Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton
Atherosclerosis is a coronary disease where deposition of lipids in the arteries leads to problems of blood circulation. The present work evaluates the action of the flavonoids morin, quercetin and nicotinic acid isolated in association on lipid metabolism in hyperlipidemic rats. Blood serum levels...
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| Format: | Article |
| Language: | English |
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Instituto de Tecnologia do Paraná (Tecpar)
2001-09-01
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| Series: | Brazilian Archives of Biology and Technology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132001000300007 |
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| author | Kelly Fabiane Santos Ricardo Tânia Toledo de Oliveira Tanus Jorge Nagem Aloisio da Silva Pinto Maria Goreti Almeida Oliveira José Francisco Soares |
| author_facet | Kelly Fabiane Santos Ricardo Tânia Toledo de Oliveira Tanus Jorge Nagem Aloisio da Silva Pinto Maria Goreti Almeida Oliveira José Francisco Soares |
| author_sort | Kelly Fabiane Santos Ricardo |
| collection | DOAJ |
| description | Atherosclerosis is a coronary disease where deposition of lipids in the arteries leads to problems of blood circulation. The present work evaluates the action of the flavonoids morin, quercetin and nicotinic acid isolated in association on lipid metabolism in hyperlipidemic rats. Blood serum levels cholesterol, cholesterol-HDL, and triacylglycerids have been analysed following the intraperitoneal administration of the flavonoid compounds dissolved in propyleneglycol by in doses of 5mg/kg body weight. Quercetin presented the largest percentual reduction of cholesterol. The best results for cholesterol-HDL have been obtained with-nicotinic acid alone while morin-nicotinic acid combination showed the best triacylglycerols results. Results showed that flavonoids could be beneficious in the treatment of coronary diseases.<br>Aterosclerose é uma doença coronária onde a deposição de lipídeos nas artérias leva a problemas na circulação sangüínea. O presente trabalho avalia a ação dos flavonóides morina, quercetina e ácido nicotínico isoladamente e em associação no metabolismo lipídico em ratos hiperlipidêmicos. Foram analisados os níveis de colesterol, colesterol- HDL e triacilgliceróis no soro sangüíneo após administração, via intraperitoneal, dos compostos flavonoídicos dissolvidos em propileno glicol na dose de 5mg/kg de peso corporal. Quercetina mostrou o maior percentual de redução do colesterol. Para colesterol-HDL, os melhores resultados foram obtidos com ácido nicotínico isoladamente, enquanto a associação morina-ácido nicotínico mostrou os melhores resultados para triacilgliceróis. Os resultados mostraram que os flavonóides podem ser benéficos no tratamento de doença coronoriana. |
| first_indexed | 2024-12-11T09:36:11Z |
| format | Article |
| id | doaj.art-42569c7bf8d5434086f7c24ff76922ef |
| institution | Directory Open Access Journal |
| issn | 1516-8913 1678-4324 |
| language | English |
| last_indexed | 2024-12-11T09:36:11Z |
| publishDate | 2001-09-01 |
| publisher | Instituto de Tecnologia do Paraná (Tecpar) |
| record_format | Article |
| series | Brazilian Archives of Biology and Technology |
| spelling | doaj.art-42569c7bf8d5434086f7c24ff76922ef2022-12-22T01:12:50ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1516-89131678-43242001-09-0144326326710.1590/S1516-89132001000300007Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with tritonKelly Fabiane Santos RicardoTânia Toledo de OliveiraTanus Jorge NagemAloisio da Silva PintoMaria Goreti Almeida OliveiraJosé Francisco SoaresAtherosclerosis is a coronary disease where deposition of lipids in the arteries leads to problems of blood circulation. The present work evaluates the action of the flavonoids morin, quercetin and nicotinic acid isolated in association on lipid metabolism in hyperlipidemic rats. Blood serum levels cholesterol, cholesterol-HDL, and triacylglycerids have been analysed following the intraperitoneal administration of the flavonoid compounds dissolved in propyleneglycol by in doses of 5mg/kg body weight. Quercetin presented the largest percentual reduction of cholesterol. The best results for cholesterol-HDL have been obtained with-nicotinic acid alone while morin-nicotinic acid combination showed the best triacylglycerols results. Results showed that flavonoids could be beneficious in the treatment of coronary diseases.<br>Aterosclerose é uma doença coronária onde a deposição de lipídeos nas artérias leva a problemas na circulação sangüínea. O presente trabalho avalia a ação dos flavonóides morina, quercetina e ácido nicotínico isoladamente e em associação no metabolismo lipídico em ratos hiperlipidêmicos. Foram analisados os níveis de colesterol, colesterol- HDL e triacilgliceróis no soro sangüíneo após administração, via intraperitoneal, dos compostos flavonoídicos dissolvidos em propileno glicol na dose de 5mg/kg de peso corporal. Quercetina mostrou o maior percentual de redução do colesterol. Para colesterol-HDL, os melhores resultados foram obtidos com ácido nicotínico isoladamente, enquanto a associação morina-ácido nicotínico mostrou os melhores resultados para triacilgliceróis. Os resultados mostraram que os flavonóides podem ser benéficos no tratamento de doença coronoriana.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132001000300007MorinQuercetinNicotinic AcidLipidCholesterolCholesterol-HDLTriacylglycerolsRatsHyperlipidemic |
| spellingShingle | Kelly Fabiane Santos Ricardo Tânia Toledo de Oliveira Tanus Jorge Nagem Aloisio da Silva Pinto Maria Goreti Almeida Oliveira José Francisco Soares Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton Brazilian Archives of Biology and Technology Morin Quercetin Nicotinic Acid Lipid Cholesterol Cholesterol-HDL Triacylglycerols Rats Hyperlipidemic |
| title | Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton |
| title_full | Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton |
| title_fullStr | Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton |
| title_full_unstemmed | Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton |
| title_short | Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton |
| title_sort | effect of flavonoids morin quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton |
| topic | Morin Quercetin Nicotinic Acid Lipid Cholesterol Cholesterol-HDL Triacylglycerols Rats Hyperlipidemic |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132001000300007 |
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