Association between urinary biomarkers of polycyclic aromatic hydrocarbons and severe abdominal aortic calcification in adults: data from the National Health and Examination Nutrition Survey
Abstract Objective Recent studies have found that polycyclic aromatic hydrocarbons (PAHs) exposure may increase the risk of cardiovascular disease. The present study aimed to explore the association between PAHs exposure and severe abdominal aortic calcification (AAC) in adults. Methods Data were co...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-023-03122-0 |
| _version_ | 1797865597672882176 |
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| author | Xi Yang Haobin Zhou Hao Zhang Peijian Zhang Zhikang Zheng Dingli Xu Qingchun Zeng |
| author_facet | Xi Yang Haobin Zhou Hao Zhang Peijian Zhang Zhikang Zheng Dingli Xu Qingchun Zeng |
| author_sort | Xi Yang |
| collection | DOAJ |
| description | Abstract Objective Recent studies have found that polycyclic aromatic hydrocarbons (PAHs) exposure may increase the risk of cardiovascular disease. The present study aimed to explore the association between PAHs exposure and severe abdominal aortic calcification (AAC) in adults. Methods Data were collected from the 2013–2014 National Health and Nutrition Examination Survey. PAHs exposure was analyzed from urinary mono hydroxylated metabolites of PAHs. Logistic regression models and subgroup analysis were performed to explore the association of PAHs exposure with severe AAC prevalence. Results A total of 1,005 eligible individuals were recruited into the study. After adjusting for confounding factors, those with the highest quartiles of 1-hydroxynaphthalene (1-NAP: OR 2.19, 95% CI 1.03–4.68, P for trend < 0.001), 2-hydroxynaphthalene (2-NAP: OR 2.22, 95% CI 1.04–4.64, P for trend < 0.001) and 1-hydroxypyrene (1-PYR: OR 2.15, 95% CI 1.06–4.33, P for trend < 0.001) were associated with an increased prevalence of severe AAC in the adults compared to those who in the lowest quartile. Conclusion This study found that urinary 1-NAP, 2-NAP and 1-PYR were positively associated with severe AAC prevalence in adults. |
| first_indexed | 2024-04-09T23:11:48Z |
| format | Article |
| id | doaj.art-428ad7782bda451999459ffcf4cd025e |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-09T23:11:48Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-428ad7782bda451999459ffcf4cd025e2023-03-22T10:22:30ZengBMCBMC Cardiovascular Disorders1471-22612023-02-012311810.1186/s12872-023-03122-0Association between urinary biomarkers of polycyclic aromatic hydrocarbons and severe abdominal aortic calcification in adults: data from the National Health and Examination Nutrition SurveyXi Yang0Haobin Zhou1Hao Zhang2Peijian Zhang3Zhikang Zheng4Dingli Xu5Qingchun Zeng6State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical UniversityDepartment of Cardiology, The First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical UniversityCardiovascular Medicine Department, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical UniversityState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical UniversityState Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical UniversityAbstract Objective Recent studies have found that polycyclic aromatic hydrocarbons (PAHs) exposure may increase the risk of cardiovascular disease. The present study aimed to explore the association between PAHs exposure and severe abdominal aortic calcification (AAC) in adults. Methods Data were collected from the 2013–2014 National Health and Nutrition Examination Survey. PAHs exposure was analyzed from urinary mono hydroxylated metabolites of PAHs. Logistic regression models and subgroup analysis were performed to explore the association of PAHs exposure with severe AAC prevalence. Results A total of 1,005 eligible individuals were recruited into the study. After adjusting for confounding factors, those with the highest quartiles of 1-hydroxynaphthalene (1-NAP: OR 2.19, 95% CI 1.03–4.68, P for trend < 0.001), 2-hydroxynaphthalene (2-NAP: OR 2.22, 95% CI 1.04–4.64, P for trend < 0.001) and 1-hydroxypyrene (1-PYR: OR 2.15, 95% CI 1.06–4.33, P for trend < 0.001) were associated with an increased prevalence of severe AAC in the adults compared to those who in the lowest quartile. Conclusion This study found that urinary 1-NAP, 2-NAP and 1-PYR were positively associated with severe AAC prevalence in adults.https://doi.org/10.1186/s12872-023-03122-0Abdominal aortic calcificationPAHs exposureNHANESLogistic regression |
| spellingShingle | Xi Yang Haobin Zhou Hao Zhang Peijian Zhang Zhikang Zheng Dingli Xu Qingchun Zeng Association between urinary biomarkers of polycyclic aromatic hydrocarbons and severe abdominal aortic calcification in adults: data from the National Health and Examination Nutrition Survey BMC Cardiovascular Disorders Abdominal aortic calcification PAHs exposure NHANES Logistic regression |
| title | Association between urinary biomarkers of polycyclic aromatic hydrocarbons and severe abdominal aortic calcification in adults: data from the National Health and Examination Nutrition Survey |
| title_full | Association between urinary biomarkers of polycyclic aromatic hydrocarbons and severe abdominal aortic calcification in adults: data from the National Health and Examination Nutrition Survey |
| title_fullStr | Association between urinary biomarkers of polycyclic aromatic hydrocarbons and severe abdominal aortic calcification in adults: data from the National Health and Examination Nutrition Survey |
| title_full_unstemmed | Association between urinary biomarkers of polycyclic aromatic hydrocarbons and severe abdominal aortic calcification in adults: data from the National Health and Examination Nutrition Survey |
| title_short | Association between urinary biomarkers of polycyclic aromatic hydrocarbons and severe abdominal aortic calcification in adults: data from the National Health and Examination Nutrition Survey |
| title_sort | association between urinary biomarkers of polycyclic aromatic hydrocarbons and severe abdominal aortic calcification in adults data from the national health and examination nutrition survey |
| topic | Abdominal aortic calcification PAHs exposure NHANES Logistic regression |
| url | https://doi.org/10.1186/s12872-023-03122-0 |
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