Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering
Hydroxyapatite (HA) exhibits several desirable characteristics, but it still lacks osteoinduction, which is a necessary requirement for a bone scaffold. HA-based composites with different amounts of Bioglass® (BG) were prepared using spark plasma sintering (SPS). Careful selection of the SPS paramet...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Novi Sad
2021-09-01
|
| Series: | Processing and Application of Ceramics |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/1820-6131/2021/1820-61312103270R.pdf |
| _version_ | 1818719255558881280 |
|---|---|
| author | Rizwan Muhammad Chandio Ali Dad Sohail Muhammad Bashir Nasir M. Yousuf Sumra Alias Rodianah Rehman Hammad ur Hamdi M. Basirun Jeffrey Wan |
| author_facet | Rizwan Muhammad Chandio Ali Dad Sohail Muhammad Bashir Nasir M. Yousuf Sumra Alias Rodianah Rehman Hammad ur Hamdi M. Basirun Jeffrey Wan |
| author_sort | Rizwan Muhammad |
| collection | DOAJ |
| description | Hydroxyapatite (HA) exhibits several desirable characteristics, but it still lacks osteoinduction, which is a necessary requirement for a bone scaffold. HA-based composites with different amounts of Bioglass® (BG) were prepared using spark plasma sintering (SPS). Careful selection of the SPS parameters avoided undesirable reactions between the calcium phosphate (CaP) and bioglass (BG present in the form of powder and fibres), as confirmed through X-ray diffraction analysis. Scanning electron microscopy images of the composite scaffolds revealed a fibre like appearance of the glassy region. The in vitro bioactivity and biodegradation analyses were performed by immersing the composites in simulated body fluid (SBF) and tris(hydroxymethyl)aminomethane (Tris), respectively. The ability to obtain only the CaP phase and glassy phase with desirable bioactive and biodegradation behaviour, indicated that these SPS scaffolds can be employed as bone scaffolds for clinical trials, after further in vivo analyses. |
| first_indexed | 2024-12-17T20:04:02Z |
| format | Article |
| id | doaj.art-428c8393027142719c3de587e10d769f |
| institution | Directory Open Access Journal |
| issn | 1820-6131 2406-1034 |
| language | English |
| last_indexed | 2024-12-17T20:04:02Z |
| publishDate | 2021-09-01 |
| publisher | University of Novi Sad |
| record_format | Article |
| series | Processing and Application of Ceramics |
| spelling | doaj.art-428c8393027142719c3de587e10d769f2022-12-21T21:34:23ZengUniversity of Novi SadProcessing and Application of Ceramics1820-61312406-10342021-09-01153270278https://doi.org/10.2298/PAC2103270RBioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineeringRizwan Muhammad0Chandio Ali Dad1Sohail Muhammad2Bashir Nasir M.3Yousuf Sumra4Alias Rodianah5Rehman Hammad ur6Hamdi M.7Basirun Jeffrey Wan8Department of Metallurgical Engineering, Faculty of Chemical and Process Engineering, NED University of Engineering and Technology, Karachi, Pakistan + Department of Mechanical Engineering, University of Malaya, Kuala Lumpur, MalaysiaDepartment of Metallurgical Engineering, Faculty of Chemical and Process Engineering, NED University of Engineering and Technology, Karachi, PakistanDepartment of Materials Engineering, Faculty of Chemical and Process Engineering, NED University of Engineering and Technology, Karachi, PakistanNational University of Sciences and Technology Islamabad, PakistanDepartment of Building and Architectural Engineering, Faculty of Engineering & Technology, Bahauddin Zakariya University, Multan, Pakistan + Department of Civil Engineering, University of Malaya, Kuala Lumpur, MalaysiaDepartment of Mechanical Engineering, University of Malaya, Kuala Lumpur, Malaysia + Faculty of Innovative Design & Technology, University Sultan Zainal Abidin, Kuala Terengganu, MalaysiaDepartment of Metallurgical Engineering, Faculty of Chemical and Process Engineering, NED University of Engineering and Technology, Karachi, PakistanChancellery office, University of Malaya, Kuala Lumpur, MalaysiaDepartment of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, MalaysiaHydroxyapatite (HA) exhibits several desirable characteristics, but it still lacks osteoinduction, which is a necessary requirement for a bone scaffold. HA-based composites with different amounts of Bioglass® (BG) were prepared using spark plasma sintering (SPS). Careful selection of the SPS parameters avoided undesirable reactions between the calcium phosphate (CaP) and bioglass (BG present in the form of powder and fibres), as confirmed through X-ray diffraction analysis. Scanning electron microscopy images of the composite scaffolds revealed a fibre like appearance of the glassy region. The in vitro bioactivity and biodegradation analyses were performed by immersing the composites in simulated body fluid (SBF) and tris(hydroxymethyl)aminomethane (Tris), respectively. The ability to obtain only the CaP phase and glassy phase with desirable bioactive and biodegradation behaviour, indicated that these SPS scaffolds can be employed as bone scaffolds for clinical trials, after further in vivo analyses.http://www.doiserbia.nb.rs/img/doi/1820-6131/2021/1820-61312103270R.pdfhydroxyapatitebioglass®spark plasma sinteringbioactivitybiodegradation |
| spellingShingle | Rizwan Muhammad Chandio Ali Dad Sohail Muhammad Bashir Nasir M. Yousuf Sumra Alias Rodianah Rehman Hammad ur Hamdi M. Basirun Jeffrey Wan Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering Processing and Application of Ceramics hydroxyapatite bioglass® spark plasma sintering bioactivity biodegradation |
| title | Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering |
| title_full | Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering |
| title_fullStr | Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering |
| title_full_unstemmed | Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering |
| title_short | Bioglass-fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering |
| title_sort | bioglass fibre reinforced hydroxyapatite composites synthesized using spark plasma sintering for bone tissue engineering |
| topic | hydroxyapatite bioglass® spark plasma sintering bioactivity biodegradation |
| url | http://www.doiserbia.nb.rs/img/doi/1820-6131/2021/1820-61312103270R.pdf |
| work_keys_str_mv | AT rizwanmuhammad bioglassfibrereinforcedhydroxyapatitecompositessynthesizedusingsparkplasmasinteringforbonetissueengineering AT chandioalidad bioglassfibrereinforcedhydroxyapatitecompositessynthesizedusingsparkplasmasinteringforbonetissueengineering AT sohailmuhammad bioglassfibrereinforcedhydroxyapatitecompositessynthesizedusingsparkplasmasinteringforbonetissueengineering AT bashirnasirm bioglassfibrereinforcedhydroxyapatitecompositessynthesizedusingsparkplasmasinteringforbonetissueengineering AT yousufsumra bioglassfibrereinforcedhydroxyapatitecompositessynthesizedusingsparkplasmasinteringforbonetissueengineering AT aliasrodianah bioglassfibrereinforcedhydroxyapatitecompositessynthesizedusingsparkplasmasinteringforbonetissueengineering AT rehmanhammadur bioglassfibrereinforcedhydroxyapatitecompositessynthesizedusingsparkplasmasinteringforbonetissueengineering AT hamdim bioglassfibrereinforcedhydroxyapatitecompositessynthesizedusingsparkplasmasinteringforbonetissueengineering AT basirunjeffreywan bioglassfibrereinforcedhydroxyapatitecompositessynthesizedusingsparkplasmasinteringforbonetissueengineering |