Association Between Interpregnancy Interval and Risk of Preterm Birth and Its Modification by Folate Intake: The Japan Environment and Children’s Study
Background: Both short and long interpregnancy intervals (IPIs) have been associated with risk of preterm birth, but the evidence is limited in Asians. It is also uncertain whether the association is modified by dietary folate intake or folic acid supplementation during pregnancy. Thus, we examined...
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| Format: | Article |
| Language: | English |
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Japan Epidemiological Association
2023-03-01
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| Series: | Journal of Epidemiology |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jea/33/3/33_JE20210031/_pdf |
| _version_ | 1797851705441779712 |
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| author | Kanami Tanigawa Satoyo Ikehara Meishan Cui Yoko Kawanishi Tadashi Kimura Kimiko Ueda Kazumasa Yamagishi Hiroyasu Iso |
| author_facet | Kanami Tanigawa Satoyo Ikehara Meishan Cui Yoko Kawanishi Tadashi Kimura Kimiko Ueda Kazumasa Yamagishi Hiroyasu Iso |
| author_sort | Kanami Tanigawa |
| collection | DOAJ |
| description | Background: Both short and long interpregnancy intervals (IPIs) have been associated with risk of preterm birth, but the evidence is limited in Asians. It is also uncertain whether the association is modified by dietary folate intake or folic acid supplementation during pregnancy. Thus, we examined associations between IPI and risk of preterm birth and effect modification of those associations by dietary intake of folate and supplementation with folic acid on the basis of a nationwide birth cohort study. Methods: Among 103,062 pregnancies registered in the Japan Environment and Children’s Study, 55,203 singleton live-birth pregnancies were included in the analysis. We calculated IPI using birth date, gestational age at birth of offspring, and birth data of the latest offspring. Odds ratios (ORs) and 95% confidence intervals (CIs) of the risk of preterm birth were estimated according to IPI categories. Results: Both <6-month and ≥120-month IPIs were associated with an increased risk of preterm birth, compared with an 18–23-month IPI. The multivariable ORs were 1.63 (95% CI, 1.30–2.04) for <6-month and 1.41 (95% CI, 1.11–1.79) for ≥120-month IPIs. These associations were confined to women with inadequate intake of dietary folate and folic acid supplementation during pregnancy. Multivariable ORs were 1.76 (95% CI, 1.35–2.29) for <6-month IPI and 1.65 (95% CI, 1.24–2.19) for ≥120-month IPI. Conclusion: Both <6-month and ≥120-month IPIs were associated with an increased risk of preterm birth. These higher risks were confined to women with inadequate intake of dietary folate and folic acid supplementation during pregnancy. |
| first_indexed | 2024-04-09T19:22:10Z |
| format | Article |
| id | doaj.art-425b9bc69987415282385fefc8dc6706 |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-04-09T19:22:10Z |
| publishDate | 2023-03-01 |
| publisher | Japan Epidemiological Association |
| record_format | Article |
| series | Journal of Epidemiology |
| spelling | doaj.art-425b9bc69987415282385fefc8dc67062023-04-05T08:28:46ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922023-03-0133311311910.2188/jea.JE20210031Association Between Interpregnancy Interval and Risk of Preterm Birth and Its Modification by Folate Intake: The Japan Environment and Children’s StudyKanami Tanigawa0Satoyo Ikehara1Meishan Cui2Yoko Kawanishi3Tadashi Kimura4Kimiko Ueda5Kazumasa Yamagishi6Hiroyasu Iso7Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, JapanPublic Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, JapanPublic Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, JapanDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, JapanDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, JapanOsaka Maternal and Child Health Information Center, Osaka Women’s and Children’s Hospital, Osaka, JapanDepartment of Public Health Medicine, Faculty of Medicine, and Health Services Research and Development Center, University of Tsukuba, Ibaraki, JapanPublic Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, JapanBackground: Both short and long interpregnancy intervals (IPIs) have been associated with risk of preterm birth, but the evidence is limited in Asians. It is also uncertain whether the association is modified by dietary folate intake or folic acid supplementation during pregnancy. Thus, we examined associations between IPI and risk of preterm birth and effect modification of those associations by dietary intake of folate and supplementation with folic acid on the basis of a nationwide birth cohort study. Methods: Among 103,062 pregnancies registered in the Japan Environment and Children’s Study, 55,203 singleton live-birth pregnancies were included in the analysis. We calculated IPI using birth date, gestational age at birth of offspring, and birth data of the latest offspring. Odds ratios (ORs) and 95% confidence intervals (CIs) of the risk of preterm birth were estimated according to IPI categories. Results: Both <6-month and ≥120-month IPIs were associated with an increased risk of preterm birth, compared with an 18–23-month IPI. The multivariable ORs were 1.63 (95% CI, 1.30–2.04) for <6-month and 1.41 (95% CI, 1.11–1.79) for ≥120-month IPIs. These associations were confined to women with inadequate intake of dietary folate and folic acid supplementation during pregnancy. Multivariable ORs were 1.76 (95% CI, 1.35–2.29) for <6-month IPI and 1.65 (95% CI, 1.24–2.19) for ≥120-month IPI. Conclusion: Both <6-month and ≥120-month IPIs were associated with an increased risk of preterm birth. These higher risks were confined to women with inadequate intake of dietary folate and folic acid supplementation during pregnancy.https://www.jstage.jst.go.jp/article/jea/33/3/33_JE20210031/_pdfinterpregnancy intervalpreterm birthfolatefolic acidprospective studies |
| spellingShingle | Kanami Tanigawa Satoyo Ikehara Meishan Cui Yoko Kawanishi Tadashi Kimura Kimiko Ueda Kazumasa Yamagishi Hiroyasu Iso Association Between Interpregnancy Interval and Risk of Preterm Birth and Its Modification by Folate Intake: The Japan Environment and Children’s Study Journal of Epidemiology interpregnancy interval preterm birth folate folic acid prospective studies |
| title | Association Between Interpregnancy Interval and Risk of Preterm Birth and Its Modification by Folate Intake: The Japan Environment and Children’s Study |
| title_full | Association Between Interpregnancy Interval and Risk of Preterm Birth and Its Modification by Folate Intake: The Japan Environment and Children’s Study |
| title_fullStr | Association Between Interpregnancy Interval and Risk of Preterm Birth and Its Modification by Folate Intake: The Japan Environment and Children’s Study |
| title_full_unstemmed | Association Between Interpregnancy Interval and Risk of Preterm Birth and Its Modification by Folate Intake: The Japan Environment and Children’s Study |
| title_short | Association Between Interpregnancy Interval and Risk of Preterm Birth and Its Modification by Folate Intake: The Japan Environment and Children’s Study |
| title_sort | association between interpregnancy interval and risk of preterm birth and its modification by folate intake the japan environment and children s study |
| topic | interpregnancy interval preterm birth folate folic acid prospective studies |
| url | https://www.jstage.jst.go.jp/article/jea/33/3/33_JE20210031/_pdf |
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