NOX Dependent ROS Generation and Cell Metabolism
Reactive oxygen species (ROS) represent a group of high reactive molecules with dualistic natures since they can induce cytotoxicity or regulate cellular physiology. Among the ROS, the superoxide anion radical (O2·−) is a key redox signaling molecule prominently generated by the NADPH oxidase (NOX)...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/3/2086 |
| _version_ | 1797624462728757248 |
|---|---|
| author | Tiziana Pecchillo Cimmino Rosario Ammendola Fabio Cattaneo Gabriella Esposito |
| author_facet | Tiziana Pecchillo Cimmino Rosario Ammendola Fabio Cattaneo Gabriella Esposito |
| author_sort | Tiziana Pecchillo Cimmino |
| collection | DOAJ |
| description | Reactive oxygen species (ROS) represent a group of high reactive molecules with dualistic natures since they can induce cytotoxicity or regulate cellular physiology. Among the ROS, the superoxide anion radical (O2·−) is a key redox signaling molecule prominently generated by the NADPH oxidase (NOX) enzyme family and by the mitochondrial electron transport chain. Notably, altered redox balance and deregulated redox signaling are recognized hallmarks of cancer and are involved in malignant progression and resistance to drugs treatment. Since oxidative stress and metabolism of cancer cells are strictly intertwined, in this review, we focus on the emerging roles of NOX enzymes as important modulators of metabolic reprogramming in cancer. The NOX family includes seven isoforms with different activation mechanisms, widely expressed in several tissues. In particular, we dissect the contribute of NOX1, NOX2, and NOX4 enzymes in the modulation of cellular metabolism and highlight their potential role as a new therapeutic target for tumor metabolism rewiring. |
| first_indexed | 2024-03-11T09:42:41Z |
| format | Article |
| id | doaj.art-425ff9d9b9004affb4b00402dacc54af |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:42:41Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-425ff9d9b9004affb4b00402dacc54af2023-11-16T16:52:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243208610.3390/ijms24032086NOX Dependent ROS Generation and Cell MetabolismTiziana Pecchillo Cimmino0Rosario Ammendola1Fabio Cattaneo2Gabriella Esposito3Department of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, School of Medicine, University of Naples Federico II, 80131 Naples, ItalyReactive oxygen species (ROS) represent a group of high reactive molecules with dualistic natures since they can induce cytotoxicity or regulate cellular physiology. Among the ROS, the superoxide anion radical (O2·−) is a key redox signaling molecule prominently generated by the NADPH oxidase (NOX) enzyme family and by the mitochondrial electron transport chain. Notably, altered redox balance and deregulated redox signaling are recognized hallmarks of cancer and are involved in malignant progression and resistance to drugs treatment. Since oxidative stress and metabolism of cancer cells are strictly intertwined, in this review, we focus on the emerging roles of NOX enzymes as important modulators of metabolic reprogramming in cancer. The NOX family includes seven isoforms with different activation mechanisms, widely expressed in several tissues. In particular, we dissect the contribute of NOX1, NOX2, and NOX4 enzymes in the modulation of cellular metabolism and highlight their potential role as a new therapeutic target for tumor metabolism rewiring.https://www.mdpi.com/1422-0067/24/3/2086NADPH oxidaseNOXreactive oxygen speciesROScell metabolismredox metabolism |
| spellingShingle | Tiziana Pecchillo Cimmino Rosario Ammendola Fabio Cattaneo Gabriella Esposito NOX Dependent ROS Generation and Cell Metabolism International Journal of Molecular Sciences NADPH oxidase NOX reactive oxygen species ROS cell metabolism redox metabolism |
| title | NOX Dependent ROS Generation and Cell Metabolism |
| title_full | NOX Dependent ROS Generation and Cell Metabolism |
| title_fullStr | NOX Dependent ROS Generation and Cell Metabolism |
| title_full_unstemmed | NOX Dependent ROS Generation and Cell Metabolism |
| title_short | NOX Dependent ROS Generation and Cell Metabolism |
| title_sort | nox dependent ros generation and cell metabolism |
| topic | NADPH oxidase NOX reactive oxygen species ROS cell metabolism redox metabolism |
| url | https://www.mdpi.com/1422-0067/24/3/2086 |
| work_keys_str_mv | AT tizianapecchillocimmino noxdependentrosgenerationandcellmetabolism AT rosarioammendola noxdependentrosgenerationandcellmetabolism AT fabiocattaneo noxdependentrosgenerationandcellmetabolism AT gabriellaesposito noxdependentrosgenerationandcellmetabolism |