Value of diffusion‐weighted imaging in diagnosis and therapy response assessment of hepatic fungal infection in patients with acute leukemia
Abstract Objective To investigate the role of diffusion‐weighted imaging (DWI) for diagnosis and posttreatment assessment of hepatic fungal infection in patients with acute leukemia. Methods Patients with acute leukemia and highly suspected hepatic fungal infection were collected in the study. All t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.843 |
| _version_ | 1826580952624660480 |
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| author | Haoyu Wang Haitao Yu Dong Bai Dan Yao Yongjun Han Yichao Shi Zhiqun Wang |
| author_facet | Haoyu Wang Haitao Yu Dong Bai Dan Yao Yongjun Han Yichao Shi Zhiqun Wang |
| author_sort | Haoyu Wang |
| collection | DOAJ |
| description | Abstract Objective To investigate the role of diffusion‐weighted imaging (DWI) for diagnosis and posttreatment assessment of hepatic fungal infection in patients with acute leukemia. Methods Patients with acute leukemia and highly suspected hepatic fungal infection were collected in the study. All the patients underwent MRI examination, including initial and follow‐up DWI. The apparent diffusion coefficient (ADC) values of the lesions and the normal liver parenchyma were compared using Student's t‐test. The ADC values of the hepatic fungal lesions of pretreatment and posttreatment were compared using paired t‐test. Results A total of 13 patients with hepatic fungal infections have enrolled this study. Hepatic lesions were rounded or oval shaped, measured from 0.3 to 3 cm in diameter. The lesions showed significantly hyperintense signal on DWI and markedly hypointense signal on the ADC map, reflecting a marked restricted diffusion. The mean ADC values of the lesions were significantly lower than those of normal liver parenchyma (1.08 ± 0.34 × 10−3 vs. 1.98 ± 0.12 × 10−3 mm2/s, p < 0.001). After treatment, the mean ADC values of the lesions were significantly increased when comparing with those of pretreatment (1.39 ± 0.29 × 10−3 vs. 1.06 ± 0.10 × 10−3 mm2/s, p = .016). Conclusion DWI can provide diffusion information of hepatic fungal infection in patients with acute leukemia, which could be taken as a valuable tool for diagnosis and therapy response assessment of these patients. |
| first_indexed | 2024-04-09T13:43:51Z |
| format | Article |
| id | doaj.art-424d16e7bb3840a8be36e144ad82f975 |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2025-03-14T14:42:21Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-424d16e7bb3840a8be36e144ad82f9752025-02-25T20:57:40ZengWileyImmunity, Inflammation and Disease2050-45272023-04-01114n/an/a10.1002/iid3.843Value of diffusion‐weighted imaging in diagnosis and therapy response assessment of hepatic fungal infection in patients with acute leukemiaHaoyu Wang0Haitao Yu1Dong Bai2Dan Yao3Yongjun Han4Yichao Shi5Zhiqun Wang6Department of Radiology Aerospace Center Hospital Beijing ChinaDepartment of Radiology Aerospace Center Hospital Beijing ChinaDepartment of Radiology Aerospace Center Hospital Beijing ChinaDepartment of Radiology Aerospace Center Hospital Beijing ChinaDepartment of Radiology Aerospace Center Hospital Beijing ChinaDepartment of Gastroenterology Aerospace Center Hospital Beijing ChinaDepartment of Radiology Aerospace Center Hospital Beijing ChinaAbstract Objective To investigate the role of diffusion‐weighted imaging (DWI) for diagnosis and posttreatment assessment of hepatic fungal infection in patients with acute leukemia. Methods Patients with acute leukemia and highly suspected hepatic fungal infection were collected in the study. All the patients underwent MRI examination, including initial and follow‐up DWI. The apparent diffusion coefficient (ADC) values of the lesions and the normal liver parenchyma were compared using Student's t‐test. The ADC values of the hepatic fungal lesions of pretreatment and posttreatment were compared using paired t‐test. Results A total of 13 patients with hepatic fungal infections have enrolled this study. Hepatic lesions were rounded or oval shaped, measured from 0.3 to 3 cm in diameter. The lesions showed significantly hyperintense signal on DWI and markedly hypointense signal on the ADC map, reflecting a marked restricted diffusion. The mean ADC values of the lesions were significantly lower than those of normal liver parenchyma (1.08 ± 0.34 × 10−3 vs. 1.98 ± 0.12 × 10−3 mm2/s, p < 0.001). After treatment, the mean ADC values of the lesions were significantly increased when comparing with those of pretreatment (1.39 ± 0.29 × 10−3 vs. 1.06 ± 0.10 × 10−3 mm2/s, p = .016). Conclusion DWI can provide diffusion information of hepatic fungal infection in patients with acute leukemia, which could be taken as a valuable tool for diagnosis and therapy response assessment of these patients.https://doi.org/10.1002/iid3.843acute leukemiadiffusion‐weighted imaginghepatic fungal infection |
| spellingShingle | Haoyu Wang Haitao Yu Dong Bai Dan Yao Yongjun Han Yichao Shi Zhiqun Wang Value of diffusion‐weighted imaging in diagnosis and therapy response assessment of hepatic fungal infection in patients with acute leukemia Immunity, Inflammation and Disease acute leukemia diffusion‐weighted imaging hepatic fungal infection |
| title | Value of diffusion‐weighted imaging in diagnosis and therapy response assessment of hepatic fungal infection in patients with acute leukemia |
| title_full | Value of diffusion‐weighted imaging in diagnosis and therapy response assessment of hepatic fungal infection in patients with acute leukemia |
| title_fullStr | Value of diffusion‐weighted imaging in diagnosis and therapy response assessment of hepatic fungal infection in patients with acute leukemia |
| title_full_unstemmed | Value of diffusion‐weighted imaging in diagnosis and therapy response assessment of hepatic fungal infection in patients with acute leukemia |
| title_short | Value of diffusion‐weighted imaging in diagnosis and therapy response assessment of hepatic fungal infection in patients with acute leukemia |
| title_sort | value of diffusion weighted imaging in diagnosis and therapy response assessment of hepatic fungal infection in patients with acute leukemia |
| topic | acute leukemia diffusion‐weighted imaging hepatic fungal infection |
| url | https://doi.org/10.1002/iid3.843 |
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