Viral suppression of multiple escape mutants by de novo CD8<sup>+ </sup>T cell responses in a human immunodeficiency virus-1 Infected elite suppressor
<p>Abstract</p> <p>Elite suppressors or controllers (ES) are HIV-1 infected patients who maintain undetectable viral loads without treatment. While HLA-B*57-positive ES are usually infected with virus that is unmutated at CTL epitopes, a single, dominant variant containing CTL esca...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-08-01
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| Series: | Retrovirology |
| Online Access: | http://www.retrovirology.com/content/8/1/63 |
| _version_ | 1818262825840148480 |
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| author | Siliciano Robert F Hegarty Robert W O'Connell Karen A Blankson Joel N |
| author_facet | Siliciano Robert F Hegarty Robert W O'Connell Karen A Blankson Joel N |
| author_sort | Siliciano Robert F |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Elite suppressors or controllers (ES) are HIV-1 infected patients who maintain undetectable viral loads without treatment. While HLA-B*57-positive ES are usually infected with virus that is unmutated at CTL epitopes, a single, dominant variant containing CTL escape mutations is typically seen in plasma during chronic infection. We describe an ES who developed seven distinct and rare escape variants at an HLA-B*57-restricted Gag epitope over a five year period. Interestingly, he developed proliferative, <it>de novo </it>CTL responses that suppressed replication of each of these variants. These responses, in combination with low viral fitness of each variant, may contribute to sustained elite control in this ES.</p> |
| first_indexed | 2024-12-12T19:09:17Z |
| format | Article |
| id | doaj.art-4277ca8c5e644989860e36e1c325d311 |
| institution | Directory Open Access Journal |
| issn | 1742-4690 |
| language | English |
| last_indexed | 2024-12-12T19:09:17Z |
| publishDate | 2011-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj.art-4277ca8c5e644989860e36e1c325d3112022-12-22T00:14:53ZengBMCRetrovirology1742-46902011-08-01816310.1186/1742-4690-8-63Viral suppression of multiple escape mutants by de novo CD8<sup>+ </sup>T cell responses in a human immunodeficiency virus-1 Infected elite suppressorSiliciano Robert FHegarty Robert WO'Connell Karen ABlankson Joel N<p>Abstract</p> <p>Elite suppressors or controllers (ES) are HIV-1 infected patients who maintain undetectable viral loads without treatment. While HLA-B*57-positive ES are usually infected with virus that is unmutated at CTL epitopes, a single, dominant variant containing CTL escape mutations is typically seen in plasma during chronic infection. We describe an ES who developed seven distinct and rare escape variants at an HLA-B*57-restricted Gag epitope over a five year period. Interestingly, he developed proliferative, <it>de novo </it>CTL responses that suppressed replication of each of these variants. These responses, in combination with low viral fitness of each variant, may contribute to sustained elite control in this ES.</p>http://www.retrovirology.com/content/8/1/63 |
| spellingShingle | Siliciano Robert F Hegarty Robert W O'Connell Karen A Blankson Joel N Viral suppression of multiple escape mutants by de novo CD8<sup>+ </sup>T cell responses in a human immunodeficiency virus-1 Infected elite suppressor Retrovirology |
| title | Viral suppression of multiple escape mutants by de novo CD8<sup>+ </sup>T cell responses in a human immunodeficiency virus-1 Infected elite suppressor |
| title_full | Viral suppression of multiple escape mutants by de novo CD8<sup>+ </sup>T cell responses in a human immunodeficiency virus-1 Infected elite suppressor |
| title_fullStr | Viral suppression of multiple escape mutants by de novo CD8<sup>+ </sup>T cell responses in a human immunodeficiency virus-1 Infected elite suppressor |
| title_full_unstemmed | Viral suppression of multiple escape mutants by de novo CD8<sup>+ </sup>T cell responses in a human immunodeficiency virus-1 Infected elite suppressor |
| title_short | Viral suppression of multiple escape mutants by de novo CD8<sup>+ </sup>T cell responses in a human immunodeficiency virus-1 Infected elite suppressor |
| title_sort | viral suppression of multiple escape mutants by de novo cd8 sup sup t cell responses in a human immunodeficiency virus 1 infected elite suppressor |
| url | http://www.retrovirology.com/content/8/1/63 |
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