Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma
Melanoma is the most aggressive malignant skin tumor and arises from melanocytes. The resistance of melanoma cells to various treatments results in rapid tumor growth and high mortality. As a local therapeutic modality, photodynamic therapy has been successfully applied for clinical treatment of ski...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00597/full |
| _version_ | 1818921881610223616 |
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| author | Xin-Ying Li Liu-Chang Tan Li-Wen Dong Wan-Qi Zhang Xiao-Xiao Shen Xiao Lu Hong Zheng Yuan-Gang Lu |
| author_facet | Xin-Ying Li Liu-Chang Tan Li-Wen Dong Wan-Qi Zhang Xiao-Xiao Shen Xiao Lu Hong Zheng Yuan-Gang Lu |
| author_sort | Xin-Ying Li |
| collection | DOAJ |
| description | Melanoma is the most aggressive malignant skin tumor and arises from melanocytes. The resistance of melanoma cells to various treatments results in rapid tumor growth and high mortality. As a local therapeutic modality, photodynamic therapy has been successfully applied for clinical treatment of skin diseases. Photodynamic therapy is a relatively new treatment method for various types of malignant tumors in humans and, compared to conventional treatment methods, has fewer side effects, and is more accurate and non-invasive. Although several in vivo and in vitro studies have shown encouraging results regarding the potential benefits of photodynamic therapy as an adjuvant treatment for melanoma, its clinical application remains limited owing to its relative inefficiency. This review article discusses the use of photodynamic therapy in melanoma treatment as well as the latest progress made in deciphering the mechanism of tolerance. Lastly, potential targets are identified that may improve photodynamic therapy against melanoma cells. |
| first_indexed | 2024-12-20T01:44:42Z |
| format | Article |
| id | doaj.art-426ca34a242c4f2f9ba3d146d17649f9 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-20T01:44:42Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-426ca34a242c4f2f9ba3d146d17649f92022-12-21T19:57:47ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-05-011010.3389/fonc.2020.00597523324Susceptibility and Resistance Mechanisms During Photodynamic Therapy of MelanomaXin-Ying Li0Liu-Chang Tan1Li-Wen Dong2Wan-Qi Zhang3Xiao-Xiao Shen4Xiao Lu5Hong Zheng6Yuan-Gang Lu7Department of Plastic Surgery, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Plastic Surgery, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Plastic Surgery, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Plastic Surgery, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Plastic Surgery, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Thoracic Surgery, Xinqiao Hospital, Army Medical University, Chongqing, ChinaDepartment of Thoracic Surgery, Xinqiao Hospital, Army Medical University, Chongqing, ChinaDepartment of Plastic Surgery, Daping Hospital, Army Medical University, Chongqing, ChinaMelanoma is the most aggressive malignant skin tumor and arises from melanocytes. The resistance of melanoma cells to various treatments results in rapid tumor growth and high mortality. As a local therapeutic modality, photodynamic therapy has been successfully applied for clinical treatment of skin diseases. Photodynamic therapy is a relatively new treatment method for various types of malignant tumors in humans and, compared to conventional treatment methods, has fewer side effects, and is more accurate and non-invasive. Although several in vivo and in vitro studies have shown encouraging results regarding the potential benefits of photodynamic therapy as an adjuvant treatment for melanoma, its clinical application remains limited owing to its relative inefficiency. This review article discusses the use of photodynamic therapy in melanoma treatment as well as the latest progress made in deciphering the mechanism of tolerance. Lastly, potential targets are identified that may improve photodynamic therapy against melanoma cells.https://www.frontiersin.org/article/10.3389/fonc.2020.00597/fullphotodynamic therapymelanomaapoptosisautophagytumor immunity |
| spellingShingle | Xin-Ying Li Liu-Chang Tan Li-Wen Dong Wan-Qi Zhang Xiao-Xiao Shen Xiao Lu Hong Zheng Yuan-Gang Lu Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma Frontiers in Oncology photodynamic therapy melanoma apoptosis autophagy tumor immunity |
| title | Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma |
| title_full | Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma |
| title_fullStr | Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma |
| title_full_unstemmed | Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma |
| title_short | Susceptibility and Resistance Mechanisms During Photodynamic Therapy of Melanoma |
| title_sort | susceptibility and resistance mechanisms during photodynamic therapy of melanoma |
| topic | photodynamic therapy melanoma apoptosis autophagy tumor immunity |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.00597/full |
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