A dynamic RNA loop in an IRES affects multiple steps of elongation factor-mediated translation initiation

A dynamic RNA loop in an IRES affects multiple steps of elongation factor-mediated translation initiation

Internal ribosome entry sites (IRESs) are powerful model systems to understand how the translation machinery can be manipulated by structured RNAs and for exploring inherent features of ribosome function. The intergenic region (IGR) IRESs from the Dicistroviridae family of viruses are structured RNA...

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Bibliographic Details
Main Authors: Marisa D Ruehle, Haibo Zhang, Ryan M Sheridan, Somdeb Mitra, Yuanwei Chen, Ruben L Gonzalez Jr, Barry S Cooperman, Jeffrey S Kieft
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-11-01
Series:eLife
Subjects:
IGR IRES RNA
translation initiation
pseudotranslocation
pseudoknot
Online Access:https://elifesciences.org/articles/08146

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