The Combined Treatment of Glutathione Sodium Salt and Ascorbic Acid for Preventing Contrast-Associated Acute Kidney Injury in ST-Elevation Myocardial Infarction Patients Undergoing Primary PCI: A Hypothesis to Be Validated
The occurrence of Contrast-Associated Acute Kidney Injury (CA-AKI) in patients with ST-Elevation Myocardial Infarction (STEMI) has a negative impact on the length of hospital stay and mortality. Reactive Oxygen Species (ROS) release, along with vasoconstriction and hypoperfusion, play a key role in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/3/773 |
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| author | Alessio Arrivi Giovanni Truscelli Giacomo Pucci Francesco Barillà Roberto Carnevale Cristina Nocella Martina Sordi Marcello Dominici Gaetano Tanzilli Enrico Mangieri |
| author_facet | Alessio Arrivi Giovanni Truscelli Giacomo Pucci Francesco Barillà Roberto Carnevale Cristina Nocella Martina Sordi Marcello Dominici Gaetano Tanzilli Enrico Mangieri |
| author_sort | Alessio Arrivi |
| collection | DOAJ |
| description | The occurrence of Contrast-Associated Acute Kidney Injury (CA-AKI) in patients with ST-Elevation Myocardial Infarction (STEMI) has a negative impact on the length of hospital stay and mortality. Reactive Oxygen Species (ROS) release, along with vasoconstriction and hypoperfusion, play a key role in its development. To date, there is still no validated prophylactic therapy for this disease. The use of antioxidants, based on experimental and clinical studies, looks promising. Taking into consideration previous literature, we speculate that an early, combined and prolonged intravenous administration of both Glutathione (GSH) and ascorbic acid in STEMI patients undergoing primary Percutaneous Coronary Intervention (pPCI) may be of value in counteracting the occurrence of CA-AKI. We aimed at evaluating this hypothesis by applying a multicenter research protocol, using a double-blind randomized, placebo-controlled trial design. The primary endpoint will be to test the efficacy of this combined antioxidant therapy in reducing the occurrence of renal damage, in patients with acute myocardial infarction treated with pPCI. Furthermore, we will investigate the effect of the study compounds on changes in oxidative stress markers and platelet activation levels through bio-humoral analyses. |
| first_indexed | 2024-03-11T06:59:24Z |
| format | Article |
| id | doaj.art-4280a92da87747b19b5ea246f9c55aa5 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T06:59:24Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-4280a92da87747b19b5ea246f9c55aa52023-11-17T09:19:34ZengMDPI AGAntioxidants2076-39212023-03-0112377310.3390/antiox12030773The Combined Treatment of Glutathione Sodium Salt and Ascorbic Acid for Preventing Contrast-Associated Acute Kidney Injury in ST-Elevation Myocardial Infarction Patients Undergoing Primary PCI: A Hypothesis to Be ValidatedAlessio Arrivi0Giovanni Truscelli1Giacomo Pucci2Francesco Barillà3Roberto Carnevale4Cristina Nocella5Martina Sordi6Marcello Dominici7Gaetano Tanzilli8Enrico Mangieri9Interventional Cardiology Unit, “Santa Maria” University Hospital, 05100 Terni, ItalyDivision of Cardiology, Bios Group, 00197 Rome, ItalyUnit of Internal Medicine, S. Maria University Hospital, 05100 Terni, ItalyDepartment of Systems Medicine, University Tor Vergata, 00133 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies Sapienza University, 04100 Latina, ItalyDepartment of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, ItalyInterventional Cardiology Unit, “Santa Maria” University Hospital, 05100 Terni, ItalyInterventional Cardiology Unit, “Santa Maria” University Hospital, 05100 Terni, ItalyDepartment of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Clinical, Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, ItalyThe occurrence of Contrast-Associated Acute Kidney Injury (CA-AKI) in patients with ST-Elevation Myocardial Infarction (STEMI) has a negative impact on the length of hospital stay and mortality. Reactive Oxygen Species (ROS) release, along with vasoconstriction and hypoperfusion, play a key role in its development. To date, there is still no validated prophylactic therapy for this disease. The use of antioxidants, based on experimental and clinical studies, looks promising. Taking into consideration previous literature, we speculate that an early, combined and prolonged intravenous administration of both Glutathione (GSH) and ascorbic acid in STEMI patients undergoing primary Percutaneous Coronary Intervention (pPCI) may be of value in counteracting the occurrence of CA-AKI. We aimed at evaluating this hypothesis by applying a multicenter research protocol, using a double-blind randomized, placebo-controlled trial design. The primary endpoint will be to test the efficacy of this combined antioxidant therapy in reducing the occurrence of renal damage, in patients with acute myocardial infarction treated with pPCI. Furthermore, we will investigate the effect of the study compounds on changes in oxidative stress markers and platelet activation levels through bio-humoral analyses.https://www.mdpi.com/2076-3921/12/3/773contrast-associated acute kidney injuryglutathioneascorbic acidSTEMIprimary percutaneous coronary intervention |
| spellingShingle | Alessio Arrivi Giovanni Truscelli Giacomo Pucci Francesco Barillà Roberto Carnevale Cristina Nocella Martina Sordi Marcello Dominici Gaetano Tanzilli Enrico Mangieri The Combined Treatment of Glutathione Sodium Salt and Ascorbic Acid for Preventing Contrast-Associated Acute Kidney Injury in ST-Elevation Myocardial Infarction Patients Undergoing Primary PCI: A Hypothesis to Be Validated Antioxidants contrast-associated acute kidney injury glutathione ascorbic acid STEMI primary percutaneous coronary intervention |
| title | The Combined Treatment of Glutathione Sodium Salt and Ascorbic Acid for Preventing Contrast-Associated Acute Kidney Injury in ST-Elevation Myocardial Infarction Patients Undergoing Primary PCI: A Hypothesis to Be Validated |
| title_full | The Combined Treatment of Glutathione Sodium Salt and Ascorbic Acid for Preventing Contrast-Associated Acute Kidney Injury in ST-Elevation Myocardial Infarction Patients Undergoing Primary PCI: A Hypothesis to Be Validated |
| title_fullStr | The Combined Treatment of Glutathione Sodium Salt and Ascorbic Acid for Preventing Contrast-Associated Acute Kidney Injury in ST-Elevation Myocardial Infarction Patients Undergoing Primary PCI: A Hypothesis to Be Validated |
| title_full_unstemmed | The Combined Treatment of Glutathione Sodium Salt and Ascorbic Acid for Preventing Contrast-Associated Acute Kidney Injury in ST-Elevation Myocardial Infarction Patients Undergoing Primary PCI: A Hypothesis to Be Validated |
| title_short | The Combined Treatment of Glutathione Sodium Salt and Ascorbic Acid for Preventing Contrast-Associated Acute Kidney Injury in ST-Elevation Myocardial Infarction Patients Undergoing Primary PCI: A Hypothesis to Be Validated |
| title_sort | combined treatment of glutathione sodium salt and ascorbic acid for preventing contrast associated acute kidney injury in st elevation myocardial infarction patients undergoing primary pci a hypothesis to be validated |
| topic | contrast-associated acute kidney injury glutathione ascorbic acid STEMI primary percutaneous coronary intervention |
| url | https://www.mdpi.com/2076-3921/12/3/773 |
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