Sumoylation of SAP130 regulates its interaction with FAF1 as well as its protein stability and transcriptional repressor function

Sumoylation of SAP130 regulates its interaction with FAF1 as well as its protein stability and transcriptional repressor function

Abstract Background Fas-associated factor 1 (FAF1) is a multidomain protein that interacts with diverse partners to affect numerous cellular processes. Previously, we discovered two Small Ubiquitin-like Modifier (SUMO)-interacting motifs (SIMs) within FAF1 that are crucial for transcriptional modula...

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Bibliographic Details
Main Authors: Chang-Han Chen, Hung-Wei Lin, Meng-Fang Huang, Chi-Wu Chiang, Kuen-Haur Lee, Nguyen Thanh Phuong, Zong-Yan Cai, Wen-Chang Chang, Ding-Yen Lin
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Molecular and Cell Biology
Subjects:
SAP130
FAF1
Sumoylation
SUMO-interacting motifs (SIMs)
Online Access:https://doi.org/10.1186/s12860-023-00498-x

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