In Situ Pre-Treatment of Vascularized Composite Allografts With a Targeted Complement Inhibitor Protects Against Brain Death and Ischemia Reperfusion Induced Injuries

In Situ Pre-Treatment of Vascularized Composite Allografts With a Targeted Complement Inhibitor Protects Against Brain Death and Ischemia Reperfusion Induced Injuries

IntroductionDonor brain death (BD) is an unavoidable component of vascularized composite allograft (VCA) transplantation and a key contributor to ischemia-reperfusion injury (IRI). Complement is activated and deposited within solid organ grafts as a consequence of BD and has been shown to exacerbate...

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Bibliographic Details
Main Authors: Biao Lei, M. Mahdi Sleiman, Qi Cheng, Zhenxiao Tu, Peng Zhu, Martin Goddard, Paulo N. Martins, Logan Langerude, Satish Nadig, Stephen Tomlinson, Carl Atkinson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
vascularized composite allotransplantation
graft treatment
transplantation
complement inhibition
brain death
ischemia reperfusion injury
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.630581/full

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