Tanshinone IIA Exerts Anti-Inflammatory and Immune-Regulating Effects on Vulnerable Atherosclerotic Plaque Partially via the TLR4/MyD88/NF-κB Signal Pathway

Tanshinone IIA Exerts Anti-Inflammatory and Immune-Regulating Effects on Vulnerable Atherosclerotic Plaque Partially via the TLR4/MyD88/NF-κB Signal Pathway

Background: Tanshinone IIA (Tan IIA), a lipophilic constituent from Salvia miltiorrhiza Bunge, has shown a promising cardioprotective effect including anti-atherosclerosis. This study aims at exploring Tan IIA’s anti-inflammatory and immune-regulating roles in stabilizing vulnerable atherosclerotic...

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Bibliographic Details
Main Authors: Zhuo Chen, Xiang Gao, Yang Jiao, Yu Qiu, Anlu Wang, Meili Yu, Fangyuan Che, Siming Li, Jing Liu, Jingen Li, He Zhang, Changan Yu, Geng Li, Yanxiang Gao, Lin Pan, Weiliang Sun, Jing Guo, Bingyan Cao, Yilin Zhu, Hao Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Pharmacology
Subjects:
Tanshinone IIA
atherosclerosis
anti-inflammatory
immune regulation
TLR4/MyD88/NF-κB
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00850/full

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