Relationships between 25-Hydroxyvitamin D Levels and Obstructive Sleep Apnea Severity in Children: An Observational Study
The prevalence of hypovitaminosis D is increasing worldwide. Vitamin D deficiency is supposed to play a role in sleep disturbances, but the complex relationships between hypovitaminosis D and pediatric obstructive sleep apnea syndrome (OSAS) are still incompletely understood. This study was aimed to...
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/3/1242 |
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| author | Cristian Locci Antonella Ruiu Laura Saderi Giovanni Sotgiu Stefania Bassu Marco Zaffanello Roberto Antonucci |
| author_facet | Cristian Locci Antonella Ruiu Laura Saderi Giovanni Sotgiu Stefania Bassu Marco Zaffanello Roberto Antonucci |
| author_sort | Cristian Locci |
| collection | DOAJ |
| description | The prevalence of hypovitaminosis D is increasing worldwide. Vitamin D deficiency is supposed to play a role in sleep disturbances, but the complex relationships between hypovitaminosis D and pediatric obstructive sleep apnea syndrome (OSAS) are still incompletely understood. This study was aimed to retrospectively investigate the vitamin D status and significant clinical, laboratory, and instrumental variables in a cohort of pediatric patients with OSAS and to assess the possible relationship between serum vitamin D levels and OSAS severity. We consecutively enrolled all children aged 2–14 years admitted to our Pediatric Clinic from 1 July 2018 to 30 November 2020 for sleep-disordered breathing. Each patient underwent standard overnight in-hospital polygraphic evaluation, measurement of serum 25-hydroxyvitamin D (25(OH)D) levels, and clinical and laboratory investigation. A total of 127 children with OSAS were included. The 25(OH)D levels and BMI of OSAS patients were compared with those of an age-matched control group: the serum 25(OH)D levels were significantly lower in OSAS patients than in controls (22.4 vs. 25.5 ng/mL; <i>p</i>-value = 0.009), whereas no differences in the BMI percentile were found between the two groups. The mean value of 25(OH)D was not significantly lower (20.9 ng/mL) in the severe OSAS group compared with the mild (23.0 ng/mL) and moderate (23.3 ng/mL) OSAS groups (<i>p</i>-value = 0.28). Our findings indicate a relationship between vitamin D status and OSAS in children and suggest that severe cases of OSAS have lower vitamin D levels. Future, more extensive prospective studies are needed to confirm such preliminary findings. |
| first_indexed | 2024-03-11T09:36:21Z |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T09:36:21Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-428c39b4646e4b93bca8c4fe1216c1d22023-11-16T17:13:48ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01123124210.3390/jcm12031242Relationships between 25-Hydroxyvitamin D Levels and Obstructive Sleep Apnea Severity in Children: An Observational StudyCristian Locci0Antonella Ruiu1Laura Saderi2Giovanni Sotgiu3Stefania Bassu4Marco Zaffanello5Roberto Antonucci6Pediatric Clinic, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, ItalyPediatric Clinic, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, ItalyClinical Epidemiology and Medical Statistics Unit, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, ItalyClinical Epidemiology and Medical Statistics Unit, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, ItalyDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43, 07100 Sassari, ItalyDepartment of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37129 Verona, ItalyPediatric Clinic, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, ItalyThe prevalence of hypovitaminosis D is increasing worldwide. Vitamin D deficiency is supposed to play a role in sleep disturbances, but the complex relationships between hypovitaminosis D and pediatric obstructive sleep apnea syndrome (OSAS) are still incompletely understood. This study was aimed to retrospectively investigate the vitamin D status and significant clinical, laboratory, and instrumental variables in a cohort of pediatric patients with OSAS and to assess the possible relationship between serum vitamin D levels and OSAS severity. We consecutively enrolled all children aged 2–14 years admitted to our Pediatric Clinic from 1 July 2018 to 30 November 2020 for sleep-disordered breathing. Each patient underwent standard overnight in-hospital polygraphic evaluation, measurement of serum 25-hydroxyvitamin D (25(OH)D) levels, and clinical and laboratory investigation. A total of 127 children with OSAS were included. The 25(OH)D levels and BMI of OSAS patients were compared with those of an age-matched control group: the serum 25(OH)D levels were significantly lower in OSAS patients than in controls (22.4 vs. 25.5 ng/mL; <i>p</i>-value = 0.009), whereas no differences in the BMI percentile were found between the two groups. The mean value of 25(OH)D was not significantly lower (20.9 ng/mL) in the severe OSAS group compared with the mild (23.0 ng/mL) and moderate (23.3 ng/mL) OSAS groups (<i>p</i>-value = 0.28). Our findings indicate a relationship between vitamin D status and OSAS in children and suggest that severe cases of OSAS have lower vitamin D levels. Future, more extensive prospective studies are needed to confirm such preliminary findings.https://www.mdpi.com/2077-0383/12/3/1242vitamin Dhypovitaminosis Dobstructive sleep apnea syndromechildren |
| spellingShingle | Cristian Locci Antonella Ruiu Laura Saderi Giovanni Sotgiu Stefania Bassu Marco Zaffanello Roberto Antonucci Relationships between 25-Hydroxyvitamin D Levels and Obstructive Sleep Apnea Severity in Children: An Observational Study Journal of Clinical Medicine vitamin D hypovitaminosis D obstructive sleep apnea syndrome children |
| title | Relationships between 25-Hydroxyvitamin D Levels and Obstructive Sleep Apnea Severity in Children: An Observational Study |
| title_full | Relationships between 25-Hydroxyvitamin D Levels and Obstructive Sleep Apnea Severity in Children: An Observational Study |
| title_fullStr | Relationships between 25-Hydroxyvitamin D Levels and Obstructive Sleep Apnea Severity in Children: An Observational Study |
| title_full_unstemmed | Relationships between 25-Hydroxyvitamin D Levels and Obstructive Sleep Apnea Severity in Children: An Observational Study |
| title_short | Relationships between 25-Hydroxyvitamin D Levels and Obstructive Sleep Apnea Severity in Children: An Observational Study |
| title_sort | relationships between 25 hydroxyvitamin d levels and obstructive sleep apnea severity in children an observational study |
| topic | vitamin D hypovitaminosis D obstructive sleep apnea syndrome children |
| url | https://www.mdpi.com/2077-0383/12/3/1242 |
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