BRAF Inhibitors in Non-Small Cell Lung Cancer

BRAF Inhibitors in Non-Small Cell Lung Cancer

RAF family proteins are serine–threonine kinases that play a central role in the MAPK pathway which is involved in embryogenesis, cell differentiation, cell proliferation and death. Deregulation of this pathway is found in up to 30% of all human cancers and BRAF mutations can be identified in 1.5–3....

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Bibliographic Details
Main Authors: Vincenzo Sforza, Giuliano Palumbo, Priscilla Cascetta, Guido Carillio, Anna Manzo, Agnese Montanino, Claudia Sandomenico, Raffaele Costanzo, Giovanna Esposito, Francesca Laudato, Simona Damiano, Cira Antonietta Forte, Giulia Frosini, Stefano Farese, Maria Carmela Piccirillo, Giacomo Pascarella, Nicola Normanno, Alessandro Morabito
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
NSCLC
BRAF
MEK
dabrafenib
trametinib
encorafenib
Online Access:https://www.mdpi.com/2072-6694/14/19/4863

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https://www.mdpi.com/2072-6694/14/19/4863

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