Role of Yes-Associated Protein in Psoriasis and Skin Tumor Pathogenesis
Psoriasis and skin tumors (such as basal cell carcinoma, squamous cell carcinoma, and melanoma) are chronic diseases that endanger physical and mental health, and yet the causes are largely unknown and treatment options limited. The development of targeted drugs requires a better understanding of th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/6/978 |
| _version_ | 1797485480449671168 |
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| author | Jinjing Jia Yuqian Wang Xiumei Mo Dacan Chen |
| author_facet | Jinjing Jia Yuqian Wang Xiumei Mo Dacan Chen |
| author_sort | Jinjing Jia |
| collection | DOAJ |
| description | Psoriasis and skin tumors (such as basal cell carcinoma, squamous cell carcinoma, and melanoma) are chronic diseases that endanger physical and mental health, and yet the causes are largely unknown and treatment options limited. The development of targeted drugs requires a better understanding of the exact pathogenesis of these diseases, and Yes-associated protein (YAP), a member of the Hippo signaling pathway, is believed to play an important role. Psoriasis and skin tumors are characterized by excessive cell proliferation, abnormal differentiation, vasodilation, and proliferation. Here, we review the literature related to YAP-associated disease mechanisms and discuss the latest research. YAP regulates cell apoptosis, proliferation, and differentiation; inhibits cell density and intercellular contacts and angiogenesis; and maintains the three-dimensional structure of the skin. These mechanisms may be associated with the occurrence and development of psoriasis and skin tumors. The results of recent studies have shown that YAP expression is increased in psoriasis and skin tumors. High expression of YAP in psoriasis and skin tumors may indicate its positive functions in skin inflammation and malignancies and may play an important role in disease pathogenesis. The study of new drugs targeting YAP can provide novel approaches for the treatment of skin diseases. |
| first_indexed | 2024-03-09T23:20:21Z |
| format | Article |
| id | doaj.art-4275f8cc7c1a4bd5b32520c9725dd3d6 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T23:20:21Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-4275f8cc7c1a4bd5b32520c9725dd3d62023-11-23T17:28:40ZengMDPI AGJournal of Personalized Medicine2075-44262022-06-0112697810.3390/jpm12060978Role of Yes-Associated Protein in Psoriasis and Skin Tumor PathogenesisJinjing Jia0Yuqian Wang1Xiumei Mo2Dacan Chen3State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, ChinaDepartment of Dermatology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710049, ChinaState Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, ChinaState Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, ChinaPsoriasis and skin tumors (such as basal cell carcinoma, squamous cell carcinoma, and melanoma) are chronic diseases that endanger physical and mental health, and yet the causes are largely unknown and treatment options limited. The development of targeted drugs requires a better understanding of the exact pathogenesis of these diseases, and Yes-associated protein (YAP), a member of the Hippo signaling pathway, is believed to play an important role. Psoriasis and skin tumors are characterized by excessive cell proliferation, abnormal differentiation, vasodilation, and proliferation. Here, we review the literature related to YAP-associated disease mechanisms and discuss the latest research. YAP regulates cell apoptosis, proliferation, and differentiation; inhibits cell density and intercellular contacts and angiogenesis; and maintains the three-dimensional structure of the skin. These mechanisms may be associated with the occurrence and development of psoriasis and skin tumors. The results of recent studies have shown that YAP expression is increased in psoriasis and skin tumors. High expression of YAP in psoriasis and skin tumors may indicate its positive functions in skin inflammation and malignancies and may play an important role in disease pathogenesis. The study of new drugs targeting YAP can provide novel approaches for the treatment of skin diseases.https://www.mdpi.com/2075-4426/12/6/978Yes-associated proteinHippo signaling pathwaypsoriasisskin tumorscutaneous squamous cell carcinomamelanoma |
| spellingShingle | Jinjing Jia Yuqian Wang Xiumei Mo Dacan Chen Role of Yes-Associated Protein in Psoriasis and Skin Tumor Pathogenesis Journal of Personalized Medicine Yes-associated protein Hippo signaling pathway psoriasis skin tumors cutaneous squamous cell carcinoma melanoma |
| title | Role of Yes-Associated Protein in Psoriasis and Skin Tumor Pathogenesis |
| title_full | Role of Yes-Associated Protein in Psoriasis and Skin Tumor Pathogenesis |
| title_fullStr | Role of Yes-Associated Protein in Psoriasis and Skin Tumor Pathogenesis |
| title_full_unstemmed | Role of Yes-Associated Protein in Psoriasis and Skin Tumor Pathogenesis |
| title_short | Role of Yes-Associated Protein in Psoriasis and Skin Tumor Pathogenesis |
| title_sort | role of yes associated protein in psoriasis and skin tumor pathogenesis |
| topic | Yes-associated protein Hippo signaling pathway psoriasis skin tumors cutaneous squamous cell carcinoma melanoma |
| url | https://www.mdpi.com/2075-4426/12/6/978 |
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