Vitamin B Mitigates Thoracic Aortic Dilation in Marfan Syndrome Mice by Restoring the Canonical TGF-β Pathway

Vitamin B Mitigates Thoracic Aortic Dilation in Marfan Syndrome Mice by Restoring the Canonical TGF-β Pathway

Thoracic aortic aneurysm (TAA) formation is a multifactorial process that results in diverse clinical manifestations and drug responses. Identifying the critical factors and their functions in Marfan syndrome (MFS) pathogenesis is important for exploring personalized medicine for MFS. Methylenetetra...

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Bibliographic Details
Main Authors: Tzu-Heng Huang, Hsiao-Huang Chang, Yu-Ru Guo, Wei-Chiao Chang, Yi-Fan Chen
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
Marfan syndrome
fibrillin 1 mutation
thoracic aortic aneurysm (TAA)
thoracic aortic dissection (TAD)
vitamin B
folate-methionine cycle
Online Access:https://www.mdpi.com/1422-0067/22/21/11737

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