Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating.
Brain-derived neurotrophic factor (BDNF) plays a key role in neuronal adaptations. While previous studies suggest that whole-body heating can elevate circulating BDNF concentration, this is not known for local heating protocols. This study investigated the acute effects of whole-body versus local pa...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0260775 |
| _version_ | 1798035898872365056 |
|---|---|
| author | Takahiro Ogawa Sven P Hoekstra Yoshi-Ichiro Kamijo Victoria L Goosey-Tolfrey Jeremy J Walsh Fumihiro Tajima F Christof A Leicht |
| author_facet | Takahiro Ogawa Sven P Hoekstra Yoshi-Ichiro Kamijo Victoria L Goosey-Tolfrey Jeremy J Walsh Fumihiro Tajima F Christof A Leicht |
| author_sort | Takahiro Ogawa |
| collection | DOAJ |
| description | Brain-derived neurotrophic factor (BDNF) plays a key role in neuronal adaptations. While previous studies suggest that whole-body heating can elevate circulating BDNF concentration, this is not known for local heating protocols. This study investigated the acute effects of whole-body versus local passive heating on serum and plasma BDNF concentration. Using a water-perfused suit, ten recreationally active males underwent three 90 min experimental protocols: heating of the legs with upper-body cooling (LBH), whole-body heating (WBH) and a control condition (CON). Blood samples were collected before, immediately after and 1 h post-heating for the determination of serum and plasma BDNF concentration, platelet count as well as the BDNF release per platelet. Rectal temperature, cardiac output and femoral artery shear rate were assessed at regular intervals. Serum and plasma BDNF concentration were elevated after WBH (serum: 19.1±5.0 to 25.9±11.3 ng/ml, plasma: 2.74±0.9 to 4.58±2.0; p<0.044), but not LBH (serum: 19.1±4.7 to 22.3±4.8 ng/ml, plasma: 3.25±1.13 to 3.39±0.90 ng/ml; p>0.126), when compared with CON (serum: 18.6±6.4 to 16.8±3.4 ng/ml, plasma: 2.49±0.69 to 2.82±0.89 ng/ml); accompanied by an increase in platelet count (p<0.001). However, there was no change in BDNF content per platelet after either condition (p = 0.392). All physiological measures were elevated to a larger extent after WBH compared with LBH (p<0.001), while shear rate and rectal temperature were higher during LBH than CON (p<0.038). In conclusion, WBH but not LBH acutely elevates circulating BDNF concentration. While these findings further support the use of passive heating to elevate BDNF concentration, a larger increase in shear rate, sympathetic activity and/or rectal temperature than found after LBH appears needed to induce an acute BDNF response by passive heating. |
| first_indexed | 2024-04-11T21:04:44Z |
| format | Article |
| id | doaj.art-42562c4147644afba568c79c7562d1b4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T21:04:44Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-42562c4147644afba568c79c7562d1b42022-12-22T04:03:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011612e026077510.1371/journal.pone.0260775Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating.Takahiro OgawaSven P HoekstraYoshi-Ichiro KamijoVictoria L Goosey-TolfreyJeremy J WalshFumihiro Tajima FChristof A LeichtBrain-derived neurotrophic factor (BDNF) plays a key role in neuronal adaptations. While previous studies suggest that whole-body heating can elevate circulating BDNF concentration, this is not known for local heating protocols. This study investigated the acute effects of whole-body versus local passive heating on serum and plasma BDNF concentration. Using a water-perfused suit, ten recreationally active males underwent three 90 min experimental protocols: heating of the legs with upper-body cooling (LBH), whole-body heating (WBH) and a control condition (CON). Blood samples were collected before, immediately after and 1 h post-heating for the determination of serum and plasma BDNF concentration, platelet count as well as the BDNF release per platelet. Rectal temperature, cardiac output and femoral artery shear rate were assessed at regular intervals. Serum and plasma BDNF concentration were elevated after WBH (serum: 19.1±5.0 to 25.9±11.3 ng/ml, plasma: 2.74±0.9 to 4.58±2.0; p<0.044), but not LBH (serum: 19.1±4.7 to 22.3±4.8 ng/ml, plasma: 3.25±1.13 to 3.39±0.90 ng/ml; p>0.126), when compared with CON (serum: 18.6±6.4 to 16.8±3.4 ng/ml, plasma: 2.49±0.69 to 2.82±0.89 ng/ml); accompanied by an increase in platelet count (p<0.001). However, there was no change in BDNF content per platelet after either condition (p = 0.392). All physiological measures were elevated to a larger extent after WBH compared with LBH (p<0.001), while shear rate and rectal temperature were higher during LBH than CON (p<0.038). In conclusion, WBH but not LBH acutely elevates circulating BDNF concentration. While these findings further support the use of passive heating to elevate BDNF concentration, a larger increase in shear rate, sympathetic activity and/or rectal temperature than found after LBH appears needed to induce an acute BDNF response by passive heating.https://doi.org/10.1371/journal.pone.0260775 |
| spellingShingle | Takahiro Ogawa Sven P Hoekstra Yoshi-Ichiro Kamijo Victoria L Goosey-Tolfrey Jeremy J Walsh Fumihiro Tajima F Christof A Leicht Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating. PLoS ONE |
| title | Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating. |
| title_full | Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating. |
| title_fullStr | Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating. |
| title_full_unstemmed | Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating. |
| title_short | Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating. |
| title_sort | serum and plasma brain derived neurotrophic factor concentration are elevated by systemic but not local passive heating |
| url | https://doi.org/10.1371/journal.pone.0260775 |
| work_keys_str_mv | AT takahiroogawa serumandplasmabrainderivedneurotrophicfactorconcentrationareelevatedbysystemicbutnotlocalpassiveheating AT svenphoekstra serumandplasmabrainderivedneurotrophicfactorconcentrationareelevatedbysystemicbutnotlocalpassiveheating AT yoshiichirokamijo serumandplasmabrainderivedneurotrophicfactorconcentrationareelevatedbysystemicbutnotlocalpassiveheating AT victorialgooseytolfrey serumandplasmabrainderivedneurotrophicfactorconcentrationareelevatedbysystemicbutnotlocalpassiveheating AT jeremyjwalsh serumandplasmabrainderivedneurotrophicfactorconcentrationareelevatedbysystemicbutnotlocalpassiveheating AT fumihirotajimaf serumandplasmabrainderivedneurotrophicfactorconcentrationareelevatedbysystemicbutnotlocalpassiveheating AT christofaleicht serumandplasmabrainderivedneurotrophicfactorconcentrationareelevatedbysystemicbutnotlocalpassiveheating |