Experimental Models to Study Endothelial to Mesenchymal Transition in Myocardial Fibrosis and Cardiovascular Diseases
Fibrosis is a common feature of cardiovascular diseases and targets multiple organs, such as the heart and vessels. Endothelial to mesenchymal transition is a complex, vital process that occurs during embryonic formation and plays a crucial role in cardiac development. It is also a fundamental proce...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/1/382 |
| _version_ | 1797358654958075904 |
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| author | Mohammed Mimouni Anne-Dominique Lajoix Caroline Desmetz |
| author_facet | Mohammed Mimouni Anne-Dominique Lajoix Caroline Desmetz |
| author_sort | Mohammed Mimouni |
| collection | DOAJ |
| description | Fibrosis is a common feature of cardiovascular diseases and targets multiple organs, such as the heart and vessels. Endothelial to mesenchymal transition is a complex, vital process that occurs during embryonic formation and plays a crucial role in cardiac development. It is also a fundamental process implicated in cardiac fibrosis and repair, but also in other organs. Indeed, in numerous cardiovascular diseases, the endothelial-to-mesenchymal transition has been shown to be involved in the generation of fibroblasts that are able to produce extracellular matrix proteins such as type I collagen. This massive deposition results in tissue stiffening and organ dysfunction. To advance our understanding of this process for the development of new specific diagnostic and therapeutic strategies, it is essential to develop relevant cellular and animal models of this process. In this review, our aim was to gain an in-depth insight into existing in vitro and in vivo models of endothelial to mesenchymal transition in cardiovascular diseases with a focus on cardiac fibrosis. We discuss important parameters impacting endothelial to mesenchymal transition, and we give perspectives for the development of relevant models to decipher the underlying mechanisms and ultimately find new treatments specific to fibrosis happening in cardiovascular diseases. |
| first_indexed | 2024-03-08T15:05:11Z |
| format | Article |
| id | doaj.art-4254b3800a364743832bb5e51fdb9c3a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T15:05:11Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4254b3800a364743832bb5e51fdb9c3a2024-01-10T14:59:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0125138210.3390/ijms25010382Experimental Models to Study Endothelial to Mesenchymal Transition in Myocardial Fibrosis and Cardiovascular DiseasesMohammed Mimouni0Anne-Dominique Lajoix1Caroline Desmetz2Biocommunication in Cardio-Metabolism (BC2M), University of Montpellier, 34000 Montpellier, FranceBiocommunication in Cardio-Metabolism (BC2M), University of Montpellier, 34000 Montpellier, FranceBiocommunication in Cardio-Metabolism (BC2M), University of Montpellier, 34000 Montpellier, FranceFibrosis is a common feature of cardiovascular diseases and targets multiple organs, such as the heart and vessels. Endothelial to mesenchymal transition is a complex, vital process that occurs during embryonic formation and plays a crucial role in cardiac development. It is also a fundamental process implicated in cardiac fibrosis and repair, but also in other organs. Indeed, in numerous cardiovascular diseases, the endothelial-to-mesenchymal transition has been shown to be involved in the generation of fibroblasts that are able to produce extracellular matrix proteins such as type I collagen. This massive deposition results in tissue stiffening and organ dysfunction. To advance our understanding of this process for the development of new specific diagnostic and therapeutic strategies, it is essential to develop relevant cellular and animal models of this process. In this review, our aim was to gain an in-depth insight into existing in vitro and in vivo models of endothelial to mesenchymal transition in cardiovascular diseases with a focus on cardiac fibrosis. We discuss important parameters impacting endothelial to mesenchymal transition, and we give perspectives for the development of relevant models to decipher the underlying mechanisms and ultimately find new treatments specific to fibrosis happening in cardiovascular diseases.https://www.mdpi.com/1422-0067/25/1/382fibrosiscardiovascular diseaseendothelial to mesenchymal transitionin vitro modelsanimal models |
| spellingShingle | Mohammed Mimouni Anne-Dominique Lajoix Caroline Desmetz Experimental Models to Study Endothelial to Mesenchymal Transition in Myocardial Fibrosis and Cardiovascular Diseases International Journal of Molecular Sciences fibrosis cardiovascular disease endothelial to mesenchymal transition in vitro models animal models |
| title | Experimental Models to Study Endothelial to Mesenchymal Transition in Myocardial Fibrosis and Cardiovascular Diseases |
| title_full | Experimental Models to Study Endothelial to Mesenchymal Transition in Myocardial Fibrosis and Cardiovascular Diseases |
| title_fullStr | Experimental Models to Study Endothelial to Mesenchymal Transition in Myocardial Fibrosis and Cardiovascular Diseases |
| title_full_unstemmed | Experimental Models to Study Endothelial to Mesenchymal Transition in Myocardial Fibrosis and Cardiovascular Diseases |
| title_short | Experimental Models to Study Endothelial to Mesenchymal Transition in Myocardial Fibrosis and Cardiovascular Diseases |
| title_sort | experimental models to study endothelial to mesenchymal transition in myocardial fibrosis and cardiovascular diseases |
| topic | fibrosis cardiovascular disease endothelial to mesenchymal transition in vitro models animal models |
| url | https://www.mdpi.com/1422-0067/25/1/382 |
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