Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)
According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managin...
| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Médium: | Článek |
| Jazyk: | English |
| Vydáno: |
Elsevier
2020-10-01
|
| Edice: | World Allergy Organization Journal |
| Témata: | |
| On-line přístup: | http://www.sciencedirect.com/science/article/pii/S1939455120303677 |
| _version_ | 1828838991466594304 |
|---|---|
| author | Giorgio Walter Canonica Francesco Blasi Pierluigi Paggiaro Gianenrico Senna Giovanni Passalacqua Antonio Spanevello Stefano Aliberti Diego Bagnasco Marco Bonavia Matteo Bonini Luisa Brussino Caterina Bucca Maria F. Caiaffa Cecilia Calabrese Gianna Camiciottoli Marco Caminati Giovanna E. Carpagnano Cristiano Caruso Stefano Centanni Maria E. Conte Angelo G. Corsico Lorenzo Cosmi Maria T. Costantino Nunzio Crimi Simona D’Alò Maria D'Amato Stefano Del Giacco Alessandro Farsi Elisabetta Favero Maria P. Foschino Barbaro Gabriella Guarnieri Giuseppe Guida Manuela Latorre Salvatore Lo Cicero Carlo Lombardi Luigi Macchia Francesco Mazza Francesco Menzella Manlio Milanese Marcello Montagni Paolo Montuschi Eleonora Nucera Roberta Parente Vincenzo Patella Girolamo Pelaia Laura Pini Francesca Puggioni Luisa Ricciardi Fabio L.M. Ricciardolo Luca Richeldi Erminia Ridolo Giovanni Rolla Pierachille Santus Nicola Scichilone Giuseppe Spadaro Andrea Vianello Vittorio Viviano Mona R. Yacoub Maria C. Zappa Enrico Heffler |
| author_facet | Giorgio Walter Canonica Francesco Blasi Pierluigi Paggiaro Gianenrico Senna Giovanni Passalacqua Antonio Spanevello Stefano Aliberti Diego Bagnasco Marco Bonavia Matteo Bonini Luisa Brussino Caterina Bucca Maria F. Caiaffa Cecilia Calabrese Gianna Camiciottoli Marco Caminati Giovanna E. Carpagnano Cristiano Caruso Stefano Centanni Maria E. Conte Angelo G. Corsico Lorenzo Cosmi Maria T. Costantino Nunzio Crimi Simona D’Alò Maria D'Amato Stefano Del Giacco Alessandro Farsi Elisabetta Favero Maria P. Foschino Barbaro Gabriella Guarnieri Giuseppe Guida Manuela Latorre Salvatore Lo Cicero Carlo Lombardi Luigi Macchia Francesco Mazza Francesco Menzella Manlio Milanese Marcello Montagni Paolo Montuschi Eleonora Nucera Roberta Parente Vincenzo Patella Girolamo Pelaia Laura Pini Francesca Puggioni Luisa Ricciardi Fabio L.M. Ricciardolo Luca Richeldi Erminia Ridolo Giovanni Rolla Pierachille Santus Nicola Scichilone Giuseppe Spadaro Andrea Vianello Vittorio Viviano Mona R. Yacoub Maria C. Zappa Enrico Heffler |
| author_sort | Giorgio Walter Canonica |
| collection | DOAJ |
| description | According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. New biologics have clearly demonstrated that this effect is possible, with concomitant reduction in the rate of exacerbations and in symptom control. Then, there is no reason for using so frequently oral corticosteroid before having explored all alternatives currently available for a large part of severe asthmatics. |
| first_indexed | 2024-12-12T19:14:08Z |
| format | Article |
| id | doaj.art-428dc045dcb24b51a1fbbdb015fa1cb4 |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-12-12T19:14:08Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-428dc045dcb24b51a1fbbdb015fa1cb42022-12-22T00:14:46ZengElsevierWorld Allergy Organization Journal1939-45512020-10-011310100464Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)Giorgio Walter Canonica0Francesco Blasi1Pierluigi Paggiaro2Gianenrico Senna3Giovanni Passalacqua4Antonio Spanevello5Stefano Aliberti6Diego Bagnasco7Marco Bonavia8Matteo Bonini9Luisa Brussino10Caterina Bucca11Maria F. Caiaffa12Cecilia Calabrese13Gianna Camiciottoli14Marco Caminati15Giovanna E. Carpagnano16Cristiano Caruso17Stefano Centanni18Maria E. Conte19Angelo G. Corsico20Lorenzo Cosmi21Maria T. Costantino22Nunzio Crimi23Simona D’Alò24Maria D'Amato25Stefano Del Giacco26Alessandro Farsi27Elisabetta Favero28Maria P. Foschino Barbaro29Gabriella Guarnieri30Giuseppe Guida31Manuela Latorre32Salvatore Lo Cicero33Carlo Lombardi34Luigi Macchia35Francesco Mazza36Francesco Menzella37Manlio Milanese38Marcello Montagni39Paolo Montuschi40Eleonora Nucera41Roberta Parente42Vincenzo Patella43Girolamo Pelaia44Laura Pini45Francesca Puggioni46Luisa Ricciardi47Fabio L.M. Ricciardolo48Luca Richeldi49Erminia Ridolo50Giovanni Rolla51Pierachille Santus52Nicola Scichilone53Giuseppe Spadaro54Andrea Vianello55Vittorio Viviano56Mona R. Yacoub57Maria C. Zappa58Enrico Heffler59Personalized Medicine, Asthma & Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, MI, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), ItalyRespiratory Unit and Adult Cystic Fibrosis Center, And Department of Pathophysiology and Transplantation, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, University of Milan, ItalyDepartment of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, ItalyDepartment of Medicine, Allergy Unit Asthma Center, University of Verona, ItalyAllergy and Respiratory Diseases, IRCCS Policlinico San Martino, University of Genoa, ItalyUniversity of Insubria, ICS Maugeri, IRCCS, Varese, ItalyRespiratory Unit and Adult Cystic Fibrosis Center, And Department of Pathophysiology and Transplantation, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, University of Milan, ItalyAllergy and Respiratory Diseases, IRCCS Policlinico San Martino, University of Genoa, ItalyRespiratory Rehabilitation, ASL3, Genoa, ItalyFondazione Policlinico Universitario A. Gemelli, IRCCS Catholic University of Rome, ItalyAllergy and Clinical Immunology, University of Turin & AO Mauriziano, Turin, Italy; Respiratory Medicine, Department of Medical Sciences, University of Turin, ItalyAllergy and Clinical Immunology, University of Turin & AO Mauriziano, Turin, Italy; Respiratory Medicine, Department of Medical Sciences, University of Turin, ItalyDepartment of Medical Sciences and Surgery, School and Chair of Allergology and Clinical Immunology, University of Foggia, ItalyDepartment of Translational Medical Sciences, University of Campania “L. Vanvitelli”, Naples, ItalyDeptartment of Experimental and Clinical Biomedical Sciences “Mario Serio”, Respiratory Unit, Careggi University Hospital, Florence, ItalyDepartment of Medicine, Allergy Unit Asthma Center, University of Verona, ItalyRespiratory Medicine Section, Policlinico of Bari, Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, ItalyAllergy Unit, Fondazione Policlinico A. Gemelli, IRCCS, Rome, ItalyDepartment of Health Sciences, University of Milan, Respiratory Unit, ASST Santi Paolo e Carlo, Milan, ItalyRespiratory Unit, Presidio Ospedaliero of Pordenone, ItalyDivision of Respiratory Diseases, IRCCS Policlinico San Matteo, Foundation and Department of Internal Medicine and Therapeutics, University of Pavia, ItalyDepartment of Experimental and Clinical Medicine, University of Florence, Florence, ItalyAllergy and Clinical Immunology Unit, Department of Medicine, “Carlo Poma” Hospital, Mantova, ItalyDivision of Pneumology and Allergology, Policlinico, University of Catania, ItalyAllergology Unit, AV3 ASUR Marche, Hospital Civitanova Marche, Macerata, ItalyRespiratory Department, Division of Respiratory Diseases “Federico II” University, AO Dei Colli, Naples, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, ItalySOS of Allergology and Clinical Immunology, Azienda USL Toscana Centro, Prato, ItalySevere Asthma Multidisciplinary Outpatient Clinic, Vittorio Veneto Hospital, Treviso, ItalySection of Respiratory Diseases, Medical and Surgical Sciences Department, University of Foggia, ItalyDepartment of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padua, ItalyAllergy and Pneumology Unit, A.O. S. Croce & Carle, Cuneo, ItalyDepartment of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, ItalyDepartment of Pneumology, Niguarda Hospital, Milan, ItalyDepartmental Unit of Allergology and Pneumology, Hospital Institute Fondazione Poliambulanza, Brescia, ItalyDepartment of Emergency and Organ Transplantation, School and Chair of Allergology and Clinical Immunology, University of Bari Aldo Moro, Bari, ItalyRespiratory Unit, Presidio Ospedaliero of Pordenone, ItalyPneumology Unit, Santa Maria Nuova Hospital, Azienda USL di Reggio Emilia IRCCS, ItalyPulmonology Unit, ASL2 Savonese, Pietra Ligure, Savona, ItalyUOC Allergology Department, Piacenza, ItalyDepartment of Pharmacology, Faculty of Medicine Catholic, University of the Sacred Heart Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyCatholic University S. Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDepartment of Medicine, Division of Allergy and Clinical Immunology, University of Salerno, ItalyAllergology and Clinical Immunology Unit, Department of Medical Science, “Santa Maria Della Speranza” Hospital of Battipaglia, Salerno, ItalyDepartment of Medical and Surgical Sciences, Section of Respiratory Diseases, University Magna Graecia, Catanzaro, ItalyDepartment of Clinical and Experimental Sciences, University of Brescia, Spedali Civili, Brescia, ItalyPersonalized Medicine, Asthma & Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, MI, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), ItalyAllergy and Clinical Immunology Unit, University Hospital “G. Martino”, Department of Clinical and Experimental Medicine, University of Messina, ItalyDepartment of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Turin, ItalyFondazione Policlinico Universitario A. Gemelli, IRCCS Catholic University of Rome, ItalyDepartment of Medicine and Surgery, University of Parma, ItalyAllergy and Clinical Immunology, University of Turin & AO Mauriziano, Turin, Italy; Respiratory Medicine, Department of Medical Sciences, University of Turin, ItalyDepartment of Clinical and Biomedical Sciences, University of Milan, Respiratory Diseases, Sacco University Hospital, ASST Fatebenefratelli-Sacco, Milan, ItalyDivision of Respiratory Diseases, Department of Promoting Health, Maternal-Infant. Excellence and Internal and Specialized Medicine (Promise) G. D'Alessandro, University of Palermo, Palermo, ItalyDepartment of Internal Medicine, Clinical Immunology, Clinical Pathology and Infectious Diseases, Azienda Ospedaliera Universitaria Federico II, Naples, ItalyDivision of Respiratory Pathophysiology, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, ItalyAllergology, Pneumology and Respiratory Department 42 PTA Biondo-Regional Center for Allergy Prevention and Anaphylactic Shock, Palermo, ItalyUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Milan, ItalyPulmonology Department, Sandro Pertini Hospital, Rome, ItalyPersonalized Medicine, Asthma & Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, MI, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele (MI), Italy; Corresponding author. Personalized Medicine, Asthma and Allergy, Istituto Clinico Humanitas, Via Alessandro Manzoni 56, 20089, Rozzano, (MI), Italy.According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. New biologics have clearly demonstrated that this effect is possible, with concomitant reduction in the rate of exacerbations and in symptom control. Then, there is no reason for using so frequently oral corticosteroid before having explored all alternatives currently available for a large part of severe asthmatics.http://www.sciencedirect.com/science/article/pii/S1939455120303677Severe asthmaBiologicsOral corticosteroidsReal-lifeRegistr |
| spellingShingle | Giorgio Walter Canonica Francesco Blasi Pierluigi Paggiaro Gianenrico Senna Giovanni Passalacqua Antonio Spanevello Stefano Aliberti Diego Bagnasco Marco Bonavia Matteo Bonini Luisa Brussino Caterina Bucca Maria F. Caiaffa Cecilia Calabrese Gianna Camiciottoli Marco Caminati Giovanna E. Carpagnano Cristiano Caruso Stefano Centanni Maria E. Conte Angelo G. Corsico Lorenzo Cosmi Maria T. Costantino Nunzio Crimi Simona D’Alò Maria D'Amato Stefano Del Giacco Alessandro Farsi Elisabetta Favero Maria P. Foschino Barbaro Gabriella Guarnieri Giuseppe Guida Manuela Latorre Salvatore Lo Cicero Carlo Lombardi Luigi Macchia Francesco Mazza Francesco Menzella Manlio Milanese Marcello Montagni Paolo Montuschi Eleonora Nucera Roberta Parente Vincenzo Patella Girolamo Pelaia Laura Pini Francesca Puggioni Luisa Ricciardi Fabio L.M. Ricciardolo Luca Richeldi Erminia Ridolo Giovanni Rolla Pierachille Santus Nicola Scichilone Giuseppe Spadaro Andrea Vianello Vittorio Viviano Mona R. Yacoub Maria C. Zappa Enrico Heffler Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI) World Allergy Organization Journal Severe asthma Biologics Oral corticosteroids Real-life Registr |
| title | Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI) |
| title_full | Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI) |
| title_fullStr | Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI) |
| title_full_unstemmed | Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI) |
| title_short | Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI) |
| title_sort | oral corticosteroid sparing with biologics in severe asthma a remark of the severe asthma network in italy sani |
| topic | Severe asthma Biologics Oral corticosteroids Real-life Registr |
| url | http://www.sciencedirect.com/science/article/pii/S1939455120303677 |
| work_keys_str_mv | AT giorgiowaltercanonica oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT francescoblasi oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT pierluigipaggiaro oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT gianenricosenna oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT giovannipassalacqua oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT antoniospanevello oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT stefanoaliberti oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT diegobagnasco oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT marcobonavia oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT matteobonini oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT luisabrussino oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT caterinabucca oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT mariafcaiaffa oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT ceciliacalabrese oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT giannacamiciottoli oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT marcocaminati oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT giovannaecarpagnano oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT cristianocaruso oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT stefanocentanni oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT mariaeconte oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT angelogcorsico oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT lorenzocosmi oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT mariatcostantino oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT nunziocrimi oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT simonadalo oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT mariadamato oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT stefanodelgiacco oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT alessandrofarsi oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT elisabettafavero oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT mariapfoschinobarbaro oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT gabriellaguarnieri oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT giuseppeguida oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT manuelalatorre oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT salvatorelocicero oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT carlolombardi oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT luigimacchia oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT francescomazza oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT francescomenzella oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT manliomilanese oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT marcellomontagni oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT paolomontuschi oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT eleonoranucera oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT robertaparente oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT vincenzopatella oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT girolamopelaia oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT laurapini oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT francescapuggioni oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT luisaricciardi oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT fabiolmricciardolo oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT lucaricheldi oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT erminiaridolo oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT giovannirolla oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT pierachillesantus oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT nicolascichilone oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT giuseppespadaro oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT andreavianello oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT vittorioviviano oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT monaryacoub oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT mariaczappa oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani AT enricoheffler oralcorticosteroidsparingwithbiologicsinsevereasthmaaremarkofthesevereasthmanetworkinitalysani |