Investigating the importance of left atrial compliance on fluid dynamics in a novel mock circulatory loop
Abstract The left atrium (LA) hemodynamic indices hold prognostic value in various cardiac diseases and disorders. To understand the mechanisms of these conditions and to assess the performance of cardiac devices and interventions, in vitro models can be used to replicate the complex physiological i...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-52327-6 |
| _version_ | 1827329137790943232 |
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| author | Masoud Meskin Philip Alexander Starkey Alexander Emil Kaspersen Steffen Ringgaard Signe Gram Sand Jens Vinge Nygaard Jørgen Arendt Jensen Marie Sand Traberg Peter Johansen |
| author_facet | Masoud Meskin Philip Alexander Starkey Alexander Emil Kaspersen Steffen Ringgaard Signe Gram Sand Jens Vinge Nygaard Jørgen Arendt Jensen Marie Sand Traberg Peter Johansen |
| author_sort | Masoud Meskin |
| collection | DOAJ |
| description | Abstract The left atrium (LA) hemodynamic indices hold prognostic value in various cardiac diseases and disorders. To understand the mechanisms of these conditions and to assess the performance of cardiac devices and interventions, in vitro models can be used to replicate the complex physiological interplay between the pulmonary veins, LA, and left ventricle. In this study, a comprehensive and adaptable in vitro model was created. The model includes a flexible LA made from silicone and allows distinct control over the systolic and diastolic functions of both the LA and left ventricle. The LA was mechanically matched with porcine LAs through expansion tests. Fluid dynamic measures were validated against the literature and pulmonary venous flows recorded on five healthy individuals using magnetic resonance flow imaging. Furthermore, the fluid dynamic measures were also used to construct LA pressure–volume loops. The in vitro pressure and flow recordings expressed a high resemblance to physiological waveforms. By decreasing the compliance of the LA, the model behaved realistically, elevating the a- and v-wave peaks of the LA pressure from 12 to 19 mmHg and 22 to 26 mmHg, respectively, while reducing the S/D ratio of the pulmonary venous flowrate from 1.5 to 0.3. This model provides a realistic platform and framework for developing and evaluating left heart procedures and interventions. |
| first_indexed | 2024-03-07T15:29:32Z |
| format | Article |
| id | doaj.art-4273c26aed2b492cb03f6c4422e8d62e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:29:32Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4273c26aed2b492cb03f6c4422e8d62e2024-03-05T16:29:59ZengNature PortfolioScientific Reports2045-23222024-01-0114111910.1038/s41598-024-52327-6Investigating the importance of left atrial compliance on fluid dynamics in a novel mock circulatory loopMasoud Meskin0Philip Alexander Starkey1Alexander Emil Kaspersen2Steffen Ringgaard3Signe Gram Sand4Jens Vinge Nygaard5Jørgen Arendt Jensen6Marie Sand Traberg7Peter Johansen8Cardiovascular Biomechanics Group, Department of Health Technology, Technical University of DenmarkCardiovascular Experimental Laboratory, Department of Electrical and Computer Engineering, Aarhus UniversityDepartment of Cardiothoracic and Vascular Surgery, Aarhus University HospitalMR Research Centre, Aarhus UniversityCardiovascular Experimental Laboratory, Department of Electrical and Computer Engineering, Aarhus UniversityBiomechanics and Mechanobiology, Department of Biological and Chemical Engineering, Aarhus UniversityCenter for Fast Ultrasound Imaging, Department of Health Technology, Technical University of DenmarkCardiovascular Biomechanics Group, Department of Health Technology, Technical University of DenmarkCardiovascular Experimental Laboratory, Department of Electrical and Computer Engineering, Aarhus UniversityAbstract The left atrium (LA) hemodynamic indices hold prognostic value in various cardiac diseases and disorders. To understand the mechanisms of these conditions and to assess the performance of cardiac devices and interventions, in vitro models can be used to replicate the complex physiological interplay between the pulmonary veins, LA, and left ventricle. In this study, a comprehensive and adaptable in vitro model was created. The model includes a flexible LA made from silicone and allows distinct control over the systolic and diastolic functions of both the LA and left ventricle. The LA was mechanically matched with porcine LAs through expansion tests. Fluid dynamic measures were validated against the literature and pulmonary venous flows recorded on five healthy individuals using magnetic resonance flow imaging. Furthermore, the fluid dynamic measures were also used to construct LA pressure–volume loops. The in vitro pressure and flow recordings expressed a high resemblance to physiological waveforms. By decreasing the compliance of the LA, the model behaved realistically, elevating the a- and v-wave peaks of the LA pressure from 12 to 19 mmHg and 22 to 26 mmHg, respectively, while reducing the S/D ratio of the pulmonary venous flowrate from 1.5 to 0.3. This model provides a realistic platform and framework for developing and evaluating left heart procedures and interventions.https://doi.org/10.1038/s41598-024-52327-6 |
| spellingShingle | Masoud Meskin Philip Alexander Starkey Alexander Emil Kaspersen Steffen Ringgaard Signe Gram Sand Jens Vinge Nygaard Jørgen Arendt Jensen Marie Sand Traberg Peter Johansen Investigating the importance of left atrial compliance on fluid dynamics in a novel mock circulatory loop Scientific Reports |
| title | Investigating the importance of left atrial compliance on fluid dynamics in a novel mock circulatory loop |
| title_full | Investigating the importance of left atrial compliance on fluid dynamics in a novel mock circulatory loop |
| title_fullStr | Investigating the importance of left atrial compliance on fluid dynamics in a novel mock circulatory loop |
| title_full_unstemmed | Investigating the importance of left atrial compliance on fluid dynamics in a novel mock circulatory loop |
| title_short | Investigating the importance of left atrial compliance on fluid dynamics in a novel mock circulatory loop |
| title_sort | investigating the importance of left atrial compliance on fluid dynamics in a novel mock circulatory loop |
| url | https://doi.org/10.1038/s41598-024-52327-6 |
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