A Simple-to-Perform ifn-γ mRNA Gene Expression Assay on Whole Blood Accurately Appraises Varicella Zoster Virus-Specific Cell-Mediated Immunity After Allogeneic Hematopoietic Stem Cell Transplantation

A Simple-to-Perform ifn-γ mRNA Gene Expression Assay on Whole Blood Accurately Appraises Varicella Zoster Virus-Specific Cell-Mediated Immunity After Allogeneic Hematopoietic Stem Cell Transplantation

Herpes zoster, which is due to the reactivation of Varicella zoster virus (VZV), is a leading cause of morbidity after allogeneic hematopoietic stem cell transplantation (allo-HSCT). While cell-mediated immunity (CMI) is critical to inhibiting VZV reactivation, CMI is not routinely assessed due to a...

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Bibliographic Details
Main Authors: Mathilde Boccard, Anne Conrad, William Mouton, Florent Valour, Chantal Roure-Sobas, Emilie Frobert, Barbara Rohmer, Vincent Alcazer, Hélène Labussière-Wallet, Hervé Ghesquières, Fabienne Venet, Karen Brengel-Pesce, Sophie Trouillet-Assant, Florence Ader
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
varicella zoster virus
hematopoietic stem cell transplantation
cell-mediated immunity
immune functional assays
interferon gamma
antiviral prophylaxis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.919806/full

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