Cellular Organelles Involved in Hepatitis E Virus Infection
Hepatitis E virus (HEV), a major cause of acute hepatitis worldwide, infects approximately 20 million individuals annually. HEV can infect a wide range of mammalian and avian species, and cause frequent zoonotic spillover, increasingly raising public health concerns. To establish a successful infect...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/9/1206 |
| _version_ | 1797517626449068032 |
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| author | Xing Liu Menghang Wang Xin Yin |
| author_facet | Xing Liu Menghang Wang Xin Yin |
| author_sort | Xing Liu |
| collection | DOAJ |
| description | Hepatitis E virus (HEV), a major cause of acute hepatitis worldwide, infects approximately 20 million individuals annually. HEV can infect a wide range of mammalian and avian species, and cause frequent zoonotic spillover, increasingly raising public health concerns. To establish a successful infection, HEV needs to usurp host machineries to accomplish its life cycle from initial attachment to egress. However, relatively little is known about the HEV life cycle, especially the functional role(s) of cellular organelles and their associated proteins at different stages of HEV infection. Here, we summarize current knowledge regarding the relation of HEV with the different cell organelles during HEV infection. Furthermore, we discuss the underlying mechanisms by which HEV infection is precisely regulated in infected cells and the modification of host cell organelles and their associated proteins upon HEV infection. |
| first_indexed | 2024-03-10T07:19:09Z |
| format | Article |
| id | doaj.art-426cc9a47bdb40c483269d8eedf4d8ee |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T07:19:09Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-426cc9a47bdb40c483269d8eedf4d8ee2023-11-22T14:43:21ZengMDPI AGPathogens2076-08172021-09-01109120610.3390/pathogens10091206Cellular Organelles Involved in Hepatitis E Virus InfectionXing Liu0Menghang Wang1Xin Yin2State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, ChinaState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, ChinaHepatitis E virus (HEV), a major cause of acute hepatitis worldwide, infects approximately 20 million individuals annually. HEV can infect a wide range of mammalian and avian species, and cause frequent zoonotic spillover, increasingly raising public health concerns. To establish a successful infection, HEV needs to usurp host machineries to accomplish its life cycle from initial attachment to egress. However, relatively little is known about the HEV life cycle, especially the functional role(s) of cellular organelles and their associated proteins at different stages of HEV infection. Here, we summarize current knowledge regarding the relation of HEV with the different cell organelles during HEV infection. Furthermore, we discuss the underlying mechanisms by which HEV infection is precisely regulated in infected cells and the modification of host cell organelles and their associated proteins upon HEV infection.https://www.mdpi.com/2076-0817/10/9/1206hepatitis E viruscellular organelleslife cycle |
| spellingShingle | Xing Liu Menghang Wang Xin Yin Cellular Organelles Involved in Hepatitis E Virus Infection Pathogens hepatitis E virus cellular organelles life cycle |
| title | Cellular Organelles Involved in Hepatitis E Virus Infection |
| title_full | Cellular Organelles Involved in Hepatitis E Virus Infection |
| title_fullStr | Cellular Organelles Involved in Hepatitis E Virus Infection |
| title_full_unstemmed | Cellular Organelles Involved in Hepatitis E Virus Infection |
| title_short | Cellular Organelles Involved in Hepatitis E Virus Infection |
| title_sort | cellular organelles involved in hepatitis e virus infection |
| topic | hepatitis E virus cellular organelles life cycle |
| url | https://www.mdpi.com/2076-0817/10/9/1206 |
| work_keys_str_mv | AT xingliu cellularorganellesinvolvedinhepatitisevirusinfection AT menghangwang cellularorganellesinvolvedinhepatitisevirusinfection AT xinyin cellularorganellesinvolvedinhepatitisevirusinfection |