Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma—An Even Broader Tumor Entity?
Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a recently defined tumor subtype with apparent favorable clinical outcome despite aggressive histomorphology. However, in recent years, additional numbers of cases, with more variable features and at locations outside t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/9/1861 |
| _version_ | 1827681022850891776 |
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| author | Mark Zupancic Anders Näsman |
| author_facet | Mark Zupancic Anders Näsman |
| author_sort | Mark Zupancic |
| collection | DOAJ |
| description | Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a recently defined tumor subtype with apparent favorable clinical outcome despite aggressive histomorphology. However, in recent years, additional numbers of cases, with more variable features and at locations outside the sinonasal region, have complicated the definition of HMSC. Here, we have performed a systematic review of all cases described so far in order to accumulate more knowledge. We identified 127 articles published between 2013 and 2021, of which 21 presented unique cases. In total, 79 unique patient cases were identified and their clinical and micromorphological nature are herein summarized. In our opinion, better clinical follow-up data and a more detailed tumor characterization are preferably needed before HMSC can finally be justified as its own tumor entity. |
| first_indexed | 2024-03-10T07:07:32Z |
| format | Article |
| id | doaj.art-4261003fc0d043919ea5ef5282adc6cf |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T07:07:32Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-4261003fc0d043919ea5ef5282adc6cf2023-11-22T15:39:06ZengMDPI AGViruses1999-49152021-09-01139186110.3390/v13091861Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma—An Even Broader Tumor Entity?Mark Zupancic0Anders Näsman1Department of Oncology-Pathology, Karolinska Institutet, Bioclinicum J6:20, Karolinska University Hospital, 17164 Stockholm, SwedenDepartment of Oncology-Pathology, Karolinska Institutet, Bioclinicum J6:20, Karolinska University Hospital, 17164 Stockholm, SwedenHuman papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC) is a recently defined tumor subtype with apparent favorable clinical outcome despite aggressive histomorphology. However, in recent years, additional numbers of cases, with more variable features and at locations outside the sinonasal region, have complicated the definition of HMSC. Here, we have performed a systematic review of all cases described so far in order to accumulate more knowledge. We identified 127 articles published between 2013 and 2021, of which 21 presented unique cases. In total, 79 unique patient cases were identified and their clinical and micromorphological nature are herein summarized. In our opinion, better clinical follow-up data and a more detailed tumor characterization are preferably needed before HMSC can finally be justified as its own tumor entity.https://www.mdpi.com/1999-4915/13/9/1861human papillomavirushuman papillomavirus-related multiphenotypic sinonasal carcinomahead and neck cancerbasaloid squamous cell carcinoma |
| spellingShingle | Mark Zupancic Anders Näsman Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma—An Even Broader Tumor Entity? Viruses human papillomavirus human papillomavirus-related multiphenotypic sinonasal carcinoma head and neck cancer basaloid squamous cell carcinoma |
| title | Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma—An Even Broader Tumor Entity? |
| title_full | Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma—An Even Broader Tumor Entity? |
| title_fullStr | Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma—An Even Broader Tumor Entity? |
| title_full_unstemmed | Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma—An Even Broader Tumor Entity? |
| title_short | Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma—An Even Broader Tumor Entity? |
| title_sort | human papillomavirus related multiphenotypic sinonasal carcinoma an even broader tumor entity |
| topic | human papillomavirus human papillomavirus-related multiphenotypic sinonasal carcinoma head and neck cancer basaloid squamous cell carcinoma |
| url | https://www.mdpi.com/1999-4915/13/9/1861 |
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