A macroprolactinemia--da determinação laboratorial ao seu significado clínico.
Since prolactin (PRL) (a hormone produced by the anterior pituitary) was first identificated, the existence of hyperprolactinemic syndrome has been recognized. Main symptoms are galactorrhea, oligomenorrhea, amenorrhea and infertility in women and decreased libido and impotence in men. Macroprolacti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ordem dos Médicos
2011-12-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1575 |
| _version_ | 1798021002731454464 |
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| author | Catarina Matos Marias Lopes Pereira João Tiago Guimarães |
| author_facet | Catarina Matos Marias Lopes Pereira João Tiago Guimarães |
| author_sort | Catarina Matos |
| collection | DOAJ |
| description | Since prolactin (PRL) (a hormone produced by the anterior pituitary) was first identificated, the existence of hyperprolactinemic syndrome has been recognized. Main symptoms are galactorrhea, oligomenorrhea, amenorrhea and infertility in women and decreased libido and impotence in men. Macroprolactinemia reflects the predominance of circulating forms with reduced bioactivity not associated with typical clinical manifestations of hyperprolactinemia. It is identified by immunoassays commonly used in clinical practice, resulting in hyperprolactinemia. Polyetilenoglycol (PEG) is the most used method that removes PRL from serum. It is likely that the phenomenon of macroprolactinemia is consistently underestimated and unrecognized. Manufacturers of immunoassays for PRL have been slow to incorporate in the literature, validated protocols, and data related to the interference of PEG. From a clinical and biochemical point of view and, the main concern should be to avoid unnecessary investigation and treatment. |
| first_indexed | 2024-04-11T17:06:54Z |
| format | Article |
| id | doaj.art-426af41c74304d6a8d68f7d8727a7fea |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-11T17:06:54Z |
| publishDate | 2011-12-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-426af41c74304d6a8d68f7d8727a7fea2022-12-22T04:13:01ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07582011-12-012410.20344/amp.1575A macroprolactinemia--da determinação laboratorial ao seu significado clínico.Catarina Matos0Marias Lopes PereiraJoão Tiago GuimarãesInterna de Endocrinologia, Serviço de Endocrinologia, Hospital de Braga, Braga, Portugal.Since prolactin (PRL) (a hormone produced by the anterior pituitary) was first identificated, the existence of hyperprolactinemic syndrome has been recognized. Main symptoms are galactorrhea, oligomenorrhea, amenorrhea and infertility in women and decreased libido and impotence in men. Macroprolactinemia reflects the predominance of circulating forms with reduced bioactivity not associated with typical clinical manifestations of hyperprolactinemia. It is identified by immunoassays commonly used in clinical practice, resulting in hyperprolactinemia. Polyetilenoglycol (PEG) is the most used method that removes PRL from serum. It is likely that the phenomenon of macroprolactinemia is consistently underestimated and unrecognized. Manufacturers of immunoassays for PRL have been slow to incorporate in the literature, validated protocols, and data related to the interference of PEG. From a clinical and biochemical point of view and, the main concern should be to avoid unnecessary investigation and treatment.https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1575 |
| spellingShingle | Catarina Matos Marias Lopes Pereira João Tiago Guimarães A macroprolactinemia--da determinação laboratorial ao seu significado clínico. Acta Médica Portuguesa |
| title | A macroprolactinemia--da determinação laboratorial ao seu significado clínico. |
| title_full | A macroprolactinemia--da determinação laboratorial ao seu significado clínico. |
| title_fullStr | A macroprolactinemia--da determinação laboratorial ao seu significado clínico. |
| title_full_unstemmed | A macroprolactinemia--da determinação laboratorial ao seu significado clínico. |
| title_short | A macroprolactinemia--da determinação laboratorial ao seu significado clínico. |
| title_sort | macroprolactinemia da determinacao laboratorial ao seu significado clinico |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1575 |
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