Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases
Traditional Chinese Medicine (TCM) with its focus on herbal use became popular worldwide. Treatment was perceived as safe, with neglect of rare adverse reactions including liver injury. To compile worldwide cases of liver injury by herbal TCM, we undertook a selective literature search in the PubMed...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-01-01
|
| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119307963 |
| _version_ | 1819012143154987008 |
|---|---|
| author | Rolf Teschke Li Zhang Hongzhu Long Alexander Schwarzenboeck Wolfgang Schmidt-Taenzer Alexander Genthner Albrecht Wolff Christian Frenzel Johannes Schulze Axel Eickhoff |
| author_facet | Rolf Teschke Li Zhang Hongzhu Long Alexander Schwarzenboeck Wolfgang Schmidt-Taenzer Alexander Genthner Albrecht Wolff Christian Frenzel Johannes Schulze Axel Eickhoff |
| author_sort | Rolf Teschke |
| collection | DOAJ |
| description | Traditional Chinese Medicine (TCM) with its focus on herbal use became popular worldwide. Treatment was perceived as safe, with neglect of rare adverse reactions including liver injury. To compile worldwide cases of liver injury by herbal TCM, we undertook a selective literature search in the PubMed database and searched for the items Traditional Chinese Medicine, TCM, Traditional Asian Medicine, and Traditional Oriental Medicine, also combined with the terms herbal hepatotoxicity or herb induced liver injury. The search focused primarily on English-language case reports, case series, and clinical reviews. We identified reported hepatotoxicity cases in 77 relevant publications with 57 different herbs and herbal mixtures of TCM, which were further analyzed for causality by the Council for International Organizations of Medical Sciences (CIOMS) scale, positive reexposure test results, or both. Causality was established for 28/57 different herbs or herbal mixtures, Bai Xian Pi, Bo He, Ci Wu Jia, Chuan Lian Zi, Da Huang, Gan Cao, Ge Gen, Ho Shou Wu, Huang Qin, Hwang Geun Cho, Ji Gu Cao, Ji Xue Cao, Jin Bu Huan, Jue Ming Zi, Jiguja, Kudzu, Ling Yang Qing Fei Keli, Lu Cha, Rhen Shen, Ma Huang, Shou Wu Pian, Shan Chi, Shen Min, Syo Saiko To, Xiao Chai Hu Tang, Yin Chen Hao, Zexie, and Zhen Chu Cao. In conclusion, this compilation of liver injury cases establishes causality for 28/57 different TCM herbs and herbal mixtures, aiding diagnosis for physicians who care for patients with liver disease possibly related to herbal TCM. |
| first_indexed | 2024-12-21T01:39:22Z |
| format | Article |
| id | doaj.art-426221242471469ebfac5ccd59986efe |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-12-21T01:39:22Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-426221242471469ebfac5ccd59986efe2022-12-21T19:20:10ZengElsevierAnnals of Hepatology1665-26812015-01-01141719Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported casesRolf Teschke0Li Zhang1Hongzhu Long2Alexander Schwarzenboeck3Wolfgang Schmidt-Taenzer4Alexander Genthner5Albrecht Wolff6Christian Frenzel7Johannes Schulze8Axel Eickhoff9Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt/ Main, Germany; Correspondence and reprint request:Center for Drug Reevaluation, China Food and Drug Administration, Beijing, ChinaDepartment of Internal Medicine, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt/ Main, GermanyDepartment of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt/ Main, GermanyDepartment of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt/ Main, GermanyDepartment of Internal Medicine II, Division of Gastroenterology, Hepatology and Infectious Diseases, Friedrich Schiller University Jena, GermanyDepartment of Medicine I, University Medical Center Hamburg Eppendorf, GermanyInstitute of Industrial, Environmental and Social Medicine, Medical Faculty of the Goethe University Frankfurt/Main, GermanyDepartment of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt/ Main, GermanyTraditional Chinese Medicine (TCM) with its focus on herbal use became popular worldwide. Treatment was perceived as safe, with neglect of rare adverse reactions including liver injury. To compile worldwide cases of liver injury by herbal TCM, we undertook a selective literature search in the PubMed database and searched for the items Traditional Chinese Medicine, TCM, Traditional Asian Medicine, and Traditional Oriental Medicine, also combined with the terms herbal hepatotoxicity or herb induced liver injury. The search focused primarily on English-language case reports, case series, and clinical reviews. We identified reported hepatotoxicity cases in 77 relevant publications with 57 different herbs and herbal mixtures of TCM, which were further analyzed for causality by the Council for International Organizations of Medical Sciences (CIOMS) scale, positive reexposure test results, or both. Causality was established for 28/57 different herbs or herbal mixtures, Bai Xian Pi, Bo He, Ci Wu Jia, Chuan Lian Zi, Da Huang, Gan Cao, Ge Gen, Ho Shou Wu, Huang Qin, Hwang Geun Cho, Ji Gu Cao, Ji Xue Cao, Jin Bu Huan, Jue Ming Zi, Jiguja, Kudzu, Ling Yang Qing Fei Keli, Lu Cha, Rhen Shen, Ma Huang, Shou Wu Pian, Shan Chi, Shen Min, Syo Saiko To, Xiao Chai Hu Tang, Yin Chen Hao, Zexie, and Zhen Chu Cao. In conclusion, this compilation of liver injury cases establishes causality for 28/57 different TCM herbs and herbal mixtures, aiding diagnosis for physicians who care for patients with liver disease possibly related to herbal TCM.http://www.sciencedirect.com/science/article/pii/S1665268119307963Herb induced liver injuryCouncil for International Organizations of Medical SciencesHerbsCausality assessmentRe-exposure |
| spellingShingle | Rolf Teschke Li Zhang Hongzhu Long Alexander Schwarzenboeck Wolfgang Schmidt-Taenzer Alexander Genthner Albrecht Wolff Christian Frenzel Johannes Schulze Axel Eickhoff Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases Annals of Hepatology Herb induced liver injury Council for International Organizations of Medical Sciences Herbs Causality assessment Re-exposure |
| title | Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases |
| title_full | Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases |
| title_fullStr | Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases |
| title_full_unstemmed | Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases |
| title_short | Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases |
| title_sort | traditional chinese medicine and herbal hepatotoxicity a tabular compilation of reported cases |
| topic | Herb induced liver injury Council for International Organizations of Medical Sciences Herbs Causality assessment Re-exposure |
| url | http://www.sciencedirect.com/science/article/pii/S1665268119307963 |
| work_keys_str_mv | AT rolfteschke traditionalchinesemedicineandherbalhepatotoxicityatabularcompilationofreportedcases AT lizhang traditionalchinesemedicineandherbalhepatotoxicityatabularcompilationofreportedcases AT hongzhulong traditionalchinesemedicineandherbalhepatotoxicityatabularcompilationofreportedcases AT alexanderschwarzenboeck traditionalchinesemedicineandherbalhepatotoxicityatabularcompilationofreportedcases AT wolfgangschmidttaenzer traditionalchinesemedicineandherbalhepatotoxicityatabularcompilationofreportedcases AT alexandergenthner traditionalchinesemedicineandherbalhepatotoxicityatabularcompilationofreportedcases AT albrechtwolff traditionalchinesemedicineandherbalhepatotoxicityatabularcompilationofreportedcases AT christianfrenzel traditionalchinesemedicineandherbalhepatotoxicityatabularcompilationofreportedcases AT johannesschulze traditionalchinesemedicineandherbalhepatotoxicityatabularcompilationofreportedcases AT axeleickhoff traditionalchinesemedicineandherbalhepatotoxicityatabularcompilationofreportedcases |