Assessment of the proarrhythmic effects of repurposed antimalarials for COVID-19 treatment using a comprehensive in vitro proarrhythmia assay (CiPA)

Assessment of the proarrhythmic effects of repurposed antimalarials for COVID-19 treatment using a comprehensive in vitro proarrhythmia assay (CiPA)

Due to the outbreak of the SARS-CoV-2 virus, drug repurposing and Emergency Use Authorization have been proposed to treat the coronavirus disease 2019 (COVID-19) during the pandemic. While the efficiency of the drugs has been discussed, it was identified that certain compounds, such as chloroquine a...

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Bibliographic Details
Main Authors: Seung-Hyun Yoon, Hyun-Lee Lee, Da Un Jeong, Ki Moo Lim, Seong-Jun Park, Ki-Suk Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Pharmacology
Subjects:
CiPA
cardiotoxicity
COVID-19
electrophysiology
antimalarials
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1220796/full

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