast in deep tissue at ultrasound resolution. In this work, via both three-dimensional (3D) numerical simulations and in vivo experiments on human subj...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Photoacoustics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597921000343 |
| _version_ | 1824021328640868352 |
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| author | Ting Feng Yunhao Zhu Richard Morris Kenneth M. kozloff Xueding Wang |
| author_facet | Ting Feng Yunhao Zhu Richard Morris Kenneth M. kozloff Xueding Wang |
| author_sort | Ting Feng |
| collection | DOAJ |
| description | The photoacoustic (PA) technique is uniquely positioned for biomedical applications primarily due to its ability to visualize optical absorption contrast in deep tissue at ultrasound resolution. In this work, via both three-dimensional (3D) numerical simulations and in vivo experiments on human subjects, we investigated the possibility of PA measurement of human calcaneus bones in vivo in a non-invasive manner, as well as its feasibility to differentiate osteoporosis patients from normal subjects. The results from the simulations and the experiments both demonstrated that, when one side of the heel is illuminated by laser with light fluence under the ANSI safety limit, the PA signal generated in the human calcaneus bone can be detected by an ultrasonic transducer at the other side of the heel (i.e. transmission mode). Quantitative power spectral analyses of the calcaneus bone PA signals were also conducted, demonstrating that the microarchitectural changes in calcaneus bone due to osteoporosis can be detected, as reflected by enhanced high frequency components in detected PA bone signal. Further statistical analysis of the experimental results from 10 osteoporosis patients and 10 healthy volunteers showed that the weighted frequency as a quantified PA spectral parameter can differentiate the two subject groups with statistical significance. |
| first_indexed | 2024-12-19T01:44:10Z |
| format | Article |
| id | doaj.art-4245b4af4bf3418ca732620c844ac69f |
| institution | Directory Open Access Journal |
| issn | 2213-5979 |
| language | English |
| last_indexed | 2024-12-19T01:44:10Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj.art-4245b4af4bf3418ca732620c844ac69f2022-12-21T20:41:41ZengElsevierPhotoacoustics2213-59792021-09-0123100273The feasibility study of the transmission mode photoacoustic measurement of human calcaneus bone in vivoTing Feng0Yunhao Zhu1Richard Morris2Kenneth M. kozloff3Xueding Wang4Department of Biomedical Engineering, University of Michigan Medical School, MI 48109, USADepartment of Biomedical Engineering, University of Michigan Medical School, MI 48109, USAIF, LLC, WI 53589, USADepartment of Biomedical Engineering, University of Michigan Medical School, MI 48109, USA; Department of Orthopaedic Surgery, University of Michigan Medical School, MI 48109, USA; Corresponding authors at: Department of Biomedical Engineering, University of Michigan Medical School, MI 48109, USA.Department of Biomedical Engineering, University of Michigan Medical School, MI 48109, USA; Department of Radiology, University of Michigan Medical School, MI 48109, USA; Corresponding authors at: Department of Biomedical Engineering, University of Michigan Medical School, MI 48109, USA.The photoacoustic (PA) technique is uniquely positioned for biomedical applications primarily due to its ability to visualize optical absorption contrast in deep tissue at ultrasound resolution. In this work, via both three-dimensional (3D) numerical simulations and in vivo experiments on human subjects, we investigated the possibility of PA measurement of human calcaneus bones in vivo in a non-invasive manner, as well as its feasibility to differentiate osteoporosis patients from normal subjects. The results from the simulations and the experiments both demonstrated that, when one side of the heel is illuminated by laser with light fluence under the ANSI safety limit, the PA signal generated in the human calcaneus bone can be detected by an ultrasonic transducer at the other side of the heel (i.e. transmission mode). Quantitative power spectral analyses of the calcaneus bone PA signals were also conducted, demonstrating that the microarchitectural changes in calcaneus bone due to osteoporosis can be detected, as reflected by enhanced high frequency components in detected PA bone signal. Further statistical analysis of the experimental results from 10 osteoporosis patients and 10 healthy volunteers showed that the weighted frequency as a quantified PA spectral parameter can differentiate the two subject groups with statistical significance.http://www.sciencedirect.com/science/article/pii/S2213597921000343Photoacoustic measurementTissue characterizationBone microarchitectureOsteoporosisThree-dimensional simulation |
| spellingShingle | Ting Feng Yunhao Zhu Richard Morris Kenneth M. kozloff Xueding Wang The feasibility study of the transmission mode photoacoustic measurement of human calcaneus bone in vivo Photoacoustics Photoacoustic measurement Tissue characterization Bone microarchitecture Osteoporosis Three-dimensional simulation |
| title | The feasibility study of the transmission mode photoacoustic measurement of human calcaneus bone in vivo |
| title_full | The feasibility study of the transmission mode photoacoustic measurement of human calcaneus bone in vivo |
| title_fullStr | The feasibility study of the transmission mode photoacoustic measurement of human calcaneus bone in vivo |
| title_full_unstemmed | The feasibility study of the transmission mode photoacoustic measurement of human calcaneus bone in vivo |
| title_short | The feasibility study of the transmission mode photoacoustic measurement of human calcaneus bone in vivo |
| title_sort | feasibility study of the transmission mode photoacoustic measurement of human calcaneus bone in vivo |
| topic | Photoacoustic measurement Tissue characterization Bone microarchitecture Osteoporosis Three-dimensional simulation |
| url | http://www.sciencedirect.com/science/article/pii/S2213597921000343 |
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