Effects of quercetin and extracts from Phyllanthus emblica, Morus alba, and Ginkgo biloba on platelet recovery in a rat model of chemotherapy-induced thrombocytopenia
Background: Chemotherapy-induced thrombocytopenia (CIT) is a major reason for chemotherapy delays, dose reduction, or even treatment discontinuation, which may impact oncologic outcomes. We investigated the effects of quercetin and extracts of Phyllanthus emblica fruit (PEE), Morus alba leaf (MAE),...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024010442 |
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| author | Kriangkrai Chawansuntati Sayamon Hongjaisee Kittichai Sirita Kornkamon Kingkaew Kritsadee Rattanathammethee Benjawan Kumrapich Sakaewan Ounjaijean Aphisek Kongkaew Nongkran Lumjuan |
| author_facet | Kriangkrai Chawansuntati Sayamon Hongjaisee Kittichai Sirita Kornkamon Kingkaew Kritsadee Rattanathammethee Benjawan Kumrapich Sakaewan Ounjaijean Aphisek Kongkaew Nongkran Lumjuan |
| author_sort | Kriangkrai Chawansuntati |
| collection | DOAJ |
| description | Background: Chemotherapy-induced thrombocytopenia (CIT) is a major reason for chemotherapy delays, dose reduction, or even treatment discontinuation, which may impact oncologic outcomes. We investigated the effects of quercetin and extracts of Phyllanthus emblica fruit (PEE), Morus alba leaf (MAE), and Ginkgo biloba leaf (GBE) on platelet recovery in a rat model of chemotherapy-induced thrombocytopenia. Methods: The total phenolic content (TPC), total flavonoid content (TFC), quercetin content, and antioxidant activities of all the extracts were determined. Sixty male Sprague Dawley rats were categorized into healthy controls and CIT groups. The CIT groups was administered a cyclophosphamide solution, while the control group received a saline solution. Each group was then subdivided into five subgroups of six animals which were administered with PEE, MAE, GBE, quercetin, or a vehicle for 15 days. Results: The highest quercetin content was found in PEE, followed by MAE and GBE, which correlated with their antioxidant properties. Administration of these extracts and quercetin did not significantly change the platelet counts in healthy rats. Thrombocytopenic rats treated with PEE, MAE, and GBE also were not associated with significant changes in platelet counts. However, more rapid platelet count recovery was observed in all groups receiving extracts. On day 11, platelet counts in the PEE, MAE, and GBE groups returned to near baseline levels with a mean of 4.29 %, −40.77 %, and −14.24 %, respectively, compared to −71 % in the CIT group. In thrombocytopenic rats treated with quercetin, there was a significant increase in platelet counts on days 9 and 11, with a mean decrease of 5.41 % from baseline on day 11. Conclusion: Quercetin improved platelet recovery in the animal model of CIT. This finding merits for further investigation to better elucidate the health benefits of quercetin and quercetin-rich plants and potential pharmacokinetics underpinning their activity in thrombocytopenia. |
| first_indexed | 2024-03-08T06:53:49Z |
| format | Article |
| id | doaj.art-4261034c796c4dc796a468376d4b0c35 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T06:53:49Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-4261034c796c4dc796a468376d4b0c352024-02-03T06:38:49ZengElsevierHeliyon2405-84402024-01-01102e25013Effects of quercetin and extracts from Phyllanthus emblica, Morus alba, and Ginkgo biloba on platelet recovery in a rat model of chemotherapy-induced thrombocytopeniaKriangkrai Chawansuntati0Sayamon Hongjaisee1Kittichai Sirita2Kornkamon Kingkaew3Kritsadee Rattanathammethee4Benjawan Kumrapich5Sakaewan Ounjaijean6Aphisek Kongkaew7Nongkran Lumjuan8Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, 50200, ThailandResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai, 50200, ThailandResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai, 50200, ThailandResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai, 50200, ThailandResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai, 50200, ThailandResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai, 50200, ThailandResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai, 50200, ThailandResearch Administration Section, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, ThailandResearch Institute for Health Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand; Corresponding author. Research Institute for Health Sciences, Chiang Mai University, 110 Intavaroros Road, Sriphum, Muang, Chiang Mai, 50200, Thailand.Background: Chemotherapy-induced thrombocytopenia (CIT) is a major reason for chemotherapy delays, dose reduction, or even treatment discontinuation, which may impact oncologic outcomes. We investigated the effects of quercetin and extracts of Phyllanthus emblica fruit (PEE), Morus alba leaf (MAE), and Ginkgo biloba leaf (GBE) on platelet recovery in a rat model of chemotherapy-induced thrombocytopenia. Methods: The total phenolic content (TPC), total flavonoid content (TFC), quercetin content, and antioxidant activities of all the extracts were determined. Sixty male Sprague Dawley rats were categorized into healthy controls and CIT groups. The CIT groups was administered a cyclophosphamide solution, while the control group received a saline solution. Each group was then subdivided into five subgroups of six animals which were administered with PEE, MAE, GBE, quercetin, or a vehicle for 15 days. Results: The highest quercetin content was found in PEE, followed by MAE and GBE, which correlated with their antioxidant properties. Administration of these extracts and quercetin did not significantly change the platelet counts in healthy rats. Thrombocytopenic rats treated with PEE, MAE, and GBE also were not associated with significant changes in platelet counts. However, more rapid platelet count recovery was observed in all groups receiving extracts. On day 11, platelet counts in the PEE, MAE, and GBE groups returned to near baseline levels with a mean of 4.29 %, −40.77 %, and −14.24 %, respectively, compared to −71 % in the CIT group. In thrombocytopenic rats treated with quercetin, there was a significant increase in platelet counts on days 9 and 11, with a mean decrease of 5.41 % from baseline on day 11. Conclusion: Quercetin improved platelet recovery in the animal model of CIT. This finding merits for further investigation to better elucidate the health benefits of quercetin and quercetin-rich plants and potential pharmacokinetics underpinning their activity in thrombocytopenia.http://www.sciencedirect.com/science/article/pii/S2405844024010442Ginkgo bilobaMorus albaPhyllanthus emblicaPlateletQuercetinThrombocytopenia |
| spellingShingle | Kriangkrai Chawansuntati Sayamon Hongjaisee Kittichai Sirita Kornkamon Kingkaew Kritsadee Rattanathammethee Benjawan Kumrapich Sakaewan Ounjaijean Aphisek Kongkaew Nongkran Lumjuan Effects of quercetin and extracts from Phyllanthus emblica, Morus alba, and Ginkgo biloba on platelet recovery in a rat model of chemotherapy-induced thrombocytopenia Heliyon Ginkgo biloba Morus alba Phyllanthus emblica Platelet Quercetin Thrombocytopenia |
| title | Effects of quercetin and extracts from Phyllanthus emblica, Morus alba, and Ginkgo biloba on platelet recovery in a rat model of chemotherapy-induced thrombocytopenia |
| title_full | Effects of quercetin and extracts from Phyllanthus emblica, Morus alba, and Ginkgo biloba on platelet recovery in a rat model of chemotherapy-induced thrombocytopenia |
| title_fullStr | Effects of quercetin and extracts from Phyllanthus emblica, Morus alba, and Ginkgo biloba on platelet recovery in a rat model of chemotherapy-induced thrombocytopenia |
| title_full_unstemmed | Effects of quercetin and extracts from Phyllanthus emblica, Morus alba, and Ginkgo biloba on platelet recovery in a rat model of chemotherapy-induced thrombocytopenia |
| title_short | Effects of quercetin and extracts from Phyllanthus emblica, Morus alba, and Ginkgo biloba on platelet recovery in a rat model of chemotherapy-induced thrombocytopenia |
| title_sort | effects of quercetin and extracts from phyllanthus emblica morus alba and ginkgo biloba on platelet recovery in a rat model of chemotherapy induced thrombocytopenia |
| topic | Ginkgo biloba Morus alba Phyllanthus emblica Platelet Quercetin Thrombocytopenia |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024010442 |
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