The Gut Microbiota Regulates Endocrine Vitamin D Metabolism through Fibroblast Growth Factor 23

The Gut Microbiota Regulates Endocrine Vitamin D Metabolism through Fibroblast Growth Factor 23

To determine the effect of the microbiota on vitamin D metabolism, serum 25-hydroxyvitamin D(25D), 24,25-dihydroxyvitamin D (24,25D), and 1,25-dihydroxyvitamin D (1,25D) were measured in germ-free (GF) mice before and after conventionalization (CN). GF mice had low levels of 25D, 24,25D, and 1,25D a...

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Bibliographic Details
Main Authors: Stephanie A. Bora, Mary J. Kennett, Philip B. Smith, Andrew D. Patterson, Margherita T. Cantorna
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
microbiota
fibroblast growth factor 23
vitamin D
inflammation
tumor necrosis factor-α
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00408/full

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