Cell-type differential targeting of SETDB1 prevents aberrant CTCF binding, chromatin looping, and cis-regulatory interactions

Cell-type differential targeting of SETDB1 prevents aberrant CTCF binding, chromatin looping, and cis-regulatory interactions

Abstract SETDB1 is an essential histone methyltransferase that deposits histone H3 lysine 9 trimethylation (H3K9me3) to transcriptionally repress genes and repetitive elements. The function of differential H3K9me3 enrichment between cell-types remains unclear. Here, we demonstrate mutual exclusivity...

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Bibliographic Details
Main Authors:	Phoebe Lut Fei Tam, Ming Fung Cheung, Lu Yan Chan, Danny Leung
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-023-44578-0

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