Biomarkers in IBD: What to Utilize for the Diagnosis?
The role of biomarkers in the diagnosis of inflammatory bowel disease is not fully characterized. C-reactive protein has a short half-life and elevates quickly after the onset of an inflammatory process; the performance is better in Crohn’s disease than in ulcerative colitis. Erythrocyte sedimentati...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/18/2931 |
| _version_ | 1797580598136537088 |
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| author | Renata D’Incà Giulia Sturniolo |
| author_facet | Renata D’Incà Giulia Sturniolo |
| author_sort | Renata D’Incà |
| collection | DOAJ |
| description | The role of biomarkers in the diagnosis of inflammatory bowel disease is not fully characterized. C-reactive protein has a short half-life and elevates quickly after the onset of an inflammatory process; the performance is better in Crohn’s disease than in ulcerative colitis. Erythrocyte sedimentation rate is easy to determine, widely available, and cheap, but the long half-life, the influence of age, anemia, smoking, and drugs limit its usefulness. Fecal markers have good specificity, but suboptimal accuracy. Microbial antibodies and novel immunological markers show promise but need further evidence before entering clinical practice. Proteomic methods could represent the dawn of a new era of stool protein/peptide biomarker panels able to select patients at risk of inflammatory bowel disease. |
| first_indexed | 2024-03-10T22:52:00Z |
| format | Article |
| id | doaj.art-42568141c3f74eb8958130383da0adb2 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T22:52:00Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-42568141c3f74eb8958130383da0adb22023-11-19T10:13:34ZengMDPI AGDiagnostics2075-44182023-09-011318293110.3390/diagnostics13182931Biomarkers in IBD: What to Utilize for the Diagnosis?Renata D’Incà0Giulia Sturniolo1Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, 35124 Padua, ItalyDepartment of Women’s and Children’s Health, University of Padua, 35128 Padova, ItalyThe role of biomarkers in the diagnosis of inflammatory bowel disease is not fully characterized. C-reactive protein has a short half-life and elevates quickly after the onset of an inflammatory process; the performance is better in Crohn’s disease than in ulcerative colitis. Erythrocyte sedimentation rate is easy to determine, widely available, and cheap, but the long half-life, the influence of age, anemia, smoking, and drugs limit its usefulness. Fecal markers have good specificity, but suboptimal accuracy. Microbial antibodies and novel immunological markers show promise but need further evidence before entering clinical practice. Proteomic methods could represent the dawn of a new era of stool protein/peptide biomarker panels able to select patients at risk of inflammatory bowel disease.https://www.mdpi.com/2075-4418/13/18/2931fecal calprotectinC-reactive proteinp-ANCAASCA |
| spellingShingle | Renata D’Incà Giulia Sturniolo Biomarkers in IBD: What to Utilize for the Diagnosis? Diagnostics fecal calprotectin C-reactive protein p-ANCA ASCA |
| title | Biomarkers in IBD: What to Utilize for the Diagnosis? |
| title_full | Biomarkers in IBD: What to Utilize for the Diagnosis? |
| title_fullStr | Biomarkers in IBD: What to Utilize for the Diagnosis? |
| title_full_unstemmed | Biomarkers in IBD: What to Utilize for the Diagnosis? |
| title_short | Biomarkers in IBD: What to Utilize for the Diagnosis? |
| title_sort | biomarkers in ibd what to utilize for the diagnosis |
| topic | fecal calprotectin C-reactive protein p-ANCA ASCA |
| url | https://www.mdpi.com/2075-4418/13/18/2931 |
| work_keys_str_mv | AT renatadinca biomarkersinibdwhattoutilizeforthediagnosis AT giuliasturniolo biomarkersinibdwhattoutilizeforthediagnosis |