Effect of estrogen administration on middle cerebral arterial viscoelastic properties in aged female rats
ABSTRACT PURPOSE: To develop a model for studying cerebrovascular disease prevention in elderly women. METHODS: Sixty 18-month-old Sprague Dawley (SD) rats were randomly divided into an estrogen administration group (EA, n=30) and a non-administration group (NA, n=30); thirty 4-month-old SD rats w...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2016-10-01
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| Series: | Acta Cirúrgica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/pdf/acb/v31n10/1678-2674-acb-31-10-00661.pdf |
| _version_ | 1818916819519406080 |
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| author | Zhigang Qin Guijie Li Naijie Liu Conghai Zhao Hang Zhao |
| author_facet | Zhigang Qin Guijie Li Naijie Liu Conghai Zhao Hang Zhao |
| author_sort | Zhigang Qin |
| collection | DOAJ |
| description | ABSTRACT PURPOSE: To develop a model for studying cerebrovascular disease prevention in elderly women. METHODS: Sixty 18-month-old Sprague Dawley (SD) rats were randomly divided into an estrogen administration group (EA, n=30) and a non-administration group (NA, n=30); thirty 4-month-old SD rats were allocated to a control group. The EA group received estradiol benzoate starting on the 5th day of a 34-day breeding period, and the serum levels of estradiol (E2), estrogen receptor (ER), and malondialdehyde (MDA) were measured. The MCA of each group was then sampled for viscoelastic experiments. RESULTS: The serum levels of E2 and MDA in the EA group showed significant differences compared to those in the control group (p<0.05), while the difference in ER between the EA and control groups was not significant (p>0.05). The decrease in MCA stress at 7,200 s and the increase in strain at 7,200 s in the EA group showed no significant differences compared to the control group (p>0.05). CONCLUSION: Estradiol administration inhibited the formation of lipid peroxidation products and restored middle cerebral arterial viscoelasticity in aged female rats. |
| first_indexed | 2024-12-20T00:24:14Z |
| format | Article |
| id | doaj.art-42817cc1ebcd4676802bd2cd252b0021 |
| institution | Directory Open Access Journal |
| issn | 0102-8650 |
| language | English |
| last_indexed | 2024-12-20T00:24:14Z |
| publishDate | 2016-10-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj.art-42817cc1ebcd4676802bd2cd252b00212022-12-21T20:00:07ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira0102-86502016-10-01311066166710.1590/S0102-865020160100000004Effect of estrogen administration on middle cerebral arterial viscoelastic properties in aged female ratsZhigang QinGuijie LiNaijie LiuConghai ZhaoHang ZhaoABSTRACT PURPOSE: To develop a model for studying cerebrovascular disease prevention in elderly women. METHODS: Sixty 18-month-old Sprague Dawley (SD) rats were randomly divided into an estrogen administration group (EA, n=30) and a non-administration group (NA, n=30); thirty 4-month-old SD rats were allocated to a control group. The EA group received estradiol benzoate starting on the 5th day of a 34-day breeding period, and the serum levels of estradiol (E2), estrogen receptor (ER), and malondialdehyde (MDA) were measured. The MCA of each group was then sampled for viscoelastic experiments. RESULTS: The serum levels of E2 and MDA in the EA group showed significant differences compared to those in the control group (p<0.05), while the difference in ER between the EA and control groups was not significant (p>0.05). The decrease in MCA stress at 7,200 s and the increase in strain at 7,200 s in the EA group showed no significant differences compared to the control group (p>0.05). CONCLUSION: Estradiol administration inhibited the formation of lipid peroxidation products and restored middle cerebral arterial viscoelasticity in aged female rats.http://www.scielo.br/pdf/acb/v31n10/1678-2674-acb-31-10-00661.pdfAgingEstrogensMiddle Cerebral ArteryFemaleRats |
| spellingShingle | Zhigang Qin Guijie Li Naijie Liu Conghai Zhao Hang Zhao Effect of estrogen administration on middle cerebral arterial viscoelastic properties in aged female rats Acta Cirúrgica Brasileira Aging Estrogens Middle Cerebral Artery Female Rats |
| title | Effect of estrogen administration on middle cerebral arterial viscoelastic properties in aged female rats |
| title_full | Effect of estrogen administration on middle cerebral arterial viscoelastic properties in aged female rats |
| title_fullStr | Effect of estrogen administration on middle cerebral arterial viscoelastic properties in aged female rats |
| title_full_unstemmed | Effect of estrogen administration on middle cerebral arterial viscoelastic properties in aged female rats |
| title_short | Effect of estrogen administration on middle cerebral arterial viscoelastic properties in aged female rats |
| title_sort | effect of estrogen administration on middle cerebral arterial viscoelastic properties in aged female rats |
| topic | Aging Estrogens Middle Cerebral Artery Female Rats |
| url | http://www.scielo.br/pdf/acb/v31n10/1678-2674-acb-31-10-00661.pdf |
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