Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge
Although ofloxacin-ornidazole fixed-dose combination (FDC) is a rampantly used antibiotic combination for mixed-infection diarrhea in India, the adverse drug reaction (ADR) associated with these FDCs remains underreported. Herein, the authors present a case report of a definitive ofloxacin-ornidazol...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2020-01-01
|
| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2020;volume=9;issue=6;spage=3157;epage=3159;aulast= |
| _version_ | 1818313499734966272 |
|---|---|
| author | Nikhil Bush Vishal Sharma K Chandrahasan Amol N Patil |
| author_facet | Nikhil Bush Vishal Sharma K Chandrahasan Amol N Patil |
| author_sort | Nikhil Bush |
| collection | DOAJ |
| description | Although ofloxacin-ornidazole fixed-dose combination (FDC) is a rampantly used antibiotic combination for mixed-infection diarrhea in India, the adverse drug reaction (ADR) associated with these FDCs remains underreported. Herein, the authors present a case report of a definitive ofloxacin-ornidazole FDC-induced pancreatitis. The nonalcoholic adult male patient showed a sharp piercing epigastric pain flowing to the back, gradually rising in severity, which started after taking ofloxacin-ornidazole FDC tablet over the counter. Serum lipase concentration measured in the emergency room was 635 units per liter (normal range- 13–60 units/L) and serum amylase was 377 units/L (normal range- 30–110 units/L). Ultrasonography and an axial computed tomography of the abdomen confirmed the diagnosis of acute pancreatitis. Ofloxacin-ornidazole FDC tablet was stopped immediately. Past treatment records confirmed accidental rechallenge. In conclusion, this is a first case report of ofloxacin-ornidazole FDC-induced pancreatitis. |
| first_indexed | 2024-12-13T08:34:43Z |
| format | Article |
| id | doaj.art-42509c49ae264f3881aa0135f7d53076 |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-12-13T08:34:43Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-42509c49ae264f3881aa0135f7d530762022-12-21T23:53:40ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632020-01-01963157315910.4103/jfmpc.jfmpc_531_20Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallengeNikhil BushVishal SharmaK ChandrahasanAmol N PatilAlthough ofloxacin-ornidazole fixed-dose combination (FDC) is a rampantly used antibiotic combination for mixed-infection diarrhea in India, the adverse drug reaction (ADR) associated with these FDCs remains underreported. Herein, the authors present a case report of a definitive ofloxacin-ornidazole FDC-induced pancreatitis. The nonalcoholic adult male patient showed a sharp piercing epigastric pain flowing to the back, gradually rising in severity, which started after taking ofloxacin-ornidazole FDC tablet over the counter. Serum lipase concentration measured in the emergency room was 635 units per liter (normal range- 13–60 units/L) and serum amylase was 377 units/L (normal range- 30–110 units/L). Ultrasonography and an axial computed tomography of the abdomen confirmed the diagnosis of acute pancreatitis. Ofloxacin-ornidazole FDC tablet was stopped immediately. Past treatment records confirmed accidental rechallenge. In conclusion, this is a first case report of ofloxacin-ornidazole FDC-induced pancreatitis.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2020;volume=9;issue=6;spage=3157;epage=3159;aulast=adverse eventofloxacinornidazolepancreatitispositive rechallenge |
| spellingShingle | Nikhil Bush Vishal Sharma K Chandrahasan Amol N Patil Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge Journal of Family Medicine and Primary Care adverse event ofloxacin ornidazole pancreatitis positive rechallenge |
| title | Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge |
| title_full | Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge |
| title_fullStr | Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge |
| title_full_unstemmed | Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge |
| title_short | Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge |
| title_sort | ofloxacin ornidazole fixed dose combination medication induced pancreatitis with positive rechallenge |
| topic | adverse event ofloxacin ornidazole pancreatitis positive rechallenge |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2020;volume=9;issue=6;spage=3157;epage=3159;aulast= |
| work_keys_str_mv | AT nikhilbush ofloxacinornidazolefixeddosecombinationmedicationinducedpancreatitiswithpositiverechallenge AT vishalsharma ofloxacinornidazolefixeddosecombinationmedicationinducedpancreatitiswithpositiverechallenge AT kchandrahasan ofloxacinornidazolefixeddosecombinationmedicationinducedpancreatitiswithpositiverechallenge AT amolnpatil ofloxacinornidazolefixeddosecombinationmedicationinducedpancreatitiswithpositiverechallenge |