Effects of a Natural Prolyl Oligopeptidase Inhibitor, Rosmarinic Acid, on Lipopolysaccharide-Induced Acute Lung Injury in Mice

Effects of a Natural Prolyl Oligopeptidase Inhibitor, Rosmarinic Acid, on Lipopolysaccharide-Induced Acute Lung Injury in Mice

Rosmarinic acid (RA), a polyphenolic phytochemical, is a natural prolyl oligopeptidase inhibitor. In the present study, we found that RA exerted potent anti-inflammatory effects in in vivo models of acute lung injury (ALI) induced by lipopolysaccharide (LPS). Mice were pretreated with RA one hour be...

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Bibliographic Details
Main Authors: Miaomiao Wei, Qingjun Cao, Mingfeng Guan, Xianxing Xie, Jiakang He, Xuming Deng, Lanxiang Jiang, Xiao Chu, Xinxin Ci
Format: Article
Language:English
Published: MDPI AG 2012-03-01
Series:Molecules
Subjects:
rosmarinic acid
LPS
SOD
MAPK
ALI
Online Access:http://www.mdpi.com/1420-3049/17/3/3586/

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