Case Report of a Mare Diagnosed with a Metastatic Mammary Carcinoma after the Excision of a Recurrent Intraocular Neuroepithelial Tumor
A 24-year-old Irish Cob mare was presented with a peripheral iris mass, which was surgically resected and diagnosed as an undifferentiated neuroepithelial tumor. A few months later, a relapse occurred with histological features characterized by a more solid appearance and squamous differentiation. S...
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MDPI AG
2020-12-01
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| Online Access: | https://www.mdpi.com/2076-2615/10/12/2409 |
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| author | Ginevra Brocca Cinzia Centelleghe Elisa Padoan Riccardo Stoppini Chiara Giudice Massimo Castagnaro Valentina Zappulli |
| author_facet | Ginevra Brocca Cinzia Centelleghe Elisa Padoan Riccardo Stoppini Chiara Giudice Massimo Castagnaro Valentina Zappulli |
| author_sort | Ginevra Brocca |
| collection | DOAJ |
| description | A 24-year-old Irish Cob mare was presented with a peripheral iris mass, which was surgically resected and diagnosed as an undifferentiated neuroepithelial tumor. A few months later, a relapse occurred with histological features characterized by a more solid appearance and squamous differentiation. Subsequently, the mare was presented with rapidly spreading multiple subcutaneous masses and, at the onset of neurological signs, was humanely euthanized and subjected to a complete post mortem examination. The necropsy confirmed the presence of numerous widespread masses in the subcutaneous tissue, several internal organs, and mammary gland. Histological and immunohistochemical (IHC) examinations were performed on all masses, allowing the diagnosis of mammary carcinoma with several visceral and subcutaneous metastases. Considering the post mortem findings, the second intraocular mass was submitted to histological and IHC re-evaluation to differentiate it from an intraocular metastasis of the mammary carcinoma. The results of the histological and IHC analyses confirmed the diagnosis of neuroepithelial tumor relapse. This is the first case of a metastatic mammary carcinoma concurrent with a recurrent intraocular neuroepithelial tumor in a mare. This case was a challenge for both clinicians and pathologists involved and highlighted the importance of post mortem and IHC evaluations. |
| first_indexed | 2024-03-10T14:00:54Z |
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| id | doaj.art-427893e9dd7441a685de8fa66d3b584e |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T14:00:54Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-427893e9dd7441a685de8fa66d3b584e2023-11-21T01:05:35ZengMDPI AGAnimals2076-26152020-12-011012240910.3390/ani10122409Case Report of a Mare Diagnosed with a Metastatic Mammary Carcinoma after the Excision of a Recurrent Intraocular Neuroepithelial TumorGinevra Brocca0Cinzia Centelleghe1Elisa Padoan2Riccardo Stoppini3Chiara Giudice4Massimo Castagnaro5Valentina Zappulli6Department of Comparative Biomedicine and Food Science, University of Padua, Legnaro, 35020 Padua, ItalyDepartment of Comparative Biomedicine and Food Science, University of Padua, Legnaro, 35020 Padua, ItalyEquine Veterinary Practitioner, Chioggia, 30015 Venice, ItalyConsultant in Equine Ophthalmology, Lonato del Garda, 25017 Brescia, ItalyDepartment of Veterinary Medicine, University of Milan, Lodi, 26900 Lodi, ItalyDepartment of Comparative Biomedicine and Food Science, University of Padua, Legnaro, 35020 Padua, ItalyDepartment of Comparative Biomedicine and Food Science, University of Padua, Legnaro, 35020 Padua, ItalyA 24-year-old Irish Cob mare was presented with a peripheral iris mass, which was surgically resected and diagnosed as an undifferentiated neuroepithelial tumor. A few months later, a relapse occurred with histological features characterized by a more solid appearance and squamous differentiation. Subsequently, the mare was presented with rapidly spreading multiple subcutaneous masses and, at the onset of neurological signs, was humanely euthanized and subjected to a complete post mortem examination. The necropsy confirmed the presence of numerous widespread masses in the subcutaneous tissue, several internal organs, and mammary gland. Histological and immunohistochemical (IHC) examinations were performed on all masses, allowing the diagnosis of mammary carcinoma with several visceral and subcutaneous metastases. Considering the post mortem findings, the second intraocular mass was submitted to histological and IHC re-evaluation to differentiate it from an intraocular metastasis of the mammary carcinoma. The results of the histological and IHC analyses confirmed the diagnosis of neuroepithelial tumor relapse. This is the first case of a metastatic mammary carcinoma concurrent with a recurrent intraocular neuroepithelial tumor in a mare. This case was a challenge for both clinicians and pathologists involved and highlighted the importance of post mortem and IHC evaluations.https://www.mdpi.com/2076-2615/10/12/2409eyehistologyimmunohistochemistrymammary carcinomamammary glandmetastasis |
| spellingShingle | Ginevra Brocca Cinzia Centelleghe Elisa Padoan Riccardo Stoppini Chiara Giudice Massimo Castagnaro Valentina Zappulli Case Report of a Mare Diagnosed with a Metastatic Mammary Carcinoma after the Excision of a Recurrent Intraocular Neuroepithelial Tumor Animals eye histology immunohistochemistry mammary carcinoma mammary gland metastasis |
| title | Case Report of a Mare Diagnosed with a Metastatic Mammary Carcinoma after the Excision of a Recurrent Intraocular Neuroepithelial Tumor |
| title_full | Case Report of a Mare Diagnosed with a Metastatic Mammary Carcinoma after the Excision of a Recurrent Intraocular Neuroepithelial Tumor |
| title_fullStr | Case Report of a Mare Diagnosed with a Metastatic Mammary Carcinoma after the Excision of a Recurrent Intraocular Neuroepithelial Tumor |
| title_full_unstemmed | Case Report of a Mare Diagnosed with a Metastatic Mammary Carcinoma after the Excision of a Recurrent Intraocular Neuroepithelial Tumor |
| title_short | Case Report of a Mare Diagnosed with a Metastatic Mammary Carcinoma after the Excision of a Recurrent Intraocular Neuroepithelial Tumor |
| title_sort | case report of a mare diagnosed with a metastatic mammary carcinoma after the excision of a recurrent intraocular neuroepithelial tumor |
| topic | eye histology immunohistochemistry mammary carcinoma mammary gland metastasis |
| url | https://www.mdpi.com/2076-2615/10/12/2409 |
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