Fabrication and In-Vivo Study of Micro-Colloidal <i>Zanthoxylum acanthopodium</i>-Loaded Bacterial Cellulose as a Burn Wound Dressing
Bacterial cellulose (BC) is a biopolymer commonly used for wound dressing due to its high biocompatible properties either in-vitro or in-vivo. The three-dimensional fiber structure of BC becomes an advantage because it provides a template for the impregnation of materials in order to improve BC’s pr...
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| Format: | Article |
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MDPI AG
2020-06-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/7/1436 |
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| author | Khatarina Meldawati Pasaribu Saharman Gea Syafruddin Ilyas Tamrin Tamrin Appealwan Altruistis Sarumaha Ardiansyah Sembiring Izabela Radecka |
| author_facet | Khatarina Meldawati Pasaribu Saharman Gea Syafruddin Ilyas Tamrin Tamrin Appealwan Altruistis Sarumaha Ardiansyah Sembiring Izabela Radecka |
| author_sort | Khatarina Meldawati Pasaribu |
| collection | DOAJ |
| description | Bacterial cellulose (BC) is a biopolymer commonly used for wound dressing due to its high biocompatible properties either in-vitro or in-vivo. The three-dimensional fiber structure of BC becomes an advantage because it provides a template for the impregnation of materials in order to improve BC’s properties as a wound dressing, since BC has not displayed any bioactivity properties. In this study, micro-colloidal <i>Zanthoxylum acanthopodium</i> (MZA) fruit was loaded into BC fibers via an in-situ method. <i>Z. acanthopodium</i> is known to have anti-inflammatory, antioxidant and antimicrobial activities that can support BC to accelerate the wound healing process. The FTIR, XRD and SEM analysis results showed that the loading process of MZA and the composite fabrication were successfully carried out. The TGA test also showed that the presence of MZA in BC fibers decreased T<sub>max</sub> composite from BC, from 357.8 to 334.5 °C for BC-MZA3. Other aspects, i.e., water content, porosity, hemocompatibility and histology studies, also showed that the composite could potentially be used as a wound dressing. |
| first_indexed | 2024-03-10T18:51:13Z |
| format | Article |
| id | doaj.art-425e7469d2b34b44b77ef0177e869083 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T18:51:13Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-425e7469d2b34b44b77ef0177e8690832023-11-20T05:07:36ZengMDPI AGPolymers2073-43602020-06-01127143610.3390/polym12071436Fabrication and In-Vivo Study of Micro-Colloidal <i>Zanthoxylum acanthopodium</i>-Loaded Bacterial Cellulose as a Burn Wound DressingKhatarina Meldawati Pasaribu0Saharman Gea1Syafruddin Ilyas2Tamrin Tamrin3Appealwan Altruistis Sarumaha4Ardiansyah Sembiring5Izabela Radecka6Postgraduate School, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jl. Bioteknologi No. 1, Medan 20155, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jl. Bioteknologi No. 1, Medan 20155, IndonesiaDepartment of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jl. Bioteknologi No. 1, Medan 20155, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jl. Bioteknologi No. 1, Medan 20155, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jl. Bioteknologi No. 1, Medan 20155, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jl. Bioteknologi No. 1, Medan 20155, IndonesiaWolverhampton School of Sciences, Faculty of Science and Engineering, University of Wolverhampton, Wulfruna Street, Wolverhampton WV1 1LY, UKBacterial cellulose (BC) is a biopolymer commonly used for wound dressing due to its high biocompatible properties either in-vitro or in-vivo. The three-dimensional fiber structure of BC becomes an advantage because it provides a template for the impregnation of materials in order to improve BC’s properties as a wound dressing, since BC has not displayed any bioactivity properties. In this study, micro-colloidal <i>Zanthoxylum acanthopodium</i> (MZA) fruit was loaded into BC fibers via an in-situ method. <i>Z. acanthopodium</i> is known to have anti-inflammatory, antioxidant and antimicrobial activities that can support BC to accelerate the wound healing process. The FTIR, XRD and SEM analysis results showed that the loading process of MZA and the composite fabrication were successfully carried out. The TGA test also showed that the presence of MZA in BC fibers decreased T<sub>max</sub> composite from BC, from 357.8 to 334.5 °C for BC-MZA3. Other aspects, i.e., water content, porosity, hemocompatibility and histology studies, also showed that the composite could potentially be used as a wound dressing.https://www.mdpi.com/2073-4360/12/7/1436bacterial celluloseMZABC-MZAcompositewound dressing |
| spellingShingle | Khatarina Meldawati Pasaribu Saharman Gea Syafruddin Ilyas Tamrin Tamrin Appealwan Altruistis Sarumaha Ardiansyah Sembiring Izabela Radecka Fabrication and In-Vivo Study of Micro-Colloidal <i>Zanthoxylum acanthopodium</i>-Loaded Bacterial Cellulose as a Burn Wound Dressing Polymers bacterial cellulose MZA BC-MZA composite wound dressing |
| title | Fabrication and In-Vivo Study of Micro-Colloidal <i>Zanthoxylum acanthopodium</i>-Loaded Bacterial Cellulose as a Burn Wound Dressing |
| title_full | Fabrication and In-Vivo Study of Micro-Colloidal <i>Zanthoxylum acanthopodium</i>-Loaded Bacterial Cellulose as a Burn Wound Dressing |
| title_fullStr | Fabrication and In-Vivo Study of Micro-Colloidal <i>Zanthoxylum acanthopodium</i>-Loaded Bacterial Cellulose as a Burn Wound Dressing |
| title_full_unstemmed | Fabrication and In-Vivo Study of Micro-Colloidal <i>Zanthoxylum acanthopodium</i>-Loaded Bacterial Cellulose as a Burn Wound Dressing |
| title_short | Fabrication and In-Vivo Study of Micro-Colloidal <i>Zanthoxylum acanthopodium</i>-Loaded Bacterial Cellulose as a Burn Wound Dressing |
| title_sort | fabrication and in vivo study of micro colloidal i zanthoxylum acanthopodium i loaded bacterial cellulose as a burn wound dressing |
| topic | bacterial cellulose MZA BC-MZA composite wound dressing |
| url | https://www.mdpi.com/2073-4360/12/7/1436 |
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