Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile

Abstract Severe outbreaks and deaths have been linked to the emergence and global spread of fluoroquinolone-resistant Clostridioides difficile over the past two decades. At the same time, metronidazole, a nitro-containing antibiotic, has shown decreasing clinical efficacy in treating C. difficile in...

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Bibliographic Details
Main Authors: Abiola O. Olaitan, Chetna Dureja, Madison A. Youngblom, Madeline A. Topf, Wan-Jou Shen, Anne J. Gonzales-Luna, Aditi Deshpande, Kirk E. Hevener, Jane Freeman, Mark H. Wilcox, Kelli L. Palmer, Kevin W. Garey, Caitlin S. Pepperell, Julian G. Hurdle
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39429-x

Internet

https://doi.org/10.1038/s41467-023-39429-x

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