Gut microbiota metabolites, redox status, and the related regulatory effects of probiotics
Oxidative stress is a state of imbalance between oxidation and antioxidation. It is caused by excess levels of free radicals and leads to the damage of DNA, proteins, and lipids. The crucial role of gut microbiota in regulating oxidative stress has been widely demonstrated. Studies have suggested th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023086395 |
| _version_ | 1827615998981701632 |
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| author | Jinshan Zhao Fan Zhao Junmeng Yuan Huawei Liu Yang Wang |
| author_facet | Jinshan Zhao Fan Zhao Junmeng Yuan Huawei Liu Yang Wang |
| author_sort | Jinshan Zhao |
| collection | DOAJ |
| description | Oxidative stress is a state of imbalance between oxidation and antioxidation. It is caused by excess levels of free radicals and leads to the damage of DNA, proteins, and lipids. The crucial role of gut microbiota in regulating oxidative stress has been widely demonstrated. Studies have suggested that the redox regulatory effects of gut microbiota are related to gut microbiota metabolites, including fatty acids, lipopolysaccharides, tryptophan metabolites, trimethylamine-N-oxide and polyphenolic metabolites. In recent years, the potential benefits of probiotics have been gaining increasing scientific interest owing to their ability to modulate gut microbiota and oxidative stress. In this review, we summarise the adverse health effects of oxidative stress and discuss the role of the gut microbiota and its metabolites in redox regulation. Based on the influence of gut microbiota metabolites, the roles of probiotics in preventing oxidative stress are highlighted. |
| first_indexed | 2024-03-09T09:19:35Z |
| format | Article |
| id | doaj.art-425e534847ae41808376d9e18bbec518 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-09T09:19:35Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-425e534847ae41808376d9e18bbec5182023-12-02T07:02:15ZengElsevierHeliyon2405-84402023-11-01911e21431Gut microbiota metabolites, redox status, and the related regulatory effects of probioticsJinshan Zhao0Fan Zhao1Junmeng Yuan2Huawei Liu3Yang Wang4College of Animal Science and Technology, Qingdao Agricultural University, 266109, Qingdao, ChinaCollege of Animal Science and Technology, Qingdao Agricultural University, 266109, Qingdao, ChinaCollege of Animal Science and Technology, Qingdao Agricultural University, 266109, Qingdao, ChinaCollege of Animal Science and Technology, Qingdao Agricultural University, 266109, Qingdao, ChinaCorresponding author.; College of Animal Science and Technology, Qingdao Agricultural University, 266109, Qingdao, ChinaOxidative stress is a state of imbalance between oxidation and antioxidation. It is caused by excess levels of free radicals and leads to the damage of DNA, proteins, and lipids. The crucial role of gut microbiota in regulating oxidative stress has been widely demonstrated. Studies have suggested that the redox regulatory effects of gut microbiota are related to gut microbiota metabolites, including fatty acids, lipopolysaccharides, tryptophan metabolites, trimethylamine-N-oxide and polyphenolic metabolites. In recent years, the potential benefits of probiotics have been gaining increasing scientific interest owing to their ability to modulate gut microbiota and oxidative stress. In this review, we summarise the adverse health effects of oxidative stress and discuss the role of the gut microbiota and its metabolites in redox regulation. Based on the influence of gut microbiota metabolites, the roles of probiotics in preventing oxidative stress are highlighted.http://www.sciencedirect.com/science/article/pii/S2405844023086395Oxidative stressGut microbiotaGut microbiota metaboliteProbiotic |
| spellingShingle | Jinshan Zhao Fan Zhao Junmeng Yuan Huawei Liu Yang Wang Gut microbiota metabolites, redox status, and the related regulatory effects of probiotics Heliyon Oxidative stress Gut microbiota Gut microbiota metabolite Probiotic |
| title | Gut microbiota metabolites, redox status, and the related regulatory effects of probiotics |
| title_full | Gut microbiota metabolites, redox status, and the related regulatory effects of probiotics |
| title_fullStr | Gut microbiota metabolites, redox status, and the related regulatory effects of probiotics |
| title_full_unstemmed | Gut microbiota metabolites, redox status, and the related regulatory effects of probiotics |
| title_short | Gut microbiota metabolites, redox status, and the related regulatory effects of probiotics |
| title_sort | gut microbiota metabolites redox status and the related regulatory effects of probiotics |
| topic | Oxidative stress Gut microbiota Gut microbiota metabolite Probiotic |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023086395 |
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