On the need of objective vigilance monitoring: Effects of sleep loss on target detection and task-negative activity using combined EEG/fMRI
Sleep loss affects attention by reducing levels of arousal and alertness. The neural mechanisms underlying the compensatory efforts of the brain to maintain attention and performance after sleep deprivation are not fully understood. Previous neuroimaging studies of sleep deprivation have not been ab...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2012.00067/full |
| _version_ | 1818021947185823744 |
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| author | Michael eCzisch Renate eWehrle Helga A Harsay Helga A Harsay Thomas Christian Wetter Thomas Christian Wetter Florian eHolsboer Philipp Georg Sämann Sean P.A. Drummond Sean P.A. Drummond |
| author_facet | Michael eCzisch Renate eWehrle Helga A Harsay Helga A Harsay Thomas Christian Wetter Thomas Christian Wetter Florian eHolsboer Philipp Georg Sämann Sean P.A. Drummond Sean P.A. Drummond |
| author_sort | Michael eCzisch |
| collection | DOAJ |
| description | Sleep loss affects attention by reducing levels of arousal and alertness. The neural mechanisms underlying the compensatory efforts of the brain to maintain attention and performance after sleep deprivation are not fully understood. Previous neuroimaging studies of sleep deprivation have not been able to exclude the effects of reduced arousal and vigilance when examining cerebral responses to cognitive challenges. Here, we used a simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) approach to study the effects of 36 hours of total sleep deprivation (TSD). Specifically, we focused on changes in selective attention processes as induced by an active acoustic oddball task, with the ability to isolate runs with objective EEG signs of high or reduced vigilance. At high vigilance, task-related activity appears to be sustained by compensatory co-activation of insular regions, but task-negative activity in the right posterior node of the default mode network is altered following TSD. When EEG shows signs of reduced vigilance, task-positive activity was massively impaired, but task-negative activation was showing levels comparable with the control condition after a well-rested night. Our results suggest that loss of strict anti-correlation between task-positive and task-negative activation reflects the effects of TSD, while the actual state of vigilance and task performance either affects task-related or task-negative activity. |
| first_indexed | 2024-04-14T08:25:05Z |
| format | Article |
| id | doaj.art-424c6c10b6a84be984cac08386fabae2 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-14T08:25:05Z |
| publishDate | 2012-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-424c6c10b6a84be984cac08386fabae22022-12-22T02:04:05ZengFrontiers Media S.A.Frontiers in Neurology1664-22952012-04-01310.3389/fneur.2012.0006721955On the need of objective vigilance monitoring: Effects of sleep loss on target detection and task-negative activity using combined EEG/fMRIMichael eCzisch0Renate eWehrle1Helga A Harsay2Helga A Harsay3Thomas Christian Wetter4Thomas Christian Wetter5Florian eHolsboer6Philipp Georg Sämann7Sean P.A. Drummond8Sean P.A. Drummond9Max Planck Institute of PsychiatryMax Planck Institute of PsychiatryMax Planck Institute of PsychiatryUniversity of AmsterdamMax Planck Institute of PsychiatryUniversity of ZurichMax Planck Institute of PsychiatryMax Planck Institute of PsychiatryUniversity of CaliforniaVA San Diego Healthcare SystemSleep loss affects attention by reducing levels of arousal and alertness. The neural mechanisms underlying the compensatory efforts of the brain to maintain attention and performance after sleep deprivation are not fully understood. Previous neuroimaging studies of sleep deprivation have not been able to exclude the effects of reduced arousal and vigilance when examining cerebral responses to cognitive challenges. Here, we used a simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) approach to study the effects of 36 hours of total sleep deprivation (TSD). Specifically, we focused on changes in selective attention processes as induced by an active acoustic oddball task, with the ability to isolate runs with objective EEG signs of high or reduced vigilance. At high vigilance, task-related activity appears to be sustained by compensatory co-activation of insular regions, but task-negative activity in the right posterior node of the default mode network is altered following TSD. When EEG shows signs of reduced vigilance, task-positive activity was massively impaired, but task-negative activation was showing levels comparable with the control condition after a well-rested night. Our results suggest that loss of strict anti-correlation between task-positive and task-negative activation reflects the effects of TSD, while the actual state of vigilance and task performance either affects task-related or task-negative activity.http://journal.frontiersin.org/Journal/10.3389/fneur.2012.00067/fullArousalSleep DeprivationEEGfMRIDefault modeMultimodal Imaging |
| spellingShingle | Michael eCzisch Renate eWehrle Helga A Harsay Helga A Harsay Thomas Christian Wetter Thomas Christian Wetter Florian eHolsboer Philipp Georg Sämann Sean P.A. Drummond Sean P.A. Drummond On the need of objective vigilance monitoring: Effects of sleep loss on target detection and task-negative activity using combined EEG/fMRI Frontiers in Neurology Arousal Sleep Deprivation EEG fMRI Default mode Multimodal Imaging |
| title | On the need of objective vigilance monitoring: Effects of sleep loss on target detection and task-negative activity using combined EEG/fMRI |
| title_full | On the need of objective vigilance monitoring: Effects of sleep loss on target detection and task-negative activity using combined EEG/fMRI |
| title_fullStr | On the need of objective vigilance monitoring: Effects of sleep loss on target detection and task-negative activity using combined EEG/fMRI |
| title_full_unstemmed | On the need of objective vigilance monitoring: Effects of sleep loss on target detection and task-negative activity using combined EEG/fMRI |
| title_short | On the need of objective vigilance monitoring: Effects of sleep loss on target detection and task-negative activity using combined EEG/fMRI |
| title_sort | on the need of objective vigilance monitoring effects of sleep loss on target detection and task negative activity using combined eeg fmri |
| topic | Arousal Sleep Deprivation EEG fMRI Default mode Multimodal Imaging |
| url | http://journal.frontiersin.org/Journal/10.3389/fneur.2012.00067/full |
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