Outcome of drug-resistant tuberculosis treatment among HIV-positive patients at the tertiary center in Tehran
Objectives: Drug-resistant tuberculosis (TB) is a major challenge in controlling TB. HIV-positive patients are vulnerable to TB 100 times more than the general population. Drug-resistant TB leads to high morbidity and mortality in this population. In this study, the outcome of treatment of drug-resi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | International Journal of Mycobacteriology |
| Subjects: | |
| Online Access: | http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=5;spage=115;epage=115;aulast=Tabarsi;type=0 |
| _version_ | 1818147123236962304 |
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| author | Payam Tabarsi Parvaneh Baghaei Afshin Moniri Majid Marjani Ali Akbar Velayati |
| author_facet | Payam Tabarsi Parvaneh Baghaei Afshin Moniri Majid Marjani Ali Akbar Velayati |
| author_sort | Payam Tabarsi |
| collection | DOAJ |
| description | Objectives: Drug-resistant tuberculosis (TB) is a major challenge in controlling TB. HIV-positive patients are vulnerable to TB 100 times more than the general population. Drug-resistant TB leads to high morbidity and mortality in this population. In this study, the outcome of treatment of drug-resistant TB among HIV positive patients from 2003 to 2013 in a tertiary center in Iran will be reviewed.
Materials and Methods: All HIV-positive patients with any drug-resistant TB from 2003 to 2013 were selected. The outcome of treatment was extracted from patients’ charts.
Results: Out of 269 TB-HIV patients, 34 patients were recruited. All patients were male and the mean age was 37.38±7.03. Isoniazid (INH) resistant, rifampin (RIF) resistant and multi-drug resistant (MDR) was diagnosed in 11 (32.4%), 7 (20.6%) and 16 (47.1%), respectively. Mean CD4 count was 91.61±23.55. Outcome of treatment in the INH-resistant cases was cured in 5 (45.5%), failure in 2 (18.2%) and death in 4 (36.4%). In the RIF-resistant group, outcome was as follows: cured 5 (71.4%) and failure in 2 (28.6%). In the MDR-TB patients’ group, cured, failure and death were 12 (75%), 2 (12.5%) and 2 (12.5%), respectively.
Conclusion: Treatment of drug-resistant TB can be achieved despite considerable mortality. |
| first_indexed | 2024-12-11T12:30:14Z |
| format | Article |
| id | doaj.art-424ac8f7eb5042dfa0f239b14cc60f3a |
| institution | Directory Open Access Journal |
| issn | 2212-5531 2212-554X |
| language | English |
| last_indexed | 2024-12-11T12:30:14Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | International Journal of Mycobacteriology |
| spelling | doaj.art-424ac8f7eb5042dfa0f239b14cc60f3a2022-12-22T01:07:16ZengWolters Kluwer Medknow PublicationsInternational Journal of Mycobacteriology2212-55312212-554X2015-01-0145115115Outcome of drug-resistant tuberculosis treatment among HIV-positive patients at the tertiary center in TehranPayam TabarsiParvaneh BaghaeiAfshin MoniriMajid MarjaniAli Akbar VelayatiObjectives: Drug-resistant tuberculosis (TB) is a major challenge in controlling TB. HIV-positive patients are vulnerable to TB 100 times more than the general population. Drug-resistant TB leads to high morbidity and mortality in this population. In this study, the outcome of treatment of drug-resistant TB among HIV positive patients from 2003 to 2013 in a tertiary center in Iran will be reviewed. Materials and Methods: All HIV-positive patients with any drug-resistant TB from 2003 to 2013 were selected. The outcome of treatment was extracted from patients’ charts. Results: Out of 269 TB-HIV patients, 34 patients were recruited. All patients were male and the mean age was 37.38±7.03. Isoniazid (INH) resistant, rifampin (RIF) resistant and multi-drug resistant (MDR) was diagnosed in 11 (32.4%), 7 (20.6%) and 16 (47.1%), respectively. Mean CD4 count was 91.61±23.55. Outcome of treatment in the INH-resistant cases was cured in 5 (45.5%), failure in 2 (18.2%) and death in 4 (36.4%). In the RIF-resistant group, outcome was as follows: cured 5 (71.4%) and failure in 2 (28.6%). In the MDR-TB patients’ group, cured, failure and death were 12 (75%), 2 (12.5%) and 2 (12.5%), respectively. Conclusion: Treatment of drug-resistant TB can be achieved despite considerable mortality.http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=5;spage=115;epage=115;aulast=Tabarsi;type=0Resistance tuberculosisHIVTreatment outcomeINHRIF |
| spellingShingle | Payam Tabarsi Parvaneh Baghaei Afshin Moniri Majid Marjani Ali Akbar Velayati Outcome of drug-resistant tuberculosis treatment among HIV-positive patients at the tertiary center in Tehran International Journal of Mycobacteriology Resistance tuberculosis HIV Treatment outcome INH RIF |
| title | Outcome of drug-resistant tuberculosis treatment among HIV-positive patients at the tertiary center in Tehran |
| title_full | Outcome of drug-resistant tuberculosis treatment among HIV-positive patients at the tertiary center in Tehran |
| title_fullStr | Outcome of drug-resistant tuberculosis treatment among HIV-positive patients at the tertiary center in Tehran |
| title_full_unstemmed | Outcome of drug-resistant tuberculosis treatment among HIV-positive patients at the tertiary center in Tehran |
| title_short | Outcome of drug-resistant tuberculosis treatment among HIV-positive patients at the tertiary center in Tehran |
| title_sort | outcome of drug resistant tuberculosis treatment among hiv positive patients at the tertiary center in tehran |
| topic | Resistance tuberculosis HIV Treatment outcome INH RIF |
| url | http://www.ijmyco.org/article.asp?issn=2212-5531;year=2015;volume=4;issue=5;spage=115;epage=115;aulast=Tabarsi;type=0 |
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