Composite Nanoarchitectonics of Photoactivated Titania-Based Materials with Anticancer Properties
The synthesis of titania-based composite materials with anticancer potential under visible-light irradiation is the aim of this study. In specific, titanium dioxide (TiO<sub>2</sub>) nanoparticles (NPs) chemically modified with silver were embedded in a stimuli-responsive microgel (a cro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/1/135 |
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| author | Nefeli Papadopoulou-Fermeli Nefeli Lagopati Natassa Pippa Elias Sakellis Nikos Boukos Vassilis G. Gorgoulis Maria Gazouli Evangelia A. Pavlatou |
| author_facet | Nefeli Papadopoulou-Fermeli Nefeli Lagopati Natassa Pippa Elias Sakellis Nikos Boukos Vassilis G. Gorgoulis Maria Gazouli Evangelia A. Pavlatou |
| author_sort | Nefeli Papadopoulou-Fermeli |
| collection | DOAJ |
| description | The synthesis of titania-based composite materials with anticancer potential under visible-light irradiation is the aim of this study. In specific, titanium dioxide (TiO<sub>2</sub>) nanoparticles (NPs) chemically modified with silver were embedded in a stimuli-responsive microgel (a crosslinked interpenetrating network (IP) network that was synthesized by poly (N-Isopropylacrylamide) and linear chains of polyacrylic acid sodium salt, forming composite particles. The ultimate goal of this research, and for our future plans, is to develop a drug-delivery system that uses optical fibers that could efficiently photoactivate NPs, targeting cancer cells. The produced Ag-TiO<sub>2</sub> NPs, the microgel and the composite materials were characterized through X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), micro-Raman spectroscopy, ultraviolet-visible spectroscopy (UV-Vis), dynamic light scattering (DLS) and transmission electron microscopy (TEM). Our results indicated that Ag-TiO<sub>2</sub> NPs were successfully embedded within the thermoresponsive microgel. Either Ag-TiO<sub>2</sub> NPs or the composite materials exhibited high photocatalytic degradation efficiency on the pollutant rhodamine B and significant anticancer potential under visible-light irradiation. |
| first_indexed | 2024-03-09T11:27:24Z |
| format | Article |
| id | doaj.art-427977343c3b4fa1b14704bc38fd6bdf |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T11:27:24Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-427977343c3b4fa1b14704bc38fd6bdf2023-11-30T23:58:12ZengMDPI AGPharmaceutics1999-49232022-12-0115113510.3390/pharmaceutics15010135Composite Nanoarchitectonics of Photoactivated Titania-Based Materials with Anticancer PropertiesNefeli Papadopoulou-Fermeli0Nefeli Lagopati1Natassa Pippa2Elias Sakellis3Nikos Boukos4Vassilis G. Gorgoulis5Maria Gazouli6Evangelia A. Pavlatou7Laboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, 15789 Zografou, GreeceLaboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, 15789 Zografou, GreeceSection of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, GreeceInstitute of Nanoscience and Nanotechnology, National Center for Scientific Research “Demokritos”, 15310 Agia Paraskevi, GreeceInstitute of Nanoscience and Nanotechnology, National Center for Scientific Research “Demokritos”, 15310 Agia Paraskevi, GreeceLaboratory of Histology-Embryology, Molecular Carcinogenesis Group, Department of Basic Medical Sciences, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceLaboratory of Biology, Department of Basic Medical Sciences, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceLaboratory of General Chemistry, School of Chemical Engineering, National Technical University of Athens, Zografou Campus, 15789 Zografou, GreeceThe synthesis of titania-based composite materials with anticancer potential under visible-light irradiation is the aim of this study. In specific, titanium dioxide (TiO<sub>2</sub>) nanoparticles (NPs) chemically modified with silver were embedded in a stimuli-responsive microgel (a crosslinked interpenetrating network (IP) network that was synthesized by poly (N-Isopropylacrylamide) and linear chains of polyacrylic acid sodium salt, forming composite particles. The ultimate goal of this research, and for our future plans, is to develop a drug-delivery system that uses optical fibers that could efficiently photoactivate NPs, targeting cancer cells. The produced Ag-TiO<sub>2</sub> NPs, the microgel and the composite materials were characterized through X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), micro-Raman spectroscopy, ultraviolet-visible spectroscopy (UV-Vis), dynamic light scattering (DLS) and transmission electron microscopy (TEM). Our results indicated that Ag-TiO<sub>2</sub> NPs were successfully embedded within the thermoresponsive microgel. Either Ag-TiO<sub>2</sub> NPs or the composite materials exhibited high photocatalytic degradation efficiency on the pollutant rhodamine B and significant anticancer potential under visible-light irradiation.https://www.mdpi.com/1999-4923/15/1/135composite materialsAg-TiO<sub>2</sub>sol-gelvisible lightphotocatalysisPNIPAM |
| spellingShingle | Nefeli Papadopoulou-Fermeli Nefeli Lagopati Natassa Pippa Elias Sakellis Nikos Boukos Vassilis G. Gorgoulis Maria Gazouli Evangelia A. Pavlatou Composite Nanoarchitectonics of Photoactivated Titania-Based Materials with Anticancer Properties Pharmaceutics composite materials Ag-TiO<sub>2</sub> sol-gel visible light photocatalysis PNIPAM |
| title | Composite Nanoarchitectonics of Photoactivated Titania-Based Materials with Anticancer Properties |
| title_full | Composite Nanoarchitectonics of Photoactivated Titania-Based Materials with Anticancer Properties |
| title_fullStr | Composite Nanoarchitectonics of Photoactivated Titania-Based Materials with Anticancer Properties |
| title_full_unstemmed | Composite Nanoarchitectonics of Photoactivated Titania-Based Materials with Anticancer Properties |
| title_short | Composite Nanoarchitectonics of Photoactivated Titania-Based Materials with Anticancer Properties |
| title_sort | composite nanoarchitectonics of photoactivated titania based materials with anticancer properties |
| topic | composite materials Ag-TiO<sub>2</sub> sol-gel visible light photocatalysis PNIPAM |
| url | https://www.mdpi.com/1999-4923/15/1/135 |
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