Development of vaccines against the sexually transmitted infections gonorrhoea, syphilis, Chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus
The success in preventing hepatitis B virus and human papillomavirus infections by means of vaccination paves the way for the development of other vaccines to prevent sexually transmitted infections (STIs) such as gonorrhoea, syphilis, chlamydia, herpes simplex virus, human immunodeficiency virus an...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-06-01
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| Series: | Therapeutic Advances in Vaccines and Immunotherapy |
| Online Access: | https://doi.org/10.1177/2515135520923887 |
| _version_ | 1818239432467152896 |
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| author | Edwin David G. McIntosh |
| author_facet | Edwin David G. McIntosh |
| author_sort | Edwin David G. McIntosh |
| collection | DOAJ |
| description | The success in preventing hepatitis B virus and human papillomavirus infections by means of vaccination paves the way for the development of other vaccines to prevent sexually transmitted infections (STIs) such as gonorrhoea, syphilis, chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus. The current status of vaccine development for these infections will be explored in this review. The general principles for success include the need for prevention of latency, persistence and repeat infections. A reduction in transmission of STIs would reduce the global burden of disease. Therapeutic activity of vaccines against STIs would be advantageous over preventative activity alone, and prevention of congenital and neonatal infections would be an added benefit. There would be an added value in the prevention of long-term consequences of STIs. It may be possible to re-purpose ‘old’ vaccines for new indications. One of the major challenges is the determination of the target populations for STI vaccination. |
| first_indexed | 2024-12-12T12:57:27Z |
| format | Article |
| id | doaj.art-424bbaf70e114196980e7a59ea5135c2 |
| institution | Directory Open Access Journal |
| issn | 2515-1363 |
| language | English |
| last_indexed | 2024-12-12T12:57:27Z |
| publishDate | 2020-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Vaccines and Immunotherapy |
| spelling | doaj.art-424bbaf70e114196980e7a59ea5135c22022-12-22T00:23:51ZengSAGE PublishingTherapeutic Advances in Vaccines and Immunotherapy2515-13632020-06-01810.1177/2515135520923887Development of vaccines against the sexually transmitted infections gonorrhoea, syphilis, Chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virusEdwin David G. McIntoshThe success in preventing hepatitis B virus and human papillomavirus infections by means of vaccination paves the way for the development of other vaccines to prevent sexually transmitted infections (STIs) such as gonorrhoea, syphilis, chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus. The current status of vaccine development for these infections will be explored in this review. The general principles for success include the need for prevention of latency, persistence and repeat infections. A reduction in transmission of STIs would reduce the global burden of disease. Therapeutic activity of vaccines against STIs would be advantageous over preventative activity alone, and prevention of congenital and neonatal infections would be an added benefit. There would be an added value in the prevention of long-term consequences of STIs. It may be possible to re-purpose ‘old’ vaccines for new indications. One of the major challenges is the determination of the target populations for STI vaccination.https://doi.org/10.1177/2515135520923887 |
| spellingShingle | Edwin David G. McIntosh Development of vaccines against the sexually transmitted infections gonorrhoea, syphilis, Chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus Therapeutic Advances in Vaccines and Immunotherapy |
| title | Development of vaccines against the sexually transmitted infections gonorrhoea, syphilis, Chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus |
| title_full | Development of vaccines against the sexually transmitted infections gonorrhoea, syphilis, Chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus |
| title_fullStr | Development of vaccines against the sexually transmitted infections gonorrhoea, syphilis, Chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus |
| title_full_unstemmed | Development of vaccines against the sexually transmitted infections gonorrhoea, syphilis, Chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus |
| title_short | Development of vaccines against the sexually transmitted infections gonorrhoea, syphilis, Chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus |
| title_sort | development of vaccines against the sexually transmitted infections gonorrhoea syphilis chlamydia herpes simplex virus human immunodeficiency virus and zika virus |
| url | https://doi.org/10.1177/2515135520923887 |
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