Downregulation of the NLRP3/Caspse-1 Pathway Ameliorates Ketamine-Induced Liver Injury and Inflammation in Developing Rats

Downregulation of the NLRP3/Caspse-1 Pathway Ameliorates Ketamine-Induced Liver Injury and Inflammation in Developing Rats

Ketamine is an anesthetic drug that is widely used in human and veterinary medicine. In the developmental stage, long-term exposure to ketamine may cause serious side effects. MCC950 and VX765 play protective roles in many disease models by regulating the NLRP3/Caspase-1 pathway. This study aims to...

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Bibliographic Details
Main Authors: Xinzhang Chen, Zhiheng Zhang, Meilun Shen, Xiangying Ma, Di Qiu, Siyao Li, Li Gao
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
ketamine
developing rats
livers
NLRP3/Caspase-1
Online Access:https://www.mdpi.com/1420-3049/27/9/2931

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