THE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITY
Abstract. The aim of present study was to investigate the ratios of semen lymphocyte subpopulations in males with infertility. Twenty-six men (20 to 45 years old) suffering from different genital diseases (chronic prostatitis, idiopathic varicocoele, testicular atrophy) were enrolled into the study....
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/145 |
| _version_ | 1797198152769470464 |
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| author | A. V. Semenov N. Yu. Sotnikova |
| author_facet | A. V. Semenov N. Yu. Sotnikova |
| author_sort | A. V. Semenov |
| collection | DOAJ |
| description | Abstract. The aim of present study was to investigate the ratios of semen lymphocyte subpopulations in males with infertility. Twenty-six men (20 to 45 years old) suffering from different genital diseases (chronic prostatitis, idiopathic varicocoele, testicular atrophy) were enrolled into the study. Six healthy age-matched normozoospermic male volunteers with normal fertility comprised a control group. Lymphocyte phenotyping was performed by flow cytometric technique. The patients with pathospermia showed increased numbers of CD25+ lymphocytes (p < 0.05), and unchanged levels of CD95+ cells, thus leading to increased CD25+/CD95+ ratio. In the patients with normozoospermia, the value of this index was 0.94±0.18. Increase of this parameter to > 1.2, as well as its reduction to < 0.7 was associated with sterility. We suggest that suppressed apoptosis of activated lymphocytes in semen may be potentially dangerous to spermatogenesis, since both immune response and associated inflammatory reactions can cause nonspecific lesions of surrounding tissues, and induction of pathospermia. |
| first_indexed | 2024-03-08T05:51:28Z |
| format | Article |
| id | doaj.art-4260da167779447cbf6cd59ebe433d4e |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:55:19Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-4260da167779447cbf6cd59ebe433d4e2024-04-22T13:07:33ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0191919610.15789/1563-0625-2007-1-91-96142THE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITYA. V. Semenov0N. Yu. Sotnikova1ГОУ ВПО «Ивановская государственная медицинская академия Росздрава»ГОУ ВПО «Ивановская государственная медицинская академия Росздрава»Abstract. The aim of present study was to investigate the ratios of semen lymphocyte subpopulations in males with infertility. Twenty-six men (20 to 45 years old) suffering from different genital diseases (chronic prostatitis, idiopathic varicocoele, testicular atrophy) were enrolled into the study. Six healthy age-matched normozoospermic male volunteers with normal fertility comprised a control group. Lymphocyte phenotyping was performed by flow cytometric technique. The patients with pathospermia showed increased numbers of CD25+ lymphocytes (p < 0.05), and unchanged levels of CD95+ cells, thus leading to increased CD25+/CD95+ ratio. In the patients with normozoospermia, the value of this index was 0.94±0.18. Increase of this parameter to > 1.2, as well as its reduction to < 0.7 was associated with sterility. We suggest that suppressed apoptosis of activated lymphocytes in semen may be potentially dangerous to spermatogenesis, since both immune response and associated inflammatory reactions can cause nonspecific lesions of surrounding tissues, and induction of pathospermia.https://www.mimmun.ru/mimmun/article/view/145lymphocytes activationlymphocytes apoptosismales with infertilitysemenflow cytometry |
| spellingShingle | A. V. Semenov N. Yu. Sotnikova THE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITY Медицинская иммунология lymphocytes activation lymphocytes apoptosis males with infertility semen flow cytometry |
| title | THE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITY |
| title_full | THE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITY |
| title_fullStr | THE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITY |
| title_full_unstemmed | THE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITY |
| title_short | THE CHANGES IN SEMEN LYMPHOCYTE SUBPOPULATION’S RATIO IN MEN INFERTILITY |
| title_sort | changes in semen lymphocyte subpopulation s ratio in men infertility |
| topic | lymphocytes activation lymphocytes apoptosis males with infertility semen flow cytometry |
| url | https://www.mimmun.ru/mimmun/article/view/145 |
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