Exploiting Differences in Heme Biosynthesis between Bacterial Species to Screen for Novel Antimicrobials

Exploiting Differences in Heme Biosynthesis between Bacterial Species to Screen for Novel Antimicrobials

The final three steps of heme biogenesis exhibit notable differences between di- and mono-derm bacteria. The former employs the protoporphyrin-dependent (PPD) pathway, while the latter utilizes the more recently uncovered coproporphyrin-dependent (CPD) pathway. In order to devise a rapid screen for...

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Bibliographic Details
Main Authors: Laurie K. Jackson, Tammy A. Dailey, Brenden Anderle, Martin J. Warren, Hector A. Bergonia, Harry A. Dailey, John D. Phillips
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Biomolecules
Subjects:
antimicrobial
heme biosynthesis
screen
monoderm
diderm
Online Access:https://www.mdpi.com/2218-273X/13/10/1485

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