Mucormycosis: A new threat to Coronavirus disease 2019 with special emphasis on India
The main reason for the growth of mucormycosis in people with Coronavirus disease-2019 (COVID-19) is mainly produced by Rhizopus spp. The infective mechanisms and issues recognized in Rhizopus spp. are the cell wall, germination proteins, and enzymes assisted to iron sequestration, CotH protein, and...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Clinical Epidemiology and Global Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213398422000550 |
| _version_ | 1811332994955214848 |
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| author | Deganta Ghosh Sagardeep Dey Himanko Chakraborty Sneha Mukherjee Ankita Halder Akash Sarkar Pallab Chakraborty Rajdeep Ghosh Joy Sarkar |
| author_facet | Deganta Ghosh Sagardeep Dey Himanko Chakraborty Sneha Mukherjee Ankita Halder Akash Sarkar Pallab Chakraborty Rajdeep Ghosh Joy Sarkar |
| author_sort | Deganta Ghosh |
| collection | DOAJ |
| description | The main reason for the growth of mucormycosis in people with Coronavirus disease-2019 (COVID-19) is mainly produced by Rhizopus spp. The infective mechanisms and issues recognized in Rhizopus spp. are the cell wall, germination proteins, and enzymes assisted to iron sequestration, CotH protein, and positive regulation of the GRP78 cell receptor. Mucormycosis is mainly caused by the Rhizopus spp. such as R. oryzae, R. microsporus, R. arrhizus, R. homothallicus, etc. that are gifted to numerous host defense mechanisms and attribute to the endothelium via specific receptors, GRP78 simplifying their endocytosis and angio-invasion. Factors such as hyperglycemia, elevated iron concentrations, and ketoacidosis have been shown to contribute to the pathogenesis in the tentative situation. The analytical data of ‘black fungus disease’ or ‘mucormycosis’, specify India reported for about 42.3% of published cases, followed by the USA about 16.9%, Iraq, Bangladesh, Iran, Paraguay, and 1 case each from Brazil, Mexico, Italy, UK, China, France, Uruguay, Turkey, and Austria. The COVID-19 infection is maybe a predisposing factor for mucormycosis and is related to a high mortality rate. Early recognition and restriction of hyperglycemia, liposomal amphotericin B, and surgical debridement are the bases in the successful managing of mucormycosis. |
| first_indexed | 2024-04-13T16:45:24Z |
| format | Article |
| id | doaj.art-42735f7dd57644ee95a4a67af1d0a2c1 |
| institution | Directory Open Access Journal |
| issn | 2213-3984 |
| language | English |
| last_indexed | 2024-04-13T16:45:24Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Epidemiology and Global Health |
| spelling | doaj.art-42735f7dd57644ee95a4a67af1d0a2c12022-12-22T02:39:05ZengElsevierClinical Epidemiology and Global Health2213-39842022-05-0115101013Mucormycosis: A new threat to Coronavirus disease 2019 with special emphasis on IndiaDeganta Ghosh0Sagardeep Dey1Himanko Chakraborty2Sneha Mukherjee3Ankita Halder4Akash Sarkar5Pallab Chakraborty6Rajdeep Ghosh7Joy Sarkar8Department of Botany, Dinabandhu Andrews College, Garia, Kolkata, West Bengal, India, 700084Department of Botany, Dinabandhu Andrews College, Garia, Kolkata, West Bengal, India, 700084Department of Botany, Dinabandhu Andrews College, Garia, Kolkata, West Bengal, India, 700084Department of Botany, Dinabandhu Andrews College, Garia, Kolkata, West Bengal, India, 700084Department of Botany, Dinabandhu Andrews College, Garia, Kolkata, West Bengal, India, 700084Department of Botany, Dinabandhu Andrews College, Garia, Kolkata, West Bengal, India, 700084Department of Botany, Acharya Prafulla Chandra College, New Barrakpur, Kolkata, West Bengal, India, 700131GSL Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India, 533296Department of Botany, Dinabandhu Andrews College, Garia, Kolkata, West Bengal, India, 700084; Corresponding author.The main reason for the growth of mucormycosis in people with Coronavirus disease-2019 (COVID-19) is mainly produced by Rhizopus spp. The infective mechanisms and issues recognized in Rhizopus spp. are the cell wall, germination proteins, and enzymes assisted to iron sequestration, CotH protein, and positive regulation of the GRP78 cell receptor. Mucormycosis is mainly caused by the Rhizopus spp. such as R. oryzae, R. microsporus, R. arrhizus, R. homothallicus, etc. that are gifted to numerous host defense mechanisms and attribute to the endothelium via specific receptors, GRP78 simplifying their endocytosis and angio-invasion. Factors such as hyperglycemia, elevated iron concentrations, and ketoacidosis have been shown to contribute to the pathogenesis in the tentative situation. The analytical data of ‘black fungus disease’ or ‘mucormycosis’, specify India reported for about 42.3% of published cases, followed by the USA about 16.9%, Iraq, Bangladesh, Iran, Paraguay, and 1 case each from Brazil, Mexico, Italy, UK, China, France, Uruguay, Turkey, and Austria. The COVID-19 infection is maybe a predisposing factor for mucormycosis and is related to a high mortality rate. Early recognition and restriction of hyperglycemia, liposomal amphotericin B, and surgical debridement are the bases in the successful managing of mucormycosis.http://www.sciencedirect.com/science/article/pii/S2213398422000550CorticosteroidCOVID-19DiabeticsMucormycosisRhizopus |
| spellingShingle | Deganta Ghosh Sagardeep Dey Himanko Chakraborty Sneha Mukherjee Ankita Halder Akash Sarkar Pallab Chakraborty Rajdeep Ghosh Joy Sarkar Mucormycosis: A new threat to Coronavirus disease 2019 with special emphasis on India Clinical Epidemiology and Global Health Corticosteroid COVID-19 Diabetics Mucormycosis Rhizopus |
| title | Mucormycosis: A new threat to Coronavirus disease 2019 with special emphasis on India |
| title_full | Mucormycosis: A new threat to Coronavirus disease 2019 with special emphasis on India |
| title_fullStr | Mucormycosis: A new threat to Coronavirus disease 2019 with special emphasis on India |
| title_full_unstemmed | Mucormycosis: A new threat to Coronavirus disease 2019 with special emphasis on India |
| title_short | Mucormycosis: A new threat to Coronavirus disease 2019 with special emphasis on India |
| title_sort | mucormycosis a new threat to coronavirus disease 2019 with special emphasis on india |
| topic | Corticosteroid COVID-19 Diabetics Mucormycosis Rhizopus |
| url | http://www.sciencedirect.com/science/article/pii/S2213398422000550 |
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