How Do mAbs Make Use of Complement to Kill Cancer Cells? The Role of Ca<sup>2+</sup>

How Do mAbs Make Use of Complement to Kill Cancer Cells? The Role of Ca<sup>2+</sup>

We examined the kinetics and mechanisms by which monoclonal antibodies (mAbs) utilize complement to rapidly kill targeted cancer cells. Based on results from flow cytometry, confocal microscopy and high-resolution digital imaging experiments, the general patterns which have emerged reveal cytotoxic...

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Bibliographic Details
Main Authors: Ronald P. Taylor, Margaret A. Lindorfer
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Antibodies
Subjects:
complement
therapeutic monoclonal antibodies (mAbs)
Ca<sup>2+</sup>
fluorescence microscopy
Online Access:https://www.mdpi.com/2073-4468/9/3/45

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