Effects of Different Types of Carbohydrates on Arterial Stiffness: A Comparison of Isomaltulose and Sucrose
Increased arterial stiffness during acute hyperglycemia is a risk factor for cardiovascular disease, but the type of carbohydrate that inhibits it is unknown. The purpose of this study was to determine the efficacy of low-glycemic-index isomaltulose on arterial stiffness during hyperglycemia in midd...
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MDPI AG
2021-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/12/4493 |
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| author | Ryota Kobayashi Miki Sakazaki Yukie Nagai Kenji Asaki Takeo Hashiguchi Hideyuki Negoro |
| author_facet | Ryota Kobayashi Miki Sakazaki Yukie Nagai Kenji Asaki Takeo Hashiguchi Hideyuki Negoro |
| author_sort | Ryota Kobayashi |
| collection | DOAJ |
| description | Increased arterial stiffness during acute hyperglycemia is a risk factor for cardiovascular disease, but the type of carbohydrate that inhibits it is unknown. The purpose of this study was to determine the efficacy of low-glycemic-index isomaltulose on arterial stiffness during hyperglycemia in middle-aged and older adults. Ten healthy middle-aged and older adult subjects orally ingested a solution containing 25 g of isomaltulose (ISI trial) and sucrose (SSI trial) in a crossover study. In the SSI trial, the brachial–ankle (ba) pulse wave velocity (PWV) increased 30, 60, and 90 min after ingestion compared with that before ingestion (<i>p</i> < 0.01); however, in the ISI trial, the baPWV did not change after ingestion compared with that before ingestion. Blood glucose levels 30 min after intake were lower in the ISI trial than in the SSI trial (<i>p</i> < 0.01). The baPWV and systolic blood pressure were positively correlated 90 min after isomaltulose and sucrose ingestion (<i>r</i> = 0.640, <i>p</i> < 0.05). These results indicate that isomaltulose intake inhibits an acute increase in arterial stiffness. The results of the present study may have significant clinical implications on the implementation of dietary programs for middle-aged and elderly patients. |
| first_indexed | 2024-03-10T03:23:16Z |
| format | Article |
| id | doaj.art-4248bcf50fc24fe1941ef5448e741d7e |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T03:23:16Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
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| series | Nutrients |
| spelling | doaj.art-4248bcf50fc24fe1941ef5448e741d7e2023-11-23T09:58:29ZengMDPI AGNutrients2072-66432021-12-011312449310.3390/nu13124493Effects of Different Types of Carbohydrates on Arterial Stiffness: A Comparison of Isomaltulose and SucroseRyota Kobayashi0Miki Sakazaki1Yukie Nagai2Kenji Asaki3Takeo Hashiguchi4Hideyuki Negoro5Center for Fundamental Education, Teikyo University of Science, Tokyo 120-0045, JapanResearch & Development Division, Mitsui Sugar Co., Ltd., Tokyo 103-8423, JapanResearch & Development Division, Mitsui Sugar Co., Ltd., Tokyo 103-8423, JapanDepartment of Tokyo Judo Therapy, Teikyo University of Science, Tokyo 120-0045, JapanDepartment of School Education, Teikyo University of Science, Tokyo 120-0045, JapanHarvard PKD Center for Polycystic Kidney Disease Research, Boston, MA 02115, USAIncreased arterial stiffness during acute hyperglycemia is a risk factor for cardiovascular disease, but the type of carbohydrate that inhibits it is unknown. The purpose of this study was to determine the efficacy of low-glycemic-index isomaltulose on arterial stiffness during hyperglycemia in middle-aged and older adults. Ten healthy middle-aged and older adult subjects orally ingested a solution containing 25 g of isomaltulose (ISI trial) and sucrose (SSI trial) in a crossover study. In the SSI trial, the brachial–ankle (ba) pulse wave velocity (PWV) increased 30, 60, and 90 min after ingestion compared with that before ingestion (<i>p</i> < 0.01); however, in the ISI trial, the baPWV did not change after ingestion compared with that before ingestion. Blood glucose levels 30 min after intake were lower in the ISI trial than in the SSI trial (<i>p</i> < 0.01). The baPWV and systolic blood pressure were positively correlated 90 min after isomaltulose and sucrose ingestion (<i>r</i> = 0.640, <i>p</i> < 0.05). These results indicate that isomaltulose intake inhibits an acute increase in arterial stiffness. The results of the present study may have significant clinical implications on the implementation of dietary programs for middle-aged and elderly patients.https://www.mdpi.com/2072-6643/13/12/4493arterial stiffnessglucose ingestionmiddle-aged and older patientsisomaltulosesucrose |
| spellingShingle | Ryota Kobayashi Miki Sakazaki Yukie Nagai Kenji Asaki Takeo Hashiguchi Hideyuki Negoro Effects of Different Types of Carbohydrates on Arterial Stiffness: A Comparison of Isomaltulose and Sucrose Nutrients arterial stiffness glucose ingestion middle-aged and older patients isomaltulose sucrose |
| title | Effects of Different Types of Carbohydrates on Arterial Stiffness: A Comparison of Isomaltulose and Sucrose |
| title_full | Effects of Different Types of Carbohydrates on Arterial Stiffness: A Comparison of Isomaltulose and Sucrose |
| title_fullStr | Effects of Different Types of Carbohydrates on Arterial Stiffness: A Comparison of Isomaltulose and Sucrose |
| title_full_unstemmed | Effects of Different Types of Carbohydrates on Arterial Stiffness: A Comparison of Isomaltulose and Sucrose |
| title_short | Effects of Different Types of Carbohydrates on Arterial Stiffness: A Comparison of Isomaltulose and Sucrose |
| title_sort | effects of different types of carbohydrates on arterial stiffness a comparison of isomaltulose and sucrose |
| topic | arterial stiffness glucose ingestion middle-aged and older patients isomaltulose sucrose |
| url | https://www.mdpi.com/2072-6643/13/12/4493 |
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