Adherence to Mediterranean diet and its association with multiple colonic polyps of unknown origin: a case-control study
IntroductionMultiple colonic polyps do not have a genetic origin in most patients, and the cause of this phenotype remains elusive. Environmental factors, such as diet, could be related to this phenotype. Our aim was to investigate the relationship between the adherence to Mediterranean diet and mul...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1186808/full |
| _version_ | 1797797723901001728 |
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| author | Gabriela Bujanda-Miguel Alejandro Martínez-Roca Anabel García-Heredia David Guill-Berbegal Enrique Roche Enrique Roche Enrique Roche Rodrigo Jover Rodrigo Jover |
| author_facet | Gabriela Bujanda-Miguel Alejandro Martínez-Roca Anabel García-Heredia David Guill-Berbegal Enrique Roche Enrique Roche Enrique Roche Rodrigo Jover Rodrigo Jover |
| author_sort | Gabriela Bujanda-Miguel |
| collection | DOAJ |
| description | IntroductionMultiple colonic polyps do not have a genetic origin in most patients, and the cause of this phenotype remains elusive. Environmental factors, such as diet, could be related to this phenotype. Our aim was to investigate the relationship between the adherence to Mediterranean diet and multiple colonic polyps of unknown origin.MethodsA case-control pilot study was carried out with a sample of 38 individuals, including 23 cases with more than 10 adenomatous or serrated polyps from the national multicenter project EPIPOLIP and 15 healthy controls with normal colonoscopy. A validated Spanish version of the MEDAS questionnaire was administered to cases and controls.ResultsAdherence to Mediterranean diet was higher in controls than in patients with multiple colonic polyps (MEDAS score: 8.6 ± 1.4 vs. 7.0 ± 1.6; p = 0.01). Optimal overall adherence to the Mediterranean diet pattern was significantly higher among the controls than among cases (MEDAS score >9: 46% vs. 13%; OR 0.17; 95% CI 0.03–0.83). Non-optimal adherence to the Mediterranean diet acts as a risk factor for developing colorectal cancer derived from colorectal polyps.ConclusionOur results suggest that environmental factors play a role in the pathogenesis of this phenotype. |
| first_indexed | 2024-03-13T03:52:42Z |
| format | Article |
| id | doaj.art-4261693d00cb48e5bf20e4671865e80d |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-13T03:52:42Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-4261693d00cb48e5bf20e4671865e80d2023-06-22T09:25:17ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-06-011010.3389/fnut.2023.11868081186808Adherence to Mediterranean diet and its association with multiple colonic polyps of unknown origin: a case-control studyGabriela Bujanda-Miguel0Alejandro Martínez-Roca1Anabel García-Heredia2David Guill-Berbegal3Enrique Roche4Enrique Roche5Enrique Roche6Rodrigo Jover7Rodrigo Jover8Servicio de Medicina Digestiva, Hospital General Universitario Dr. Balmis, Instituto de Investigación Biomédica ISABIAL, Alicante, SpainServicio de Medicina Digestiva, Hospital General Universitario Dr. Balmis, Instituto de Investigación Biomédica ISABIAL, Alicante, SpainServicio de Medicina Digestiva, Hospital General Universitario Dr. Balmis, Instituto de Investigación Biomédica ISABIAL, Alicante, SpainServicio de Medicina Digestiva, Hospital General Universitario Dr. Balmis, Instituto de Investigación Biomédica ISABIAL, Alicante, SpainServicio de Medicina Digestiva, Hospital General Universitario Dr. Balmis, Instituto de Investigación Biomédica ISABIAL, Alicante, SpainDepartment of Applied Biology-Nutrition, Institute of Bioengineering, University Miguel Hernández, Elche, SpainCIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, SpainServicio de Medicina Digestiva, Hospital General Universitario Dr. Balmis, Instituto de Investigación Biomédica ISABIAL, Alicante, SpainDepartamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, SpainIntroductionMultiple colonic polyps do not have a genetic origin in most patients, and the cause of this phenotype remains elusive. Environmental factors, such as diet, could be related to this phenotype. Our aim was to investigate the relationship between the adherence to Mediterranean diet and multiple colonic polyps of unknown origin.MethodsA case-control pilot study was carried out with a sample of 38 individuals, including 23 cases with more than 10 adenomatous or serrated polyps from the national multicenter project EPIPOLIP and 15 healthy controls with normal colonoscopy. A validated Spanish version of the MEDAS questionnaire was administered to cases and controls.ResultsAdherence to Mediterranean diet was higher in controls than in patients with multiple colonic polyps (MEDAS score: 8.6 ± 1.4 vs. 7.0 ± 1.6; p = 0.01). Optimal overall adherence to the Mediterranean diet pattern was significantly higher among the controls than among cases (MEDAS score >9: 46% vs. 13%; OR 0.17; 95% CI 0.03–0.83). Non-optimal adherence to the Mediterranean diet acts as a risk factor for developing colorectal cancer derived from colorectal polyps.ConclusionOur results suggest that environmental factors play a role in the pathogenesis of this phenotype.https://www.frontiersin.org/articles/10.3389/fnut.2023.1186808/fulladenomatous polypscolorectal cancercolorectal polypsdietserrated polyps |
| spellingShingle | Gabriela Bujanda-Miguel Alejandro Martínez-Roca Anabel García-Heredia David Guill-Berbegal Enrique Roche Enrique Roche Enrique Roche Rodrigo Jover Rodrigo Jover Adherence to Mediterranean diet and its association with multiple colonic polyps of unknown origin: a case-control study Frontiers in Nutrition adenomatous polyps colorectal cancer colorectal polyps diet serrated polyps |
| title | Adherence to Mediterranean diet and its association with multiple colonic polyps of unknown origin: a case-control study |
| title_full | Adherence to Mediterranean diet and its association with multiple colonic polyps of unknown origin: a case-control study |
| title_fullStr | Adherence to Mediterranean diet and its association with multiple colonic polyps of unknown origin: a case-control study |
| title_full_unstemmed | Adherence to Mediterranean diet and its association with multiple colonic polyps of unknown origin: a case-control study |
| title_short | Adherence to Mediterranean diet and its association with multiple colonic polyps of unknown origin: a case-control study |
| title_sort | adherence to mediterranean diet and its association with multiple colonic polyps of unknown origin a case control study |
| topic | adenomatous polyps colorectal cancer colorectal polyps diet serrated polyps |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1186808/full |
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